2011
DOI: 10.1002/app.35336
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Tailoring the surface architecture of poly(3‐hydroxybutyrate‐co‐4‐hydroxybutyrate) scaffolds

Abstract: This study was designed to determine whether the surface modifications of the various poly (3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] copolymer scaffolds fabricated would enhance mouse fibroblast cells (L929) attachment and proliferation. The P(3HB-co-4HB) copolymer with a wide range of 4HB monomer composition (16-91 mol %) was synthesized by a local isolate Cupriavidus sp. USMAA1020 by employing the modified two-stage cultivation and by varying the concentrations of 4HB precursors, namely c-bu… Show more

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Cited by 14 publications
(15 citation statements)
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“…Poly(3‐hydroxybutyrate‐ co ‐4‐hydroxybutyrate) [P(3HB‐ co ‐4HB)] is one of the PHAs that gained attention as a promising biomaterial especially in the medical and pharmaceutical application. P(3HB‐ co ‐4HB) has gained interest as cardiovascular patches, drug delivery and tissue engineering application . The incorporation of 4HB monomers into the P(3HB) improves the material application potentials as the copolymer showed a wide range of physical properties from crystalline to rubber‐like material .…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Poly(3‐hydroxybutyrate‐ co ‐4‐hydroxybutyrate) [P(3HB‐ co ‐4HB)] is one of the PHAs that gained attention as a promising biomaterial especially in the medical and pharmaceutical application. P(3HB‐ co ‐4HB) has gained interest as cardiovascular patches, drug delivery and tissue engineering application . The incorporation of 4HB monomers into the P(3HB) improves the material application potentials as the copolymer showed a wide range of physical properties from crystalline to rubber‐like material .…”
Section: Introductionmentioning
confidence: 99%
“…P(3HB-co-4HB) has gained interest as cardiovascular patches, drug delivery and tissue engineering application. 5…”
Section: Introductionmentioning
confidence: 99%
“…Tensile strength, Young's modulus and elongation at break were deduced from the stress/strain curves. The average value of five replicates was taken for each sample …”
Section: Methodsmentioning
confidence: 99%
“…The perspective area of PHB application is in development of implanted medical devices as biodegradable screws and plates for cartilage and bone, biodegradable membranes for periodontal treatment, biodegradable surgical sutures for dental, orthopaedic, cranio‐maxillofacial, hernioplastic, and skin surgery (Figure ). The PHB offers great potential in modern pharmacology for creating novel systems for sustained delivery of antiproliferative and anti‐inflammatory drugs in form of PHB films . The release of drugs occurs by methods, diffusion, and degradation, operating simultaneously.…”
Section: Synthetic Plasticsmentioning
confidence: 99%
“…The PHB offers great potential in modern pharmacology for creating novel systems for sustained delivery of antiproliferative and anti-inflammatory drugs in form of PHB films. 58 The release of drugs occurs by methods, diffusion, and degradation, operating simultaneously. The rate of the release of a drug depends on its nature, the thickness of the PHB films containing the drug, the weight ratio drug and polymer, and the molecular weight of PHB.…”
Section: Applications Of Phbmentioning
confidence: 99%