Systemic lupus erythematosus in dogs: Association to the major histocompatibility complex class I antigen DLA-A7

Subgroups of canine antinuclear antibodies in relation to laboratory and clinical findings in immune‐mediated disease

“…This may indicate a breed‐specific disorder with common autoantigenic reactivity, and could reflect a hereditary susceptibility among German Shepherds to a certain subtype of systemic autoimmune disease. In an earlier study, an association was found between expression of a particular leukocyte antigen and autoimmune systemic disease in this breed 34. This finding is in concordance with observations in humans, in whom autoimmune diseases often are associated with certain types of human leukocyte antigens 35,36.…”

A review of immunologic diseases of the dog

“…Humans with SLE are more likely to have the HLA-DR2 or -DR3 leukocyte types than non-affected individuals. DLA-A7 was found to have a strong positive relationship to SLE in German shepherd dogs, while DLA-A1 and DLA-B5 were negatively related (Teichner et al, 1990).…”

Construction and Characterization of an Eightfold Redundant Dog Genomic Bacterial Artificial Chromosome Library

“…The compartmentalization of the species into breeds, together with the relatively short generation time of the dog (2-3 years), offers the potential of cloning genes not only using linkage analysis but also using identity by descent studies in sporadic cases. Disorders as diverse as narcolepsy (Mignot et al, 1991;Kadotani et al, 1998), Duchenne muscular dystrophy (Cooper et al, 1988), von Willebrand disease (Thomas, 1996), lupus erythematosus (Teichner et al, 1990), immunodeficiencies Ameratunga et al, 1998), retinal degeneration (Acland et al, 1998), Xlinked nephritis (Zheng et al, 1994), congenital heart disease (Patterson et al, 1993), and various metabolic disorders Skelly et al, 1996;Victoria et al, 1996;Kishnani et al, 1997;Ray et al, 1998) have been reported to segregate in dog pedigrees. In several cases, candidate gene approaches have led to the isolation of genes homologous to those observed in the corresponding human disorders (Cooper et al, 1988;Henthorn et al, 1994;Zheng et al, 1994;Smith et al, 1996;Skelly et al, 1996;Thomas, 1996;Victoria et al, 1996;Kishnani et al, 1997;Ameratunga et al, 1998;Ray et al, 1998).…”