Systolic time intervals: a review of the method in the non-invasive investigation of cardiac function in health, disease and clinical pharmacology

Hassan, S.; Turner, Paul

doi:10.1136/pgmj.59.693.423

Cited by 72 publications

(46 citation statements)

References 65 publications

(115 reference statements)

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“…The observed changes in STIs might therefore be a composite of positive inotropic and afterload reducing actions, since both actions induce similar changes in the STI parameters (Hassan & Turner, 1983). Our data shows a dose-dependent increase in systolic blood pressure associated with a fall in diastolic blood pressure, particularly after 60 mg.…”

Section: Pharmacokineticssupporting

confidence: 52%

The effect of a new inotropic agent, DPI 201‐106, on systolic time intervals and the electrocardiogram in healthy subjects.

Rüegg¹,

Nüesch²

1987

Brit J Clinical Pharma

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1 DPI 201-106 (DPI) is a novel inotropic agent, with Na+ channel agonistic action combined with a sensitization of contractile proteins to Call. In a double-blind trial in healthy volunteers (n = 20) cardiovascular effects (blood pressure, heart rate, ECG) of single oral doses were studied. In addition systolic time intervals (STIs) were assessed in 10 of these subjects. DPI plasma concentrations were measured by h.p.l.c. 2 Preejection period was shortened by 14 ms (P < 0.01) and 30 ms (P < 0.01) 1 h after 30 and 60 mg, respectively, suggesting a dose-dependent inotropic effect. Heart rate was slightly reduced after both doses. Mean blood pressure remained unchanged. 3 Corrected QT interval duration (QTc) was prolonged by a mean of7 ms (NS) and 22 ms (P < 0.001) 1 h after 30 and 60 mg, respectively. PQ and QRS intervals remained unaffected. 4 Peak plasma levels were attained at 1-2 h and the terminal elimination half-life was approximately 15 h. 5 It is concluded that DPI has positive inotropic and negative chronotropic properties which make it potentially useful for the treatment of heart failure.

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Section: Pharmacokineticssupporting

confidence: 52%

The effect of a new inotropic agent, DPI 201‐106, on systolic time intervals and the electrocardiogram in healthy subjects.

Rüegg¹,

Nüesch²

1987

Brit J Clinical Pharma

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“…The systolic indices of cardiac performance were measured by the use of pre-ejection period/left ventricular ejection time (PEP/LVET), according to Hassan & Turner (1983) (PEP/ LVET ratio in a normal adult (0.35 in our laboratory).…”

Section: Histologicalmentioning

confidence: 99%

Weekly chemotherapy in advanced prostatic cancer

Francini

Petrioli²,

Manganelli³

et al. 1993

Br J Cancer

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Summary This randomised phase II study was performed in order to evaluate the effectiveness of a weekly chemotherapy regimen in advanced prostatic carcinoma patients (stage D2) refractory to hormonal therapy. Seventy-two cases were studied: they were randomised in a 2:1 ratio to receive either epirubicin (30 mgm 2 weekly) or doxorubicin (25 mg m weekly); 48 patients received epirubicin and 24 received doxorubicin.After 12 courses of chemotherapy, the 45 evaluable patients in the epirubicin arm showed a response rate of 37.7% and the 21 evaluable patients in the doxorubicin arm showed a response rate of 33.3% (P = 0.51) Pain intensity, bone and prostatic tumour markers rapidly and significantly decreased in responders. An improvement in physical symptoms, functional conditions and in emotional well-being was observed in the majority of the treated patients.The histological analysis of bone metastases, performed before and after 12 courses of chemotherapy showed a significant reduction in neoplastic invasion and in new bone formation in responders.Cardiac performance worsened in five out of 45 patients and in ten out of 21 during the first 12 courses of epirubicin or doxorubicin respectively (P = 0.014).The median survival was 12.5 months in the epirubicin arm and 8.0 months in the doxorubicin arm (P = 0.042).Our data indicate that in advanced prostatic carcinoma, a weekly epirubicin regimen may give rapid palliative results, similar to that of doxorubicin, but with less side-effects.

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“…Because of the difficulties of measuring CO, surrogate measures such as systolic time intervals (Hassan et al, 1983) or peak aortic blood velocity (Harry et al, 1988) have been used instead. There are now available two devices which measure CO noninvasively using different principles; these are the Bomed NCCOM3-R7, which uses transthoracic electrical bioimpedance (TEB) (Sramek, 1981), and the Quantascope (Vital Science) which uses a nonimaging Doppler ultrasound method .…”

Section: Doppler Reproducibilitymentioning

confidence: 99%

Comparison and reproducibility of transthoracic bioimpedance and dual beam Doppler ultrasound measurement of cardiac function in healthy volunteers.

Ng¹,

Walley²,

Tsao³

et al. 1991

Brit J Clinical Pharma

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Systolic time intervals: a review of the method in the non-invasive investigation of cardiac function in health, disease and clinical pharmacology

Cited by 72 publications

References 65 publications

The effect of a new inotropic agent, DPI 201‐106, on systolic time intervals and the electrocardiogram in healthy subjects.

The effect of a new inotropic agent, DPI 201‐106, on systolic time intervals and the electrocardiogram in healthy subjects.

Weekly chemotherapy in advanced prostatic cancer

Comparison and reproducibility of transthoracic bioimpedance and dual beam Doppler ultrasound measurement of cardiac function in healthy volunteers.

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