T Cell/Histiocyte-Rich Large B Cell Lymphoma of the Thymus: A Diagnostic Pitfall

Xu, Jie; Wu, Xiaojun; Reddy, V.

doi:10.1155/2016/2942594

Cited by 8 publications

(10 citation statements)

References 22 publications

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“…In the present case, malignant B-cells were positive for CD20 and Bcl-2 and negative for CD30, and the reactive background infiltrate was positive for CD5, CD45RO and CD68. This corroborates the immunohistochemical findings reported in the literature for THRLBCL in other locations [8,[21][22][23][24][25][26][27]. The immunohistochemistry findings in the present case were fundamental to the direction of the final diagnosis of this rare variant of DLBCL localized in the jaw, owing to the similarity of the clinical and radiographic characteristics of this case with those of other typical cases of DLBCL described in the literature [13,16].…”

Section: Discussionsupporting

confidence: 90%

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: Report of the First Case in the Mandible

Rnf

Batista

et al. 2018

Head and Neck Pathol

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T-cell/histiocyte-rich large B-cell lymphoma (THRBCL) is an uncommon subtype of non-Hodgkin's lymphoma. It is a predominant nodal neoplasm; however, extranodal sites, such as the spleen, liver and bone marrow, can be involved at diagnosis. However, only one case of primary THRLBCL in the jaws have been reported. We herein describe a 29-year-old female patient who presented with a swelling of the right mandible that had grown rapidly over the previous 2 months. Periapical and panoramic radiographs showed a multilocular osteolytic lesion located in the mandibular periapical region of the canine and premolar teeth and molar region. Preoperative examination and incisional biopsy were performed. Immunohistochemistry was applied to confirm the diagnosis of THRBCL in the jaw. The treatment consisted of CHOP therapy and radiotherapy. After complete tumor remission following initial treatment, additional sites of the disease appeared in the lung, abdomen and long bones. The patient died within 2 months. THRLBCL is an uncommon and aggressive malignant neoplasm that can involve the jaws, mimicking a periapical disease.

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Section: Discussionsupporting

confidence: 90%

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: Report of the First Case in the Mandible

Rnf

Batista

et al. 2018

Head and Neck Pathol

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“…present with non-specific pulmonary symptoms or an unclear history of precedential lymphomas, which is consistent with previous studies (19,20). The present study demonstrated that CT features may assist in the diagnosis of PPL and SPL with regard to tumor morphology and location, and lymph node involvement, but not with regard to the SUV max of PET/CT.…”

Section: Predicted Diagnosis Based On Radiographic Features Actual DIsupporting

confidence: 91%

Significance of imaging and clinical features in the differentiation between primary and secondary pulmonary lymphoma

et al. 2017

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Abstract. The aim of the present study was to analyze the differences in imaging and clinical features between primary pulmonary lymphoma (PPL) and secondary pulmonary lymphoma (SPL) to provide insight into pulmonary lymphoma for an improved clinical diagnosis. A retrospective study of 38 patients with pulmonary lymphoma (19 PPL and 19 SPL) treated between September 1, 2006, and December 31, 2015, was performed. The clinical manifestations, and computed tomography (CT) and positron emission tomography-CT images of each case were collected. χ 2 and Fisher's exact tests were applied to assess statistically significant differences between PPL and SPL in terms of clinical and imaging features. The significant variables were further applied to canonical discriminate analysis. The CT results revealed that the occurrence of a >3-cm mass (P=0.007), peripheral location (lower than the segmental bronchi) (P=0.027), cavitation (P=0.008) and consolidation (P=0.027) were associated with PPL, while peripheral and hilar location (P=0.003) or mediastinal and hilar lymph node engagement (P=0.044) were predominantly observed in SPL. However, no significant differences between clinical manifestations and the maximum standard uptake value of pulmonary lesions in PPL and SPL were identified (all P>0.05). A function derived from discriminate analysis was generated that may predict the affiliation to PPL or SPL radiographically, with an overall accuracy of ≤92.1%. The results of the present study revealed that PPL and SPL exhibit distinctive features on CT images due to distinct molecular mechanisms and growth patterns. Careful observation of CT features may be useful in the diagnosis of PPL and SPL regarding the tumor morphology, location and lymph node involvement. IntroductionPulmonary lymphomas may occur as a primary pulmonary malignancy or a secondary manifestation derived from systemic lymphoma (1). Primary pulmonary lymphomas (PPLs) are defined as malignant lymphomas originating from pulmonary parenchyma or bronchi with or without hilar lymph node involvement, in the absence of tumor dissemination for ≥3 months after the diagnosis (2,3). Prevalence ranges between 0.5 and 1% of PPL malignancies and accounts for <1% of malignant lymphomas (4). The rarity of PPL may be attributed to pulmonary tissue containing less lymphoid tissue compared with other sites. The most common type of PPL is mucosa-associated lymphoid tissue (MALT) lymphoma (70-90%), with the remainder comprising a miscellaneous group that includes non-Hodgkin low-grade extra-nodal B-cell lymphoma (NHL-B), high-grade diffuse large B-cell lymphoma (DLBCL) (5-20%), primary pulmonary Hodgkin's lymphoma and certain other extremely rare diseases (5-7). Secondary pulmonary lymphoma (SPL), which is more common than PPL, refers to a secondary involvement of the lung from a known extra-pulmonary lymphoma or dominant pulmonary lesion, with indolent primary extra-pulmonary lesions observed within 3 months (8).These two origins of pulmonary lymphoma distinguish themselves patho...

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“…T/HRBCL is a nodal disease, but extralnodal sites, such as spleen, liver and bone marrow can be involved[ 10 - 12 , 20 , 21 ]. In recent reports, primary cutaneous[ 22 ], thyroid[ 23 ], thymus[ 24 ], and gastrointestinal presentations[ 25 , 26 ] of T/HRBCL were also described. To date, pancreatic involvement of T/HRBCL has not been reported.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic T/histiocyte-rich large B-cell lymphoma: A case report and review of literature

Zheng

Zhou

Chen

et al. 2017

WJG

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Primary pancreatic lymphoma (PPL) is an extremely rare form of extranodal malignant lymphoma. The most common histological subtype of PPL is diffuse large B cell lymphoma (DLBCL). In rare cases, PPL can also present as follicular lymphoma, small lymphocytic lymphoma, and T cell lymphoma either of non-Hodgkin’s lymphoma or of Hodgkin’s lymphoma. T-cell/histiocyte-rich large B-cell lymphoma (T/HRBCL) is an uncommon morphologic variant of DLBCL with aggressive clinical course, it is predominantly a nodal disease, but extranodal sites such as bone marrow, liver, and spleen can be involved. Pancreatic involvement of T/HRBCL was not presented before. Herein, we report a 48-year-old male who was hospitalized with complaints of jaundice, dark brown urine, pale stools, and nausea. The radiological evaluation revealed a pancreatic head mass and, following operative biopsy, the tumor was diagnosed as T/HRBCL. The patient achieved remission after six cycles of CHOP chemotherapy. Therefore, T/HRBCL can be treated similarly to the stage-matched DLBCL and both of them get equivalent outcomes after chemotherapy.

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T Cell/Histiocyte-Rich Large B Cell Lymphoma of the Thymus: A Diagnostic Pitfall

Cited by 8 publications

References 22 publications

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: Report of the First Case in the Mandible

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: Report of the First Case in the Mandible

Significance of imaging and clinical features in the differentiation between primary and secondary pulmonary lymphoma

Pancreatic T/histiocyte-rich large B-cell lymphoma: A case report and review of literature

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