The paper attempts to deal with professional self-determination of young people through an acmeological approach. Acmeology is a science that studies patterns and features of human development at the stage of maturity, as well as ways and means of reaching the pinnacle in this development. Since A.A. Derkach defines acmeological approach as a process of formation and consolidation of a real need for selfknowledge, self-development and self-realization in the human consciousness, it is quite possible to consider professional self-determination from an acmeological standpoint. The paper analyzes objective and subjective impacts that hinder a person to reach the "acme" and compares them with the process of achieving professional self-determination. The paper provides a novel rationale to the possibility of extrapolating the acmeological approach, its basic concepts and provisions to the process of professional self-determination. The authors show that considering professional self-determination in the context of life track, life philosophy, life script, life-purpose values and professional "acme" enables a holistic approach to be applied in a single set of all interdependent impacts and links. The authors describe continuous, discrete, divergent and ascending tracks of professional self-determination, correlate acmeological invariants of professionalism with soft and general professional competencies necessary for a professional to succeed in the digital economy. The results of sociological research conducted by the authors confirm the stated theoretical propositions.