T cell reactivity in neonates from an East and a West German city – results of the LISA study

Lehmann, Irina; Thoelke, Adina; Weiß, Michael; Schlink, Uwe; Schulz, R.; Diez, Ulrike; Sierig, Gabriele; Emmrich, Frank; Jacob, B.; Belcredi, Petra; Bolte, Gabriele; Heinrich, Joachim; Herbarth, Olf; Wichmann, H‐Erich; Borte, Michael

doi:10.1046/j.0105-4538.2002.00001.x

Cited by 47 publications

(28 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Diese betreffen insbesondere die T-Lymphozyten [31,32]. Da die festgestellten verminderten TH 1 -und erhöhte TH 2 -Zahlen im Nabelschnurblut mit einem erhöhten Risiko für das Auftreten eines atopischen Ekzems in den ersten beiden Lebensjahren assoziiert waren [33], kann davon ausgegangen werden, dass Chemikalienbelastungen im Innenraum wäh-rend der Schwangerschaft ein Risiko für das spätere Auftreten von Allergien beim Kind darstellen.…”

Section: Innenraumbelastungenunclassified

Die zwei deutschen Geburtskohorten GINIplus und LISAplus

Heinrich

Brüske

Schnappinger

et al. 2012

Bundesgesundheitsbl.

Self Cite

View full text Add to dashboard Cite

Numerous chronic diseases in childhood and adulthood have their origins in perinatal life and are potentially influenced by trans-generational epigenetic processes. Therefore, prospective birth cohorts can substantially contribute to our knowledge about the etiology of diseases including modifiable risk factors. The two population-based German birth cohorts GINIplus and LISAplus aim to describe the natural course of chronic diseases and intermediate phenotypes in childhood and its determinants, and to identify potential genetic effect modifications. In the mid-1990s, 5,991 (GINIplus) and 3,097 (LISAplus) healthy, term newborns were recruited for long-term follow-up in four regions of Germany. The follow-up rate for the first 10 years was about 55%. We analyzed the growth and development of overweight, infections and allergic diseases, mental and oral health, metabolic and inflammatory parameters and the role of potential risk factors including genetics. The results of these two birth cohorts substantially contribute to the current knowledge about the natural course of these health parameters. These data were included in many international projects and consortia for purposes of international comparisons of prevalence and consistency of findings, and to increase the power of the analyses.

show abstract

Section: Innenraumbelastungenunclassified

Die zwei deutschen Geburtskohorten GINIplus und LISAplus

Heinrich

Brüske

Schnappinger

et al. 2012

Bundesgesundheitsbl.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Da in München deutlich häufiger eine doppelt positive Familienanamnese vorliegt und während der Schwangerschaft häufiger renoviert wurde, wird dies als eine Erklä-rung für die Unterschiede in der T-ZellImmunität zwischen Leipzig und Mün-chen diskutiert. Wegen der kleinen Fallzahl sind jedoch weitreichende Schlussfolgerungen nur mit großer Zurückhaltung zu ziehen [16,17].…”

Section: Introductionunclassified

Einfluss von Lebensbedingungen und Verhaltensweisen auf die Entwicklung von Immunsystem und Allergien im Ost-West-Vergleich (LISA)

Brockow

Zutavern

Franke³

et al. 2007

Monatsschr Kinderheilkd

Self Cite

View full text Add to dashboard Cite

“…Prenatal exposures to modern chemicals of indoor origin (emitted from building material, consumer product uses, and/or lifestyle-related products) within a damp home indoor environment (contributed by structural water damage, poor ventilation, and/or low temperature) contribute to altered development of fetal innate and adaptive immune system cells (21,(23)(24)(25)(26). The indoor environment during early life (i.e.…”

Section: Home Indoor Dampnessmentioning

confidence: 99%

Linking childhood allergic asthma phenotypes with endotype through integrated systems biology: current evidence and research needs

Choi

Song

Zhang

2017

Reviews on Environmental Health

View full text Add to dashboard Cite

Abstract Asthma and other complex diseases results from a complex web of interactions involving inflammation, immunity, cell cycle, apoptosis, and metabolic perturbations across multiple organ systems. The extent to which various degrees of the age at onset, symptom severity, and the natural progression of the disease reflect multiple disease subtypes, influenced by unique process of development remains unknown. One of the most critical challenges to our understanding stems from incomplete understanding of the mechanisms. Within this review, we focus on the phenotypes of childhood allergic asthma as the basis to better understand the endotype for quantitative define subtypes of asthma. We highlight some of the known mechanistic pathways associated with the key hallmark events before the asthma onset. In particular, we examine how the recent advent of multiaxial -omics technologies and systems biology could help to clarify our current understanding of the pathway. We review how a large volume of molecular, genomic data generated by multiaxial technologies could be digested to identify cogent pathophysiologic molecular networks. We highlight some recent successes in application of these technologies within the context of other disease conditions for therapeutic interventions. We conclude by summarizing the research needs for the predictive value of preclinical biomarkers.

show abstract

T cell reactivity in neonates from an East and a West German city – results of the LISA study

Abstract: Since differences in the T cell cytokine production of neonates in Munich and Leipzig are independent from FAH our findings may provide evidence for the impact of environmental factors upon the fetal immune system.

Cited by 47 publications

References 28 publications

Die zwei deutschen Geburtskohorten GINIplus und LISAplus

Die zwei deutschen Geburtskohorten GINIplus und LISAplus

Einfluss von Lebensbedingungen und Verhaltensweisen auf die Entwicklung von Immunsystem und Allergien im Ost-West-Vergleich (LISA)

Linking childhood allergic asthma phenotypes with endotype through integrated systems biology: current evidence and research needs

Contact Info

Product

Resources

About