T-Lymphocyte and Cytokine Expression in Human Inflammatory Periapical Lesions

Brito, Luciana Carla Neves de; Teles, Flavia; Teles, Ricardo; Tótola, Antônio Helvécio; Vieira, Leda Quércia; Sobrinho, Antônio Paulino Ribeiro

doi:10.1016/j.joen.2011.12.010

Cited by 69 publications

(65 citation statements)

References 32 publications

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“…After pulp necrosis, microorganisms stimulate the migration of immune system cells to the periapical region where these cells trigger a series of reactions that involve the recruitment of other inflammatory cells and the release of proinflammatory and immunoregulatory cytokines and chemokines. 14,21 In this respect, an increasing number of studies have demonstrated the important role of viruses in the etiopathogenesis of periapical lesions, especially symptomatic and large lesions, but their exact role in the formation and development of these alterations remains uncertain.…”

Section: Discussionmentioning

confidence: 99%

“…These findings also suggest an important role of the adaptive immunity in the pathogenesis of chronic periapical lesions. 12,13,14,15 We emphasize that the integrity of the immune system is essential for the defense against infectious organisms and their toxic products. Immunodeficiency can compromise the number and activation of NK cells and CD8 + T lymphocytes, resulting in defects in the effector mechanisms of innate and adaptive immunity, thus leading to increased susceptibility for and difficulty in controlling infections.…”

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confidence: 99%

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Analysis of CD57+ natural killer cells and CD8+ T lymphocytes in periapical granulomas and radicular cysts

et al. 2017

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The aim of this study was to compare the number of CD57 + natural killer (NK) cells and CD8 + T lymphocytes between periapical granulomas (PGs) and radicular cysts (RCs). Twenty-fives cases of PGs and 25 of RCs were submitted to histological analysis and immunohistochemistry using anti-CD57 and anti-CD8 biomarkers. Positive cells were counted in 10 fields (400× magnification) and the median value was calculated for each case. Statistical tests were used to evaluate differences in the number of CD57+ NK cells and CD8 + T lymphocytes according to type of lesion, intensity of the infiltrate and thickness of the lining epithelium. The number of CD57 + NK cells and CD8 + T lymphocytes was higher in PGs than in RCs (p = 0.129 and p = 0.541, respectively). Comparison of the number of CD57 + NK cells in atrophic and hyperplastic epithelium revealed a larger number of cells in the atrophic epithelium (p = 0.042). A larger number of CD57 + NK cells and CD8 + T lymphocytes were observed in grade III infiltrates compared to grade I/II (p = 0.145 and p = 0.725, respectively). CD8 + T lymphocytes were more prevalent than CD57 + NK cells in most cases when PGs and RCs were analyzed separately or in combination (p < 0.0001). CD57+ NK cells and CD8 + T lymphocytes play a key role in antiviral defense and the presence of these cells supports evidence suggesting the participation of these microorganisms in the pathogenesis of PGs and RCs. The response mediated by CD8 + T lymphocytes was more frequent, indicating greater participation of the adaptive immunity in these chronic lesions.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Analysis of CD57+ natural killer cells and CD8+ T lymphocytes in periapical granulomas and radicular cysts

et al. 2017

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“…T lymphocytes are one of the key elements involved in apical periodontitis, considered the major sources of cytokines (1)(2)(3)7). These cells bear antigen-specific receptors on their cell surface to allow recognition of foreign pathogens (2).…”

mentioning

confidence: 99%

Clinical Influence of Different Intracanal Medications on Th1-type and Th2-type Cytokine Responses in Apical Periodontitis

Martinho

Nascimento

Leite

et al. 2015

Journal of Endodontics

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“…The reduction of IFN-γ, IL-1β and RANKL occurs from the reduction of bacterial load. Then, the increase of IL-10 is consistent with a decrease in pro-inflammatory response and it can perform a suppressor effect over periapical lesions (Brito et al, 2012).…”

Section: Pulpal and Periapical Infectionsmentioning

confidence: 69%

Antimicrobial peptide-based treatment for endodontic infections — Biotechnological innovation in endodontics

Lima

Pádua

Sousa

et al. 2015

Biotechnology Advances

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T-Lymphocyte and Cytokine Expression in Human Inflammatory Periapical Lesions

Cited by 69 publications

References 32 publications

Analysis of CD57+ natural killer cells and CD8+ T lymphocytes in periapical granulomas and radicular cysts

Analysis of CD57+ natural killer cells and CD8+ T lymphocytes in periapical granulomas and radicular cysts

Clinical Influence of Different Intracanal Medications on Th1-type and Th2-type Cytokine Responses in Apical Periodontitis

Antimicrobial peptide-based treatment for endodontic infections — Biotechnological innovation in endodontics

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