T helper cell‑related cytokine gene polymorphisms and vitamin D pathway gene polymorphisms as predictors of survival probability in patients on renal replacement therapy

Świderska, Monika; Mostowska, Adrianna; Grzegorzewska, Alicja E.

doi:10.20452/pamw.2957

Cited by 8 publications

(19 citation statements)

References 16 publications

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“…In our retrospective studies, there were no associations between GC rs2298849 and age at RRT onset [32], gender [33], and survival evaluated either since the start of RRT or since birth [2]. GC rs2298849 was also not associated with chronic glomerulonephritis [29] or type 2 diabetic nephropathy [30] as causes of ESRD.…”

Section: Discussionmentioning

confidence: 99%

“…Genotyping of vitamin D signaling pathway genes (VDR rs2228570, VDR rs1544410, RXRA rs10776909, RXRA rs10881578, RXRA rs749759, GC rs2298849, GC rs7041, and GC rs1155563) was performed as previously described [2, 24, 28–31]. …”

Section: Methodsmentioning

confidence: 99%

“…Cardiovascular diseases, infections, and cancers are the most common causes of death in this group of patients [1, 2]. …”

Section: Introductionmentioning

confidence: 99%

“…However, VDR polymorphisms (BsmI and FokI) showed no impact on ninety-day survival rate of acute kidney injury patients [23]. GC , VDR , and RXRA polymorphisms were not associated with risk of death in patients on RRT in our retrospective analysis [2]. CASR polymorphic variants had no impact on all-cause and cardiovascular mortalities in HD patients as well as on the occurrence of cardiovascular events and all-cause mortality in renal transplant recipients in retrospective studies [24, 25].…”

Section: Introductionmentioning

confidence: 99%

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Polymorphisms of Vitamin D Signaling Pathway Genes and Calcium-Sensing Receptor Gene in respect to Survival of Hemodialysis Patients: A Prospective Observational Study

Grzegorzewska

Świderska

Mostowska

et al. 2016

International Journal of Endocrinology

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We evaluated in the 7-year prospective study whether variants in vitamin D pathway genes and calcium-sensing receptor gene (CASR) are determinants of mortality in hemodialysis (HD) patients (n = 532). HRM analysis was used for GC rs2298849, GC rs1155563, RXRA rs10776909, RXRA rs10881578, and CASR rs7652589 genotyping. GC rs7041, RXRA rs749759, VDR rs2228570, and VDR rs1544410 were genotyped using PCR-RFLP analysis. The minor allele in GC rs2298849 was associated with all-cause mortality in univariate analysis (HR 1.330, 95% CI 1.046–1.692, P = 0.020). Bearers of the minor allele in GC rs2298849 demonstrated higher infection/neoplasm mortality than major allele homozygotes also in multivariate analysis (HR 2.116, 95% CI 1.096–4.087, P = 0.026). Cardiovascular mortality was associated with major homozygosity (CC) in VDR rs2228570 (HR 1.896, 95% CI 1.163–3.091, P = 0.010). CC genotype patients were more often dyslipidemic than TT genotype subjects (46.1% versus 31.9%, P = 0.047). Dyslipidemics showed higher frequency of rs1544410_rs2228570 haplotype AC than nondyslipidemics (26 versus 18%, P corr = 0.005), whereas TT genotype patients were at lower risk of dyslipidemia compared with CC/CT genotype patients (HR 0.59, 95% CI 0.37–0.96, P = 0.04). In conclusion, GC rs2298849 and VDR rs2228570 SNPs are associated with survival on HD. VDR-related cardiovascular mortality may occur due to connections of rs2228570 with dyslipidemia.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Cardiovascular diseases, infections, and cancers are the most common causes of death in this group of patients [1, 2]. …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polymorphisms of Vitamin D Signaling Pathway Genes and Calcium-Sensing Receptor Gene in respect to Survival of Hemodialysis Patients: A Prospective Observational Study

Grzegorzewska

Świderska

Mostowska

et al. 2016

International Journal of Endocrinology

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“…This finding is not a surprise. Diabetic patients show shorter life expectancy among HD subjects [46], and diabetes is an established predictor of mortality in HD patients [25]. Therefore, HD subjects with type 2 diabetic nephropathy may present worse satisfaction with various aspects of life, worse mood and more fear.…”

Section: Discussionmentioning

confidence: 99%

Self-Reported Physical Activity, Quality of Life, and Psychological Status in Relation to Plasma 25-Hydroxyvitamin D Concentration in Patients Treated with Hemodialysis

Grzegorzewska

Izdebska

Niepolski³

et al. 2016

Kidney Blood Press Res

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Background/Aims: Vitamin D status is announced among factors that may influence physical performance and mental health. Our aim was to evaluate self-reported physical activity, quality of life, psychiatric functioning, and affects with respect to plasma 25-hydroxyvitamin D [25(OH)D] concentrations in HD patients. Methods: The study was carried out in HD patients not receiving vitamin D supplements (n = 112). IPAQ-L, QLI-D, GHQ-28, and PANAS were used in psychological evaluations. Plasma 25(OH)D concentration was determined by a chemiluminescent microparticle immunoassay. Results: Plasma 25(OH)D level was suboptimal in all patients (14.6 ± 4.1 ng/ml). Adjusted correlates of 25(OH)D concentration included the GG genotype of GC rs7041 (β±SE: 1.77± 0.70, P=0.014), female sex (β±SE: -2.19±0.75, P=0.004), and treatment with high flux HD (β±SE: 2.59±0.69, P=0.0003). In adjusted analyses, circulating 25(OH)D showed the independent association with total activity related to domestic and gardening domain (β±SE: 53.2±23.8, P=0.028), and with moderate-intensity activities (β±SE: 54.9±27.4, P=0.048), but not with any of quality of life, psychiatric functioning, or affects measures. Conclusions: Vitamin D status is independently positively associated with physical activity in HD patients. Quality of life and mental health do not seem to be associated with circulating 25(OH)D under condition of its suboptimal levels.

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Antibodies to HBV surface antigen in relation to interferon-λ3 in hemodialysis patients

Grzegorzewska

Świderska

Mostowska

et al. 2016

Vaccine

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T helper cell‑related cytokine gene polymorphisms and vitamin D pathway gene polymorphisms as predictors of survival probability in patients on renal replacement therapy

Cited by 8 publications

References 16 publications

Polymorphisms of Vitamin D Signaling Pathway Genes and Calcium-Sensing Receptor Gene in respect to Survival of Hemodialysis Patients: A Prospective Observational Study

Polymorphisms of Vitamin D Signaling Pathway Genes and Calcium-Sensing Receptor Gene in respect to Survival of Hemodialysis Patients: A Prospective Observational Study

Self-Reported Physical Activity, Quality of Life, and Psychological Status in Relation to Plasma 25-Hydroxyvitamin D Concentration in Patients Treated with Hemodialysis

Antibodies to HBV surface antigen in relation to interferon-λ3 in hemodialysis patients

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