T cell disorders in primary immunodeficiency diseases

Waldmann, Thomas A.; Broder, Samuel

doi:10.1007/bf01891816

Cited by 12 publications

(4 citation statements)

References 68 publications

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“…There is general agreement in these studies that there is ab sence of circulating B cells with the presence of pre-B cells in the bone marrow of XLA patients [92]. The T cell studies in XLA have generally demonstrated slightly increased percentage of total T cells which is probably compensatory resulting from the absent B cells; ihe CD4 and CD8 distribution appears to be normal [93][94][95][96][97].…”

Section: Immunodeficiency Disorderssupporting

confidence: 63%

“…Cel lular phenotyping in certain of these disor ders has also proven useful in identifying functional correlates for cell-surface mark ers. In severe combined immunodeficiency, cell identification helped to clarify that this disorder represents more than one process at the cellular level since some patients have B cells while others have markedly depressed B cells as well as T cells [92]. Studies of the DiGeorge syndrome have demonstrated that B cell numbers arc normal while circulating T cells are generally very low [93][94][95].…”

Section: Immunodeficiency Disordersmentioning

confidence: 99%

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Application of Lymphocyte Immunophenotyping in Selected Diseases

Marti

Fleisher

1988

Path Immunopathol Res

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Section: Immunodeficiency Disorderssupporting

confidence: 63%

Section: Immunodeficiency Disordersmentioning

confidence: 99%

Application of Lymphocyte Immunophenotyping in Selected Diseases

Marti

Fleisher

1988

Path Immunopathol Res

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“…supramammary lymph nodes showed heightened responsiveness suggesting the presence of regional differences in T cell regulatory mechanisms, perhaps reflecting quantitative and qualitative differences in CD4 helper/CD8 suppressor T cell subsets (14-18) . nodes may be attributed to increased proportions of CD8 suppressor T cell precursors or already activated suppressor cells (19,20), several investigators have demonstrated the suppressive capabilities of B cells and macrophages in other species (21)(22)(23)(24). Thus, to investigate the potential differences in immunoregulation among peripheral (supramammary) and mesenteric BCE populations and their possible effects on T cell interaction studies, mixed co-cultures using T and responding BCE populations from supramammary and mesenteric lymph nodes were performed.…”

Section: Discussionmentioning

confidence: 98%

Size, CD4 and CDS Marker Profiles and Functions of Lymphocyte Subpopulations in Mucosal-Associated Lymph Nodes

Dobrzanski

Yang

1991

Immunological Investigations

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We analyzed phenotypic and functional characteristics of T cell populations in mucosal-associated supramammary and mesenteric lymph nodes in goats. Here we demonstrate, by flow cytometry, quantitative differences in CD4 and CD8 T cell subsets among large and small mucosal-associated lymphocyte populations and their differential regulatory activities on resident lymph node B cells stimulated with Staphylococcus aureus Cowan I or pokeweed mitogen. The CD4/CD8 T cell ratio was lower in mesenteric lymph nodes (1.46) when compared to that of supramammary lymph nodes (2.18). Analysis of large and small lymphocyte subpopulations from lymph nodes showed nearly 62% of the lymphocytes from mesenteric lymph nodes being of large cell phenotype with CD4/CD8 ratios of 1.34. In contrast, large cell subpopulations in supramammary lymph nodes showed a significantly lower number (50%) with a higher CD4/CD8 ratio of 2.05. Functionally, mesenteric lymph node T cells, isolated by nylon wool, showed heightened suppressive activity in mitogen-driven B cell proliferation responses, whereas T cells from supramammary lymph nodes were stimulatory. These findings clearly demonstrate distinctive functional properties between resident T cell populations of supramammary and mesenteric lymph nodes, suggesting that different proportions of T cell subsets in these nodes are activated and thus regulate regional immune responses via different pathways.

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“…Abbreviations SCID, severe combined immunodeficiency MNL, mononuclear cells PWM, pokeweed mitogen NK, natural killer HBSS, Hanks' balanced salt solution Ig-SC, immunoglobin-secretingcells HEPES, 4-(2-hydroxyethyl)-l-piperazineethanesulfonic acid EBV, Epstein-Barr virus PHA, phytohemagglutinin Con A, concanavalin A SK-SD, streptokinase-streptodornase WBC, white blood cells SCID encompasses a heterogeneous group of congenital disorders which manifest varying degrees of dysfunction of both B and T lymphocytes (28). Although the majority of patients lack adequate numbers and function of both T and B lymphocytes, a minority of patients has been identified with normal circulating numbers of these cell populations (6,10,21,22).…”

Section: Discussionmentioning

confidence: 99%