Tablet coating by injection molding technology – Optimization of coating formulation attributes and coating process parameters

Desai, Parind M.; Puri, Vibha; Brancazio, David; Halkude, Bhakti S.; Hartman, Jeremy E.; Wahane, Aniket; Martinez, Alexander R.; Jensen, Keith D.; Harinath, Eranda; Braatz, Richard D.; Chun, Jung-Hoon; Trout, Bernhardt L.

doi:10.1016/j.ejpb.2017.10.006

Cited by 13 publications

(10 citation statements)

References 36 publications

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“…Solvent-free coating includes various technologies such as compression coating, dry powder coating, electrostatic spray powder coating, and photocuring coating [ 10 , 15 , 16 ]. Recently, injection molding coating and hot melt coating have also been proposed as dry coating processes that do not require solvent [ 14 , 17 , 18 , 19 ]. In the injection molding coating process, the upper and lower surfaces of tablets are coated in two steps using a vertical injection molding unit.…”

Section: Film Coating Methodsmentioning

confidence: 99%

“…It is important to choose the right polymer because quality varies depending on workplace humidity and polymer properties. As high temperature (over 80 °C) is used for coating, it is important to examine the surface conditions of coated tablets after cooling [ 14 , 17 ]. Hot-melt coating is also a dry coating method in which a lipid excipient is heated for melting and then sprayed onto the surface of tablets to form a coherent coating layer [ 18 ].…”

Section: Film Coating Methodsmentioning

confidence: 99%

“…To avoid these external factors causing instability of APIs or drug products, film coating can be applied to the surface of core tablets. Hydrophobic materials such as lipids, wax, and triglycerides are often used for sub-coating or outer-coating to protect the core tablet against external environmental factors [ 17 ]. Various water soluble and insoluble polymers, including polysaccharides, polypeptides, and vinyl polymers, are also widely used for film coating to improve drug stability [ 7 ].…”

Section: Pharmaceutical Application Of Film Coatingmentioning

confidence: 99%

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Pharmaceutical Application of Tablet Film Coating

et al. 2020

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Tablet film coating is a common but critical process providing various functionalities to tablets, thereby meeting diverse clinical needs and increasing the value of oral solid dosage forms. Tablet film coating is a technology-driven process and the evolution of coated dosage forms relies on advancements in coating technology, equipment, analytical techniques, and coating materials. Although multiple coating techniques are developed for solvent-based or solvent-free coating processes, each method has advantages and disadvantages that may require continuous technical refinement. In the film coating process, intra- and inter-batch coating uniformity of tablets is critical to ensure the quality of the final product, especially for active film coating containing active pharmaceutical ingredients in the coating layer. In addition to experimental evaluation, computational modeling is also actively pursued to predict the influence of operation parameters on the quality of the final product and optimize process variables of tablet film coating. The concerted efforts of experiments and computational modeling can save time and cost in optimizing the tablet coating process. This review provides a brief overview of tablet film coating technology and modeling approaches with a focus on recent advancements in pharmaceutical applications.

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Section: Film Coating Methodsmentioning

confidence: 99%

Section: Film Coating Methodsmentioning

confidence: 99%

Section: Pharmaceutical Application Of Film Coatingmentioning

confidence: 99%

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Pharmaceutical Application of Tablet Film Coating

et al. 2020

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“…Compression coating is a dry process 24,25,26 . This type of tablet (compression coated tablet) has two parts, internal core and surrounding coat 27,28 . The core is small porous tablet and prepared on one turret.…”

Section: Tablet-in-tablet Technologymentioning

confidence: 99%

A Review of Tablet in Tablet Vitamin D3 Formulation Techniques

Inigo¹,

Ramprasad²,

Senthilkumar³

et al. 2018

AJPHR

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The studies is to review formulated core tablets (tablet in tablet) and difficulty in the formulation and evaluation. Numerous techniques are used overcome the problem of stability. The tablet coating have number of advantages like masking odor, taste, color of the drug, providing physical and chemical protection to drug, Protecting drug from the gastric environment. Most of the tablets are instable in gastro industrial tract. Coated, encapsulation, capsules instructed tablet, gel coated tablet. Vitamin D3 containing cholecalciferol (made from 7-dehydrocholesterol in the skin). Several forms (vitamins) of vitamin D exist. The two major forms are vitamin D2 or ergocalciferol, and vitamin D3 or cholecalciferol; vitamin D without a subscript refers to either D2 or D3 or both. Vitamin D3 contain natural foods like Fatty fish, like tuna, mackerel, and salmon Foods fortified with vitamin D, like some dairy products, orange juice, soy milk, and cereals, Beef liver, Cheese, Egg yolks. Industrial production encovndred several evaluation error like weight variation, hardness, friability, thickness, solubility, disintegration test. Here dissolution test not necessary because vitD3 was a supplementary USP not recognized. Nutrients do not work alone, and when it comes to taking vitamin D, its important that you take any compound and vitamin D together and not JUST vitamin d alone in large doses as this can lead to what people BELIEVE are vitamin d side effects.

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“…The literature offers examples of direct feeding of powder blends for the manufacture of drug dosage forms via injection moulding (Cuff and Raouf, 1999;Eggenreich et al, 2016), including continuous manufacturing processes (Mascia et al, 2013;Melocchi et al, 2015). The technology is also being investigated for tablet coating applications (Desai et al, 2018a(Desai et al, , 2018bPuri et al, 2018).…”

Section: Introductionmentioning

confidence: 99%