Systematic Utilization of an Antipseudomonas Aeruginosa Vaccine in A Severe Burn Unit

Protective Mechanisms of Experimental Vaccine-Induced Immunity to <i>Pseudomonas aeruginos</i><i>a</i>

“…all experimen tal vaccines are claimed to be nontoxic or 'well tolerated', even heat-killed whole cells [55], However, it is likely that most prepara tions of cell surface antigens would contain some LPS. Thus, the degree of toxicity would probably be related to the amount of LPS present in the vaccine or, stated in other terms, the least toxic vaccines would likely be the most highly purified (non-LPS) vaccines.…”

“…Ribosomal vaccines against P. aeruginosa have been shown to provide effective immu nity to host animals [41][42][43][44][45], While the iden tity of the effective immunogen is still in question, the safety and efficacy of ribosomal vaccines against several other pathogenic or ganisms have been documented in humans [46,47] as well as laboratory animals [48,49], Finally, a variety of other materials has been tested as potential Pseudomonas vac cines, including a 'slime' glycolipoprotein [50], a 'slime' PS protein mixture [51], a glycine-EDTA cell wall extract [52], aqueous cellular protein extracts [53,54], as well as whole cell vaccines cither heat-killed [55], or attenuated by a temperature-sensitive muta tion [56], The vaccines discussed above and appropriate references are listed in table I.…”