Systematic summarization of the expression profiles and prognostic roles of the dishevelled gene family in hepatocellular carcinoma

Abstract

Background Dishevelled (DVL) family members are crucial to Wnt‐induced signaling transduction, and their expression is highly correlated with the progression of multiple malignant cancers. However, the expression profiles and exact prognostic values of DVLs in hepatocellular carcinoma (HCC) have not been explored until now. Methods The expression of DVL isoforms was assessed using the Oncomine, HCCDB and UALCAN databases. The prognostic roles of DVLs were further evaluated using the GEPIA database. The relationship between the expression of DVLs and immune infiltration of HCC was investigated using the Timer and ImmuCellAI tools. Furthermore, protein–protein interaction (PPI) networks were built and enrichment analyses were conducted. Results We found that the expression levels of DVL2 (OMIM accession number: 602151) and DVL3 (OMIM accession number: 601368) were upregulated in HCC tissues as revealed by the Oncomine and HCCDB databases. Additionally, the expression of DVLs tended to be associated with advanced clinical features in the UALCAN database. Prognostic analysis revealed that the expression levels of DVL1 (OMIM accession number: 601365) and DVL3 were remarkably associated with a poor prognosis in HCC patients. The results also revealed that the DVL expression level was correlated with the infiltration levels of multiple immune cells. By constructing the PPI network and enrichment analyses, the DVL1‐3 gene was identified to interact with 20 key genes and participate in several pathways. Conclusion In summary, DVL2 and DVL3 are highly expressed in HCC, and DVL1 and DVL3 are related to a poor prognosis, which might be used as candidate targets for targeted therapy and reliable prognostic biomarkers in HCC.

Patterns of Immune Infiltration and the Key Immune-Related Genes in Acute Type A Aortic Dissection in Bioinformatics Analyses

“…ImmuCellAI ( http://bioinfo.life.hust.edu.cn/web/ImmuCellAI/ ) 7 algorithm was used to estimate the abundance of 24 types of immune cells based on a gene expression data set. 14 Eighteen T-cell subsets and six key immune cells including natural killer cells (NK cells), dendritic cells (DCs), neutrophils, monocytes, macrophages and B cells.…”

Spaceflight alters host-gut microbiota interactions

“…So-called non-tight junction claudins have only recently been experimentally explored and, in hepatic cells, CLDN1 is implicated in hepatocellular carcinoma (HCC) 144 . More broadly, significant upregulation of Tgf-α and genes involved in complex Tgf-β signalling ( Tgfb2 , Tgfb3 , Tab2 , Tgfbrap , Smad3 ), alongside other markers ( Dapk2 , Vegfa , Dvl3 ) 145,146 are associated to HCC, as well as immune suppression through the cyclin-dependent kinase inhibitor 1A ( p21 cip 1 ; Cdkn1a ) 147 , also significantly upregulated after 29 and 56 days of spaceflight. Previous gene expression analysis of mice exposed to high-energy ion particle radiation to simulate exposure to Galactic Cosmic Rays reported induction of spontaneous HCC 146 .…”

Antitumor Effect of Pseudolaric Acid B Involving Regulation of Notch1/Akt Signaling Response in Human Hepatoma Cell In Vitro

“…As reported, the expected 5-year survival rate of advanced HCC patients is 5%–15%. Although sorafenib has been approved for clinical treatment, the severe side effects impede its long-term use [ 37 , 38 ]. Moreover, sorafenib resistance is emerging clinically, and meanwhile, it has been evidenced that the disruption of Notch/Akt signaling could drive malignant behaviors and drug resistance in many cancers [ 39 , 40 ].…”