Tadalafil in patients on antihypertensive medications: Does safety remain an issue?

Theofilis, Panagiotis; Nakas, Nikos; Kalaitzidis, Rigas

doi:10.1111/jch.14433

Cited by 2 publications

(1 citation statement)

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“…To date, natural bioactive molecules have become crucial resources for the discovery of new medicines and pesticides. − Among them, the molecular skeleton 1,2,3,4-tetrahydro-β-carboline (THBC) is widely present in nature and displays broad-spectrum bioactivities, , thus representing an attractive option for drug development by researchers. For example, several highly effective drugs/pesticides derived from THBC have been developed successfully to treat plants and human diseases, such as reserpine, vincamine, , evodiamine, − yohimbine, rutaecarpine, tadalafil, and chloroinconazide. , Moreover, novel THBC derivatives decorated with the 1,3-diaminopropan-2-ol pattern were first reported by our group as antibacterial agents to manage plant bacterial diseases . However, systematic investigations based on promising THBC derivatives are necessary.…”

Section: Introductionmentioning

confidence: 99%

Discovery and Structural Optimization of 1,2,3,4-Tetrahydro-β-carbolines as Novel Reactive Oxygen Species Inducers for Controlling Intractable Plant Bacterial Diseases

Liu,

Su,

et al. 2023

J. Agric. Food Chem.

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Nowadays, reactive oxygen species (ROS) have been acknowledged as promising bactericidal targets against pesticide-resistant bacteria. Herein, to further excavate more excellent ROS inducers, simple 1,2,3,4-tetrahydro-β-carboline derivatives containing a 3-aminopropanamide moiety were prepared and assessed for their antibacterial potency. Notably, three promising compounds displayed significant antibacterial potency. Compound I 29 exhibits excellent in vitro bioactivity, with an EC50 value of 5.73 μg/mL, and admirable in vivo activities (protective activity of 55.74% and curative activity of 65.50%) toward Xanthomonas oryzae pv. oryzae. Compound I 16 has good activity in vitro, with an EC50 of 3.43 μg/mL, and outstanding bioactivities in vivo (protective activity of 92.50% and curative activity of 59.68%) against Xanthomonas axonopodis pv. citri. Compound I 6 shows excellent in vitro bioactivity (EC50 = 2.86 μg/mL) and significant protective activity (94.02%) for preventing Pseudomonas syringae pv. actinidiae. Antibacterial mechanism investigations indicate that these compounds disrupt the balance of the redox system to kill bacteria. These simple 1,2,3,4-tetrahydro-β-carboline derivatives are promising leads to the discovery of bactericidal agents.

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