Systemic lupus erythematosus in three ethnic groups. VI: Factors associated                 with fatigue within 5 years of criteria diagnosis

Zonana-Nacach, Abraham; Roseman, Jeffrey M.; McGwin, Gerald; Friedman, Alan Warren; Baethge, Bruce A.; Reveille, John D.

doi:10.1191/096120300678828046

Cited by 125 publications

(159 citation statements)

References 32 publications

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“…The Fatigue Severity Scale has been used to subjectively evaluate fatigue in SLE and other chronic conditions (1,4,19,20). Previous studies reported FSS in patients with SLE ranging from 4.6 to 5.3 (1,19). These scores were similar to the scores of patients with mild SLE in the current study.…”

Section: Discussionmentioning

confidence: 99%

Evidence for aerobic insufficiency in women with systemic lupus erythematosus

Keyser¹,

Rus²,

Cade³

et al. 2003

Arthritis & Rheumatism

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Objective. To determine if fatigue is associated with diminished aerobic capacity in women with systemic lupus erythematosus (SLE). Methods. Eighteen women (age 35 ؎ 9 years) with mild SLE (Systemic Lupus Activity Measure ‫؍‬ 3.1 ؎ 2.1) and 16 healthy but sedentary controls (age 38 ؎ 8 years) completed peak treadmill exercise tests to determine aerobic capacity and Fatigue Severity Scales to quantify the severity of fatigue. Measures of oxygen consumption (VO 2 ) were recorded during the treadmill tests. Results. Peak VO 2 was lower in patients with SLE (19.2 ؎ 4.4 ml/kg/minute) as compared with controls (27.4 ؎ 4.7 ml/kg/minute) and expected values (30.7 ؎ 3.1 ml/kg/minute; P < 0.0006 versus controls and P < 0.0001 versus expected). Functional aerobic impairment was observed in 14 of the 18 patients with SLE. In patients with SLE, ventilatory threshold, a marker for the onset of lactic acidemia, was observed at the lowest energy requirement for instrumental activities of daily living. Peak VO 2 in the patients with SLE was similar to the highest energy requirements for instrumental activities of daily living, leaving little or no reserve for more intense occupational and recreational activities. Peak VO 2 was significantly higher (P < 0.0001) than the activity of daily living requirements in controls, providing a substantial energy reserve. Fatigue severity score (FSS) was 5.0 ؎ 1.4 in patients with SLE, with 14 of the 18 patients having scores above 4.0, a score indicating that fatigue severity limited physical activity. Of the 14, 12 had functional aerobic impairment. An FSS of greater than 4.0 was not observed in controls (mean ‫؍‬ 2.5 ؎ 0.7). Conclusion. In women with SLE, aerobic capacity was diminished to levels that were insufficient for engaging in activities of daily living and below those expected to result from physiologic deconditioning. This functional aerobic impairment was strongly correlated with the perception of severe, activity-limiting fatigue.

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Section: Discussionmentioning

confidence: 99%

Evidence for aerobic insufficiency in women with systemic lupus erythematosus

Keyser¹,

Rus²,

Cade³

et al. 2003

Arthritis & Rheumatism

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“…A detailed description of the LUMINA cohort has been published previously (23)(24)(25)(26)(27)(28). We are therefore describing only the salient baseline features for the LUMINA patients included in these analyses (72 Hispanics, 104 African Americans, and 82 Caucasians).…”

Section: Resultsmentioning

confidence: 99%

“…The constitution of this cohort, the variables obtained prior to, at, and after enrollment in the cohort, and the frequency and nature of the study visits have been described in detail previously (23)(24)(25)(26)(27)(28). Briefly, patients with SLE according to the American College of Rheumatology (ACR) criteria (4,29,30) who had disease duration of Յ5 years at enrollment, were living within the catchment area of the participating institutions (The University of Alabama at Birmingham, The University of Texas-Houston Health Science Center, and The University of Texas Medical Branch at Galveston), and were of defined Hispanic (Mexican American or Central American), African American, or Caucasian ethnicity were eligible to participate.…”

