T cells and liver fibrosis

Sun, Runyuan; Zheng, Xunhua; Wu, Bin

doi:10.1002/poh2.11

Cited by 4 publications

(2 citation statements)

References 91 publications

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“…These immune cells may be profibrotic or antifibrotic during fibrosis. 25,26 Weiss et al discovered that patients with acute chronic liver failure (ACLF) have dysregulation in systemic immune cells, including leukocytosis generated by neutrophils and monocyte subsets and decreased count associated with memory lymphocyte, CD8 T cell, and natural killer cell depletion. ACLF patients also developed decompensated cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Absolute Lymphocyte Count and Ascites in Patients with Liver Cirrhosis

Riyadi,

Carmelita,

Sasmithae

et al. 2024

InaJGHE

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Background: Cirrhosis is the final stage of liver disease characterized by fibrosis and irreversible nodule formation due to chronic inflammation. The most common liver cirrhosis complication is ascites, where pathological fluid accumulates in the peritoneal cavity. In cirrhosis, lymphocytes infiltrate the liver and contribute to stellate cell activation, differentiation, and the fibrogenic response. Many recent studies have not studied a relationship between the absolute lymphocyte count and ascites in liver cirrhosis. Therefore, it is important to investigate the relationship between lymphocytes and ascites in liver cirrhosis.Method: This is an observational study with a cross-sectional design study. Held in August–October 2022 at Dr. Doris Sylvanus Hospital's Medical Record Installation. 64 samples were selected based on inclusion and exclusion criteria. Meanwhile, absolute lymphocyte count were measured from the patient's blood tests or by calculation. Ascites were diagnosed by physical examination and radiology. The relationship between absolute lymphocyte count and ascites was analyzed using the chi-square test, with the results considered statistically significant when the p-value 0.05.Result: The medical records from April 2019 to April 2022, there were 64 samples, of which 15 and 49 were without and with ascites. Based on the chi-square test results, there was a significant relationship between absolute lymphocyte count and the incidence of ascites, with p = 0.02.Conclusion: This study concluded that there is a relationship between absolute lymphocyte count and ascites in patients with liver cirrhosis, where absolute lymphocyte count tends to decrease.

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Section: Discussionmentioning

confidence: 99%

Relationship between Absolute Lymphocyte Count and Ascites in Patients with Liver Cirrhosis

Riyadi,

Carmelita,

Sasmithae

et al. 2024

InaJGHE

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show abstract

“…On the contrary, a reduction of the number of CD8+ T cells had little effect on the progression of hepatic fibrosis in carbon tetrachloride-treated animals [21]. Given that spleen-derived CD8+ T cells induce liver fibrosis and that hepatic CD8+ T-cell depletion probably has no effect on liver fibrosis, various subtypes of CD8+ T-cell may be distributed differently in the spleen and liver of mice, playing distinct roles in liver fibrosis [22] (Figure 1).…”

Section: Update On the Correlated Pro-fibrotic Role Of Cd4+ And Cd8+ ...mentioning

confidence: 99%

Immune and Non-Immune Inflammatory Cells Involved in Autoimmune Fibrosis: New Discoveries

Sisto

Lisi

2023

JCM

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Fibrosis is an important health problem and its pathogenetic activation is still largely unknown. It can develop either spontaneously or, more frequently, as a consequence of various underlying diseases, such as chronic inflammatory autoimmune diseases. Fibrotic tissue is always characterized by mononuclear immune cells infiltration. The cytokine profile of these cells shows clear proinflammatory and profibrotic characteristics. Furthermore, the production of inflammatory mediators by non-immune cells, in response to several stimuli, can be involved in the fibrotic process. It is now established that defects in the abilities of non-immune cells to mediate immune regulation may be involved in the pathogenicity of a series of inflammatory diseases. The convergence of several, not yet well identified, factors results in the aberrant activation of non-immune cells, such as epithelial cells, endothelial cells, and fibroblasts, that, by producing pro-inflammatory molecules, exacerbate the inflammatory condition leading to the excessive and chaotic secretion of extracellular matrix proteins. However, the precise cellular mechanisms involved in this process have not yet been fully elucidated. In this review, we explore the latest discoveries on the mechanisms that initiate and perpetuate the vicious circle of abnormal communications between immune and non-immune cells, responsible for fibrotic evolution of inflammatory autoimmune diseases.

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Liver cirrhosis: molecular mechanisms and therapeutic interventions

Dong,

Wang,

Jin

2024

MedComm

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Liver cirrhosis is the end‐stage of chronic liver disease, characterized by inflammation, necrosis, advanced fibrosis, and regenerative nodule formation. Long‐term inflammation can cause continuous damage to liver tissues and hepatocytes, along with increased vascular tone and portal hypertension. Among them, fibrosis is the necessary stage and essential feature of liver cirrhosis, and effective antifibrosis strategies are commonly considered the key to treating liver cirrhosis. Although different therapeutic strategies aimed at reversing or preventing fibrosis have been developed, the effects have not be more satisfactory. In this review, we discussed abnormal changes in the liver microenvironment that contribute to the progression of liver cirrhosis and highlighted the importance of recent therapeutic strategies, including lifestyle improvement, small molecular agents, traditional Chinese medicine, stem cells, extracellular vesicles, and gut remediation, that regulate liver fibrosis and liver cirrhosis. Meanwhile, therapeutic strategies for nanoparticles are discussed, as are their possible underlying broad application and prospects for ameliorating liver cirrhosis. Finally, we also reviewed the major challenges and opportunities of nanomedicine‒biological environment interactions. We hope this review will provide insights into the pathogenesis and molecular mechanisms of liver cirrhosis, thus facilitating new methods, drug discovery, and better treatment of liver cirrhosis.

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T cells and liver fibrosis

Cited by 4 publications

References 91 publications

Relationship between Absolute Lymphocyte Count and Ascites in Patients with Liver Cirrhosis

Relationship between Absolute Lymphocyte Count and Ascites in Patients with Liver Cirrhosis

Immune and Non-Immune Inflammatory Cells Involved in Autoimmune Fibrosis: New Discoveries

Liver cirrhosis: molecular mechanisms and therapeutic interventions

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