T1 Glottic Cancer: Does Anterior Commissure Involvement Worsen Prognosis?

Mannelli, Giuditta; Comini, Lara Valentina; Santoro, Roberto; Bettiol, Alessandra; Vannacci, Alfredo; Desideri, Isacco; Bonomo, Pierluigi; Piazza, Cesare

doi:10.3390/cancers12061485

Cited by 10 publications

(13 citation statements)

References 31 publications

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“…Tumor involvement of the AC has been cited as a potential prognostic factor for T1 glottic carcinoma, but no staging system has adopted it within their guidelines 8 . Previous authors have recognized the importance of adjusting guidelines to take into account AC involvement for staging T1 glottic cancers 2,9,20 . Despite the lack of recognition as an independent risk factor within the current AJCC guidelines, involvement of the AC drastically increases the risk of recurrence in both T1a and T1b glottic cancers 2,9,18,22 .…”

Section: Discussionmentioning

confidence: 99%

“…The Surveillance, Epidemiology, and End Results (SEER) program is an online database through the National Cancer Institute (NCI) and National Institutes of Health (NIH) that publishes cancer statistics in the United States. All previous studies comparing outcomes between T1a and T1b glottic cancers have been single‐institution retrospective studies with limited sample sizes 2,8,9 . For this study, we used the SEER database to compare Stage I T1a and T1b glottic cancers to evaluate differences in treatment and outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…All previous studies comparing outcomes between T1a and T1b glottic cancers have been singleinstitution retrospective studies with limited sample sizes. 2,8,9 For this study, we used the SEER database to compare Stage I T1a and T1b glottic cancers to evaluate differences in treatment and outcomes. The larger sample size provided by the SEER database is important for understanding the significant differences between these two groups.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic and Treatment Differences Between T1a and T1b Glottic Cancer

et al. 2022

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Objectives This study was designed to evaluate significant differences in treatment and survival outcomes between patients with T1a and T1b glottic cancer. Methods Patients within the SEER Research Plus, 18 Registries dataset who were diagnosed with Stage I T1a or T1b cancer of the glottis between 2004 and 2015 were included in this study. Data prior to 2004 could not be included, as the SEER database did not distinguish between T1a and T1b glottic cancer until that year. Results The 5‐year disease‐specific survival for T1a patients was significantly better than that of patients diagnosed with T1b glottic cancer. Age and year of diagnosis were also independent factors that impacted mortality. More patients who were diagnosed with T1b glottic cancer underwent external beam radiation than those diagnosed with T1a glottic cancer. Conclusion Our data shows that there are several independent factors effecting mortality including T classification, age at time of diagnosis, and year of diagnosis. T1a glottic cancers also show a significantly better prognosis compared with T1b. T1b glottic cancers are much more likely to be treated with primary radiotherapy compared with surgery. Level of Evidence 4 Laryngoscope, 132:2187–2193, 2022

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prognostic and Treatment Differences Between T1a and T1b Glottic Cancer

et al. 2022

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“…The available literature has demonstrated that the malignant tumors of the anterior commissure have a worse prognosis [24]. In these cases, the senior author's attitude is to perform a wide, subpericondrial excision and classify the procedure as a type VI cordectomy.…”

Section: Anterior Commissurementioning

confidence: 99%

Scanning Super/Ultrapulsed CO2 Laser Efficacy in Laryngeal Malignant Lesions

Dallari¹,

Giannoni

Filosa³

2022

Medicina

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Introduction: The authors review their experience in transoral laryngeal microsurgery (TLM) that they performed with two different CO2 laser devices from the same company, which were both equipped with a micromanipulator and digital scanner. Material and Methods: A total of 91 glottic and glotto-supraglottic cancers were treated during the years 2009–2016 and then analyzed in relation to the laser performances and the long-term oncologic results. Results: Laser devices proved to be very efficient and the UP mode was confirmed to be the best in terms of cutting precision and lowest thermal damage. Conclusions: CO2 laser TLM is the preferred option for the majority of small–medium size glottic and supraglottic cancers and may also be used for bigger tumors, especially in older patients.

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“…Baseline Characteristics of Old Patients (≥ 65 Years) different result may be attributed to the fact that Rutkowski et al enrolled only patients with T2 cancer.It is important to mention that patients afflicted with early glottic cancer are not a single entity, but a quite heterogeneous group with great complexity and possibility,32 and thus the treatment selection between open surgery and endoscopic approach of this population is intricate. Meticulous selection of the ideal patients who can benefit the most from ELS, and offering rigorous follow-up procedures to detect recurrence in time are recommended.…”

mentioning

confidence: 99%

Age as Indicator in the Selection of Surgery Modalities in Early Glottic Cancer

Wu¹,

You²,

Qiu³

et al. 2021

RMHP

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Purpose Local failure after endoscopic laryngeal surgery (ELS) for early glottic cancer mounts a challenge to researchers to investigate risk factors of recurrence. The present study was therefore designed to explore the prognostic factors in patients who underwent ELS for early glottic cancer. Patients and Methods We reviewed 328 patients with T1-2N0 glottic cancer who were treated with either ELS or open surgery between 2007 and 2018 at our institution. Survival, univariate and multivariate analyses were performed in different groups (ELS vs open surgery; < 65 vs ≥ 65 years). Results Age was discovered to be the independent prognostic factor of DFS for patients treated with ELS (HR = 3.673, p = 0.003), but not for patients who underwent open surgery. Survival analysis performed on young patients (< 65 years) showed that survival outcomes between different surgery modalities were significantly different (ELS vs open surgery: five-year DFS: 72.5 vs 84.7%, p = 0.034). Univariate and multivariate analyses further confirmed the finding, whereas these results did not appear in old patients (≥ 65 years). Conclusion Young patients (< 65 years) treated with ELS had less favorable oncologic outcomes than those treated with open surgery. Young patients (< 65 years) are advised to consider open surgery over ELS.

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T1 Glottic Cancer: Does Anterior Commissure Involvement Worsen Prognosis?

Cited by 10 publications

References 31 publications

Prognostic and Treatment Differences Between T1a and T1b Glottic Cancer

Prognostic and Treatment Differences Between T1a and T1b Glottic Cancer

Scanning Super/Ultrapulsed CO2 Laser Efficacy in Laryngeal Malignant Lesions

Age as Indicator in the Selection of Surgery Modalities in Early Glottic Cancer

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