Systemic mastocytosis

Korenblat, P.E.

doi:10.1001/archinte.144.11.2249

Cited by 30 publications

(5 citation statements)

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“…The negative and positive control mice were administered orally with PBS or montelukast (30 mg/kg in PBS), respectively. Montelukast was developed as a cysteinyl leukotriene (cys-LT)-1 receptor antagonist (17) and it was introduced into the market after successful clinical evaluation in patients with aspirin-sensitive asthma, nocturnal exacerbation of asthma and allergic asthma (18).…”

Section: Methodsmentioning

confidence: 99%

EBM84 attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma

Shin

Lee

Jeon

et al. 2013

International Journal of Molecular Medicine

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Abstract. EBM84 is a traditional herbal medicine and a combination of extracts obtained from Pinellia ternata and Zingiber officinale. It is traditionally used to treat vomiting, nausea, sputum and gastrointestinal disorders, and functions is an effective expectorant. In this study, we evaluated the protective effects of EBM84 on asthmatic responses, particularly mucus hypersecretion in an ovalbumin (OVA)-induced murine model of asthma. We also analyzed EBM84 composition using high performance liquid chromatography. Animals were sensitized on days 0 and 14 via intraperitoneal injection using 20 µg OVA. On days 21, 22 and 23 after initial sensitization, the mice received an airway challenge with OVA (1% w/v in PBS) for 1 h using an ultrasonic nebulizer (NE-U12). EBM84 was administered by gavage to the mice at doses of 16.9, 33.8 and 67.5 mg/kg once daily from days 18 to 23. EBM84 administration significantly lowered elevated levels of interleukin (IL)-4, IL-13, eotaxin and immunoglobulin (Ig)E in the bronchoalveolar lavage fluid or plasma. Airway inflammation and mucus hypersecretion were attenuated following EBM84 administration. EBM84 also inhibited the overexpression of mucin 5AC (MUC5AC) induced by OVA challenge in lung tissue. This result was consistent with the immunohistochemistry results. Our results indicate that EBM84 effectively inhibited airway inflammation and mucus hypersecretion via the downregulation of T helper 2 (Th2) cytokines, which reduced MUC5AC expression. Therefore, EBM84 has potential as a useful medicine for the treatment of allergic asthma.

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Section: Methodsmentioning

confidence: 99%

EBM84 attenuates airway inflammation and mucus hypersecretion in an ovalbumin-induced murine model of asthma

Shin

Lee

Jeon

et al. 2013

International Journal of Molecular Medicine

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“…The clinical diagnosis can be difficult in TMEP because it usually does not show the typical presentation of childhood mast cell diseases: yellowish‐tan papules that urticate on rubbing (Darier’s sign), like normal looking skin (dermatographism) 5,6 . The small number of mast cells within the lesions may explain the absence of both eosinophils and local signs, such as Darier and dermographism 7…”

Section: To the Editormentioning

confidence: 99%

Telangiectasia macularis eruptiva perstans

Ak¹,

Kotoğyan²

2001

Acad Dermatol Venereol

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“…In systemic mastocytosis, mast cells infiltrate into various organs including the liver, spleen and those in the skeletal, gastrointestinal, and lymphatic systems (1, 2). While it is uncommon for mastocytosis to affect the central nervous system, headache, dizziness, seizures, and alterations in cognitive function have been described previously (3, 4). However, the occurrence of chorea is extremely rare.…”

Section: To the Editormentioning

confidence: 97%

“…To examine the possible correlation between mastocytosis and chorea in our case, we determined whether an activator of mast cell secretion would provoke choreic movements. A number of agents, including polycations, alcohol, nonsteroidal anti‐inflammatory drugs (NSAIDs), anesthetics, opiates, and radio‐contrast dyes, are releasers of the mast cell mediators; opiates are the most potent (2, 4). After informed consent, 10 mg of codeine phosphate, a potent activator of mast cells, was administered under careful observation.…”

Section: To the Editormentioning

confidence: 99%