Tailored Synthesis of Octopus‐type Janus Nanoparticles for Synergistic Actively‐Targeted and Chemo‐Photothermal Therapy

Abstract

A facile, reproducible, and scalable method was explored to construct uniform Au@poly(acrylic acid) (PAA) Janus nanoparticles (JNPs). The as-prepared JNPs were used as templates to preferentially grow a mesoporous silica (mSiO2 ) shell and Au branches separately modified with methoxy-poly(ethylene glycol)-thiol (PEG) to improve their stability, and lactobionic acid (LA) for tumor-specific targeting. The obtained octopus-type PEG-Au-PAA/mSiO2 -LA Janus NPs (PEG-OJNP-LA) possess pH and NIR dual-responsive release properties. Moreover, DOX-loaded PEG-OJNP-LA, upon 808 nm NIR light irradiation, exhibit obviously higher toxicity at the cellular and animal levels compared with chemotherapy or photothermal therapy alone, indicating the PEG-OJNP-LA could be utilized as a multifunctional nanoplatform for in vitro and in vivo actively-targeted and chemo-photothermal cancer therapy.

Molecular Targeting‐Mediated Mild‐Temperature Photothermal Therapy with a Smart Albumin‐Based Nanodrug

“…Besides, the calculated synergistic index (SI) for the combined HSA/dc‐IR825/GA and NIR treatment was ≈1.12 (>1), further verifying the synergistic effect between GA and the PTT effect of dc‐IR825 in HSA/dc‐IR825. On the one hand, PTT can enhance the chemotherapeutic efficacy of the nanoagents through light‐induced drug release or cytoplasmic drug translocation 12b,22. Similarly, in our case, the NIR laser irradiation triggered the escape of GA in HSA/dc‐IR825/GA NPs from mitochondria to the cytosol, which would also enhance the chemotherapeutic efficacy of GA. On the other hand, the released GA molecules further blocked the hyperthermia‐induced overexpression of HSP90 and reduced the thermoresistance of tumor cells, which would significantly enhance the photothermal therapeutic efficiency of the nanoagents at a mild temperature.…”

Designed Synthesis of Lipid‐Coated Polyacrylic Acid/Calcium Phosphate Nanoparticles as Dual pH‐Responsive Drug‐Delivery Vehicles for Cancer Chemotherapy

“…Fourier‐transform infrared (FTIR) spectra were used to characterize the PAA/CaP NPs and PAA/CaP@SLB NPs (Figure B). The characteristic peaks located at 1558 and 1414 cm −1 can be attributed to the carbonyl (C=O) group, which originates from the carboxylic acid of PAA . The absorption peaks at 551 and 1062 cm −1 are the characteristic peaks of PO 4 3− .…”

“…Thec haracteristicp eaks located at 1558 and 1414 cm À1 can be attributed to the carbonyl (C=O) group, which originates from the carboxylic acid of PAA. [29,39] The absorption peaks at 551 and 1062 cm À1 are the characteristic peaks of PO 4 3À . [40] Also, compared with PAA/CaP NPs, there was an absorption peak at 1740cm À1 due to the C=Os tretching vibration of the lipid chain, which demonstrated the presence of al ipid bilayer on PAA/CaP NPs.…”

Plasmonic Gold Nanovesicles for Biomedical Applications

“…Janus NPs are a special class of anisotropic NPs in which two halves have distinct physicochemical properties . Song et al prepared a double‐layered (DL) plasmonic–magnetic vesicle with Janus GN‐Fe 3 O 4 as the core .…”