Tailored Fringed Platforms Produced by Laser Interference for Aligned Neural Cell Growth

Peláez, R. J.; González‐Mayorga, Ankor; Gutiérrez, Marı́a C.; García-Rama, Concepción; Afonso, Carmen N.; Serrano, María Concepción

doi:10.1002/mabi.201500253

Cited by 5 publications

(5 citation statements)

References 38 publications

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“…Compared to most reported graphene-based patterns on certain substrates via other techniques, − the reported laser-scribed process of 3D graphene-based micropatterns can selectively and precisely tune GO to rGO conversion and pattern GO–rGO–GO structures, which benefit to utilize the different properties (conductivity, hydrophilicity, adsorptivity) of GO and rGO for potential applications in electronics, biomedicine, and energy. The current repurposing laser-scribing approach provides a standard, general, and robust platform for micro/nanofabrication in a time- and cost-effective manner and can be easily extended to produce and pattern various graphene hybrids (such as polymer/graphene, metal nanostructures/graphene hybrids), other emerging nongraphene 2D materials, and their hybrids, which will fulfill the requirements to amend capability of graphene devices and fit them into more applications in various fields.…”

Section: Discussionmentioning

confidence: 99%

“…Some interesting attempts have been made to utilize graphene-based micropatterns (such as fluorinated , graphene lines, , rGO lines, , GO grooves, lines, and grids) with dimensions ranging from several tens to several hundred micrometers fabricated via conventional lithographic and laser irradiation techniques as a promising platform and cell-guiding physical cues for controlling cell adhesion, alignment, ,, differentiation, and gene delivery, which have great potential in biomedical applications (such as tissue engineering) . Regrettably, these techniques are too complex to produce low-cost, scalable graphene-based patterns, which greatly impedes the translation of interesting findings relating control of cell behavior into practical applications.…”

Section: Introductionmentioning

confidence: 99%

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Highly Tunable and Scalable Fabrication of 3D Flexible Graphene Micropatterns for Directing Cell Alignment

Zhang

Zhu

et al. 2018

ACS Appl. Mater. Interfaces

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Patterning graphene allows to precisely tune its properties to manufacture flexible functional materials or miniaturized devices for electronic and biomedical applications. However, conventional lithographic techniques are cumbersome for scalable production of time- and cost-effective graphene patterns, thus greatly impeding their practical applications. Here, we present a simple scalable fabrication of wafer-scale three-dimensional (3D) graphene micropatterns by direct laser tuning graphene oxide reduction and expansion using a LightScribe DVD writer. This one-step laser-scribing process can produce custom-made 3D graphene patterns on the surface of a disk with dimensions ranging from microscale up to decimeter scale in about 20 min. Through control over laser-scribing parameters, the resulting various 3D graphene patterns are exploited as scaffolds for controlling cell alignment. The 3D graphene patterns demonstrate their potential to biomedical applications, beyond the fields of electronics and photonics, which will allow to incorporate flexible graphene patterns for 3D cell or tissue culture to promote tissue engineering and drug testing applications.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Highly Tunable and Scalable Fabrication of 3D Flexible Graphene Micropatterns for Directing Cell Alignment

Zhang

Zhu

et al. 2018

ACS Appl. Mater. Interfaces

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“…For instance, previous reports have shown that grid micropatterned ECM proteins could promote neuronal differentiation of NSCs, while square pattern promoted the formation of glial cells . Graphene‐patterned substrates have been developed to enhance cell adhesion, neurite outgrowth, alignment, and neural differentiation …”

Section: Graphene‐based Scaffolds For Neurogenesis and Myogenesismentioning

confidence: 99%

“…The interesting preferential cell adhesion on graphene stripes might result from the better deposition of PDL precoating, as atomic force microscope characterization clearly indicated a thicker PDL layer on graphene coated region than bare glass surface. Similarly, Pelaez et al used a laser interferometry method to fabricate PDL coated rGO substrates with fringed patterns (a period of 9.4 µm), which promoted the neurite alignment of rat embryonic neural progenitor cells (ENPCs) compared to nonpatterned graphene surface. Recently, a one‐step strategy was developed by Lee et al to prepare patterned graphene based films via infrared based photothermal reduction on GO films, which contain both rGO regions with high conductivity and unique topographical roughness and also GO regions for potential functionalization .…”

Section: Graphene‐based Scaffolds For Neurogenesis and Myogenesismentioning

confidence: 99%

Electroactive Scaffolds for Neurogenesis and Myogenesis: Graphene‐Based Nanomaterials

