2012
DOI: 10.1016/j.ejrad.2011.11.019
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T1ρ and T2 mapping of the proximal tibiofibular joint in relation to aging and cartilage degeneration

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Cited by 30 publications
(33 citation statements)
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“…In a study using excised human patella cartilage, Keenan et al [26] stated that T1 values reflect the change in GAG content more sensitively than T2 mapping. Our previous results also indicate that T1 mapping is more sensitive for detecting cartilage degeneration than T2 mapping [11,27]. The reason is that by applying the spin-lock pulse, T1 mapping can probe the interactions of protons between the bound water and the GAG, which is the earliest change in the ECM during cartilage degeneration [3,28,29].…”
Section: Discussionmentioning
confidence: 95%
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“…In a study using excised human patella cartilage, Keenan et al [26] stated that T1 values reflect the change in GAG content more sensitively than T2 mapping. Our previous results also indicate that T1 mapping is more sensitive for detecting cartilage degeneration than T2 mapping [11,27]. The reason is that by applying the spin-lock pulse, T1 mapping can probe the interactions of protons between the bound water and the GAG, which is the earliest change in the ECM during cartilage degeneration [3,28,29].…”
Section: Discussionmentioning
confidence: 95%
“…Even in their study, there are significant differences in age between groups (54.0 ± 10.0 and 32.7 ± 9.0, respectively). Furthermore, Hirose et al [11] reported that T1 and T2 values showed an increase in positive correlation with OA progression by KL grade. However, the patients with severe OA (KL grade 3; 67.1 ± 13.3 years old, KL grade 4; 73.9 ± 5.7 years old) were significantly older than those with normal cartilage (KL grade 0; 21.3 ± 8.3 years old) and those with mild OA (KL grade 1; 23.4 ± 12.1 years old, KL grade 2; 32.3 ± 21.7 years old).…”
Section: Discussionmentioning
confidence: 96%
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