Section: Methodsmentioning

confidence: 99%

“…It is unclear, however, how damage accrues in these population groups compared with the Caucasian population. To sort out the genetic and socioeconomic/demographic factors associated with poor outcome in SLE, a cohort of patients with disease duration of Յ5 years, from the 3 major ethnic groups inhabiting the US (Hispanic, African American, and Caucasian) was constituted and is being followed up longitudinally (23)(24)(25)(26)(27)(28). We are now reporting on the accrual of damage, overall and by ethnic group, in the cohort.…”

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confidence: 99%

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Systemic lupus erythematosus in three ethnic groups: IX. Differences in damage accrual

Alarcón

McGwin

Bartolucci

et al. 2001

Arthritis & Rheumatism

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251

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“…Vários factores são reconhecidos como contribuintes para a fadiga, como a actividade da doença, desordens de humor, padrões de sono inadequados, forma física aeróbica debilitada e presença de fibromialgia (Krupp, 1990;Tench et al, 2000;Wy-senbeek et al, 1993;Zonana-Nacach et al, 2000). A relação entre a fadiga e a actividade da doença é controversa.…”

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Severe Fatigue in Patients With Systemic Lupus Erythematosus: A Study on the Psychometric Properties of the Severity Fatigue Scale

Pereira¹,

Duarte²

2010

Psic., Saúde & Doença

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RESUMO:O principal objectivo deste estudo foi realizar a adaptação da Escala da Intensidade da Fadiga (Krupp et al., 1989), que visa avaliar a percepção do nível de fadiga em doentes com Lúpus Eritematoso Sistémico (LES). Os resultados, numa amostra de 104 doentes com LES, ao nível da análise factorial revelaram que os itens da versão original se organizam exactamente num único factor, de acordo com o modelo original. Em termos de fidelidade, o coeficiente encontrado foi .96 indicando uma elevada consistência interna dos itens tal como verificado na versão original que foi de .88. Deste modo, a Escala da Intensidade da Fadiga apresenta boas qualidades psicométricas para ser utilizada como medida de avaliação da percepção da fadiga na população portuguesa de doentes com Lúpus Eritematoso Sistémico. Relativamente à validade de constructo, os resultados revelam que quanto mais intensa a fadiga percepcionada pelos doentes com LES, pior a qualidade de vida em todos os domínios (físico, psicológico, relações sociais e meio ambiente) e maior a sintomatologia depressiva e ansiosa apresentada. Palavras-chave: Fadiga Intensa, Lúpus Eritematoso Sistémico, Morbilidade Psicológica, Qualidade de Vida. _________________________________________________________________________________________________________________________________ SEVERE FATIGUE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: A STUDY ON THE PSYCHOMETRIC PROPERTIES OF THE SEVERITY FATIGUE SCALE ABSTRACT:The main purpose of this study was the adaptation of the Fatigue Severity Scale (Krupp et al., 1989), which was designed to assess the perception of fatigue levels in patients with Systemic Lupus Erythematosus (SLE). Using a sample of 104 patients with SLE, the results showed that the Fatigue Severity Scale had a fidelity coefficient of .96, which indicates a high internal consistency of the items, like the original version (.88). The factor analysis showed the items, in the adapted version, to be organized in one factor only, as it happens in the original version. Thus, the Fatigue Severity Scale has good psychometric qualities that allow its use as an assessment tool in the evaluation the perception of fatigue in the Portuguese population of patients with Systemic Lupus Erythematosus. In terms of construct validity results showed, in patients with SLE, higher perceived fatigue to be associated with low quality of life in every domain (physical, psychological, social relationships and environment) and more depressive and anxiety symptoms.

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Systemic lupus erythematosus in three ethnic groups. VI: Factors associated with fatigue within 5 years of criteria diagnosis

Cited by 125 publications

References 32 publications

Evidence for aerobic insufficiency in women with systemic lupus erythematosus

Evidence for aerobic insufficiency in women with systemic lupus erythematosus

Systemic lupus erythematosus in three ethnic groups: IX. Differences in damage accrual

Severe Fatigue in Patients With Systemic Lupus Erythematosus: A Study on the Psychometric Properties of the Severity Fatigue Scale

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