Zhang

Klausen

Chen

et al. 2018

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One of the major issues in tissue engineering is constructing a functional scaffold to support cell growth and also provide proper synergistic guidance cues. Graphene‐based nanomaterials have emerged as biocompatible and electroactive scaffolds for neurogenesis and myogenesis, due to their excellent tunable chemical, physical, and mechanical properties. This review first assesses the recent investigations focusing on the fabrication and applications of graphene‐based nanomaterials for neurogenesis and myogenesis, in the form of either 2D films, 3D scaffolds, or composite architectures. Besides, because of their outstanding electrical properties, graphene family materials are particularly suitable for designing electroactive scaffolds that could provide proper electrical stimulation (i.e., electrical or photo stimuli) to promote the regeneration of excitable neurons and muscle cells. Therefore, the effects and mechanism of electrical and/or photo stimulations on neurogenesis and myogenesis are followed. Furthermore, studies on their biocompatibilities and toxicities especially to neural and muscle cells are evaluated. Finally, the future challenges and perspectives in facilitating the development of clinical translation of graphene‐family nanomaterials in treating neurodegenerative and muscle diseases are discussed.

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“…Optical fabrication of grid structures for growing linear neurons has been demonstrated via laser ablation in graphene [ 182 ] and laser interference reduction of GO. [ 183 ] Figure 7d shows a schematic description of this process. Single layer graphene (SLG) on glass is etched by a pulsed laser to create graphene strips (left).…”

Section: Applications Of Optically Modified 2d Materialsmentioning

confidence: 99%

Optical Modification of 2D Materials: Methods and Applications

2022

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on the same chip, which is promising for integrated electronics or photonics applications, [7] such as lasers, [8][9][10] optical modulators, [11] and photodetectors. [12] Indeed, 2D materials are an excellent candidate for postsilicone electronics due to their unique properties, versatile scaling of channel length, reduced device dimensionalities, and the possibility of creating circuits nearly at the atomic level. [13] Currently, some of the biggest challenges for 2D material synthesis include the lack of large-scale manufacturing and the necessity of harsh or arduous microand nanofabrication methods. Typical fabrication methods are based on chemical vapor deposition (CVD) and mechanical exfoliation from bulk crystals. The former involves a process that results in layers with relatively high concentrations of atomic impurities, [14] and the latter is limited in producing large area flakes. [14] Further fabrication steps for the incorporation of 2D materials into integrated devices typically require processes like electron-beam lithography and reactive ion etching, [15] both of which can be harmful to flakes that are atomically thin.All-optical processing of 2D materials has been demonstrated to overcome limitations of the conventional synthesis methods. It is time-and cost-effective, and it is also a promising fabrication alternative over CVD and mechanical exfoliation. Optical modification processes offer selectivity, locality, directionality, tunability, less harmful conditions, and on-demand functionalities, such as optical doping, [16][17][18][19] oxidation, [20][21][22][23] optical thinning, [24][25][26][27][28] and phase change. [29][30][31][32] Additionally, almost all of the optical modification and fabrication methods can be used for laser-direct writing (LDW) of patterns and structures at the microscale. [33][34][35][36] The high precision of LDW is particularly advantageous in the evolving world of nanofabrication. Lasers allow local modification of 2D material electronic bandgap, [37] thickness, [25] strain, [33,[38][39][40] and chemical composition, [19,41,42] even beyond the diffraction limit. [33] The created structures and patterns can often be directly used for applications in sensors, [22] energyprocessing devices, [43] and holography [44] (Figure 1). All the major demonstrations using LDW on 2D materials are listed in Table 1. Here, we review the optically assisted synthesis and fabrication methods of 2D materials, and their state-of-theart applications, providing detailed descriptions and features of optically engineered devices using 2D materials. We have straightforwardly introduced light-matter interactions and 2D-material-light interactions, and we also present our perspectives on this emerging field.2D materials are under extensive research due to their remarkable properties suitable for various optoelectronic, photonic, and biological applications, yet their conventional fabrication methods are typically harsh and costineffective. Optical modification is demonstrated as an effective an...

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Tailored Fringed Platforms Produced by Laser Interference for Aligned Neural Cell Growth

Cited by 5 publications

References 38 publications

Highly Tunable and Scalable Fabrication of 3D Flexible Graphene Micropatterns for Directing Cell Alignment

Highly Tunable and Scalable Fabrication of 3D Flexible Graphene Micropatterns for Directing Cell Alignment

Electroactive Scaffolds for Neurogenesis and Myogenesis: Graphene‐Based Nanomaterials

Optical Modification of 2D Materials: Methods and Applications

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