Systolic phases of the cardiac cycle in children

Golde, David W.; Burstin, L

doi:10.1016/0002-9149(69)90280-x

Cited by 6 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[6][7][8][9] At resting or low heart rates, systole constitutes ≈40% of the cardiac cycle in healthy children. 6 Conversely, in ventricular dysfunction of various causes, including DCM, systole prolongs and concomitantly diastole shortens.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Implications of the Systolic to Diastolic Duration Ratio in Children With Idiopathic or Familial Dilated Cardiomyopathy

Mondal

Slorach

Manlhiot

et al. 2014

Circ: Cardiovascular Imaging

View full text Add to dashboard Cite

All children, 0 to 18 years of age, registered in the pediatric heart failure database with a diagnosis of idiopathic, genetic, or familial DCM and who received their initial echocardiogram at our institution Background-Childhood dilated cardiomyopathy (DCM) carries high morbidity and mortality. The echocardiographic systolic to diastolic (S:D) duration ratio, an indicator of global cardiac performance, is elevated in DCM; however, its prognostic implications have not been investigated in this population. Methods and Results-We investigated systolic and diastolic durations and the resultant S:D ratio using pulsed tissue Doppler imaging in children with idiopathic or familial DCM. We studied serial echocardiograms from presentation until the last follow-up echo. Results were compared with heart rate-matched controls and between DCM subgroups based on an acute or insidious presentation. The association between S:D ratio and death or need for transplant was analyzed. All analyses were adjusted for repeated measures per patient. We studied 200 serial echocardiograms of 48 children with DCM (7.0±6.0 years) and 25 controls. Adjusted for repeated measures through a compound symmetry covariance structure, the S:D ratio was higher in DCM patients (−0.425 [0.072]; P<0.001) because of shortened diastole. A S:D ratio >1.2 at presentation and on serial evaluation was associated with a hazard ratio of 10.5 (95% confidence interval, 3.9-27.8; P<0.001) for death or transplant. In combined multivariable analysis, a S:D ratio >1.2 remained significantly associated with hazard of death/transplant (hazard ratio, 9.1; P=0.04) after adjustment for ejection fraction (hazard ratio: 2.2 per −10%; P<0.001). Conclusions-A high S:D ratio is associated with increased risk for death or need for transplant in children with DCM across the spectrum of heart rates and may be a useful prognostic index for serial evaluation of children with DCM.(Circ Cardiovasc Imaging. 2014;7:773-780.)

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic Implications of the Systolic to Diastolic Duration Ratio in Children With Idiopathic or Familial Dilated Cardiomyopathy

Mondal

Slorach

Manlhiot

et al. 2014

Circ: Cardiovascular Imaging

View full text Add to dashboard Cite

show abstract

“…Previous studies in normal children have been confined to the measurement of LVSTI. [10][11][12] The echocardiogram provides a reliable and sensitive method of measuring left ventricular ejection. Data obtained from this study indicated that LVSTI derived from the aortic valve echo were reproducible and demonstrated excellent correlation with simultaneous measurements from arterial pulse tracings.…”

Section: Discussionmentioning

confidence: 99%

Measurement of right and left ventricular systolic time intervals by echocardiography.

Hirschfeld¹,

Meyer²,

Schwartz³

et al. 1975

Circulation

164

View full text Add to dashboard Cite

Three LVSTI are conventionally measured:'`3 total electromechanical systole (QS2), the left ventricular ejection time (LVET), and the pre-ejection period (PEP). QS2 is defined from the onset of ventricular depolarization (Q wave of ECG) to the initial high frequency vibraton of the aortic component of the second heart sound. LVET is derived from the onset of the upstroke of the carotid pulse to the incisural Received June 19, 1974; revision accepted for publication October 10, 1974. 304 notch, and PEP is obtained indirectly by subtracting LVET from QS2. To date, noninvasive assessment of right ventricular performance by measurement of STI has not been possible because of the inability to define accurately the onset of right ventricular ejection. The purpose of this study was to demonstrate that right, as well as left, ventricular STI can be measured noninvasively by the use of ultrasound. In addition, patients with transposition of the great arteries (TGA) were studied because they have a unique reversal of systemic and pulmonic vascular circuits, which permitted evaluation of the effect of this reversal on RV and LVSTI. MethodsThe echocardiograms were obtained with a Hoffrel 101 ultrasonoscope. Simultaneous strip chart recordings of the echocardiogram, phonocardiogram, carotid pulse tracing and ECG were obtained with a Cambridge Multichannel Physiological Recorder, Amplifier Type 72352.The ECG lead which most clearly demonstrated early ventricular depolarization, usually the Q wave, was chosen for timing the onset of electrical systole. The phonocardiogram was recorded with a piezo-electric, high impedance microphone having a frequency band of 100 to 600 cycles per second. Recordings were made at the base of the heart in the higher frequency sound spectrum.The carotid pulse measuring equipment consisted of an electronic amplifier driven by a piezo-electric pulse transducer. The sensing device is a plastic cone connected

show abstract

“…The tendency of lengthening of STI seems to continue in the elderly who have longer LVET (Willems et al, 1970) and QS2 (Slodki, Hussain and Luisada, 1969). No significant difference in STI between sexes was found in children (Golde and Burstin, 1970;Cantor et al, 1978) and in adolescents (Wanderman et al, 1981). In the adult, the differences in the regression equations for the sexes were significant for QS2 and LVET, but not for PEP .…”

Section: Physiological Variations Of Systolic Time Intervals Effect Omentioning

confidence: 92%

Systolic time intervals: a review of the method in the non-invasive investigation of cardiac function in health, disease and clinical pharmacology

Hassan

Turner

1983

Postgraduate Medical Journal

View full text Add to dashboard Cite

Systolic phases of the cardiac cycle in children

Cited by 6 publications

References 0 publications

Prognostic Implications of the Systolic to Diastolic Duration Ratio in Children With Idiopathic or Familial Dilated Cardiomyopathy

Prognostic Implications of the Systolic to Diastolic Duration Ratio in Children With Idiopathic or Familial Dilated Cardiomyopathy

Measurement of right and left ventricular systolic time intervals by echocardiography.

Systolic time intervals: a review of the method in the non-invasive investigation of cardiac function in health, disease and clinical pharmacology

Contact Info

Product

Resources

About