Takayasu arteritis: A distinct syndrome of large vessel vasculitis: A view point by late Professor Paul Bacon

Misra, Ramnath

doi:10.1111/1756-185x.13383

Cited by 5 publications

(3 citation statements)

References 44 publications

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“…SLE is a prototypical autoimmune disease caused by the over-activation and proliferation of B cells and is characterised by the production of numerous autoantibodies and increased serum IgG levels (22). However, thus far, ideal autoantibodies for identifying TAK have not been identified, and the fluctuation of Ig levels in TAK has been rarely studied (23). Following stimulation by specific immunogens, B cells can terminally differentiate into plasma cells, which produce Ig or antibodies and participate in humoral immunity (24).…”

Section: Discussionmentioning

confidence: 99%

Characteristics of B cells and immunoglobulin profile in Takayasu's arteritis

et al. 2022

Clinical and Experimental Rheumatology

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ObjectiveDisorders of humoral immunity in Takayasu's arteritis (TAK) have not been well explored. This study describes the characteristics of B cells and immunoglobulin (Ig) profile in patients with TAK. Methods Peripheral B cell populations assessed using flow cytometry and serum Ig levels assessed using a biochemical analyserin 98 newly diagnosed patients with TAK were analysed and compared with those of 31 patients with systemic lupus erythematosus (SLE) and 60 healthy controls (HCs). CD19 + B cell and IgG infiltration to the aortic tissue was evaluated by immunohistochemical staining. ResultsThe proportion of peripheral CD3 -CD19 + B cells and levels of serum IgG in TAK were lower than those in SLE, but higher than those in HCs. CD3 -CD19 + B cell counts were higher in TAK than in HCs. Serum IgG and IgG1 levels were higher in active TAK than in non-active TAK. In TAK, positive correlations of serum IgG levels with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, Kerr score, and Indian Takayasu Clinical Activity Score (ITAS2010, ITAS-A) were observed before immunotherapy. After 6 months of immunotherapy, serum Ig levels significantly decreased. Positive correlations between the changes in IgG levels and values of ESR, CRP, Kerr score, and ITAS-A were detected. Immunohistochemical staining confirmed CD19 + B cell and IgG infiltration to the aortic wall in patients with TAK. ConclusionEnhanced B cells might contribute to the pathogenesis of TAK, and serum IgG levels could serve as a simple, useful biomarker to assess disease activity and monitor treatment response in TAK.

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Section: Discussionmentioning

confidence: 99%

Characteristics of B cells and immunoglobulin profile in Takayasu's arteritis

et al. 2022

Clinical and Experimental Rheumatology

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“… [2] Clinical features varies according to the location and severity of the involved arteries, and Patients with characteristic appearances can be diagnosed by the above clinical features. However, most patients with TAK show hidden subacute clinical features, mainly early non-specific signs and systemic symptoms, which are similar to those of other diseases, leading to a delay in early diagnosis and irreversible vascular damage by the time of diagnosis [ 3 , 4 ]. This makes early diagnosis and timely treatment of TAK challenging.…”

Section: Introductionmentioning

confidence: 99%

18F-FDG PET/CT in the diagnosis of Takayasu arteritis: A case report

Chen

Huang

2022

Radiology Case Reports

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The early clinical symptoms of Takayasu arteritis (TAK) are nonspecific and often lead to misdiagnosis or delay in diagnosis. And by the time morphological changes are observed on the images, the disease is in an advanced stage and irreversible vascular injuries has occurred. Therefore, early correct diagnosis and timely systemic anti-inflammatory treatment can effectively improve the clinical situation. Conventional imaging provides only changes in vascular structure and provides little information on inflammatory activity. Here we report the PET/CT imaging presentation of 18F-deoxyglucose ( 18 F-FDG) in a patient with TAK, a 58-year-old patient with known TAK whose disease clustered many non-specific features, and highlight the value of PET/CT in the diagnosis and management of patients with early or atypical clinical presentation of TAK.

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“…Takayasu arteritis (TA) is a large vessel vasculitis predominantly found in Asian populations [1]. Recently various treatment options have come up, including multiple biologicals [2].…”

Section: Introductionmentioning

confidence: 99%

Poor obstetric outcomes in Indian women with Takayasu arteritis

et al. 2020

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Introduction: Takayasu's arteritis (TA) affects young women in the childbearing age group. We studied obstetric outcomes in these patients before and after disease onset. Methods: Women aged more than 18 years with Takayasu's arteritis (ACR 1990 criteria) were included. Demographic data, clinical features, disease activity using Indian Takayasu Arteritis clinical score (ITAS), Disease Extent Index for TA (DEI.TaK) and damage assessment using TA Damage score (TA), history of conception and maternal and fetal outcomes were recorded from hospital records and telephonic interview. Results are in median and IQR. Results: Of the 64 women interviewed, aged 29 (24-38) years and disease duration 5 (4-10) years, 74 and 38 pregnancies had occurred before and after disease diagnosis in 29 and 20 women respectively. In eight, the diagnosis was made during pregnancy. Age at disease onset was 22 (18-30) years. Type 5 disease was the most common (n = 32, 59.3%), and an equal number of patients had Ishikawa's class I and II disease (n = 26, 40.6%). Median ITAS (n = 44) was 13 (7-16), DEI.Tak 12.5 (9-16.75) and TADS 8 (6.5-10). Twenty-five patients wanted to get pregnant, of which 8 (32%) did not do so because of their disease. Fifteen were unmarried of whom 6 did not marry due to disease. Obstetric outcomes were poorer in pregnancies that occurred after the onset of disease as compared with those before it (RR = 1.5, p = 0.01). Pregnancies after the onset of TA carried a very high risk of maternal [RR3.9 (1.8-8.5), P < 0.001] as well as fetal complications [RR = 2.0 (1.2-3.4), p = 0.001]. Hypertension was the most common maternal complication and occurred most often in the last trimester. The baby weight at birth was lower in pregnancies after disease (2.3 vs. 3.0, p = 0.01). Wong's score greater than or equal to 4 predicted lower birth weight (p = 0.04). ITAS, ITAS-A, DEI. Tak and TADS could not predict obstetric outcomes, and ITAS score exhibited moderate correlation with DEI. Tak (r = 0.78) and TADS (r = 0.58). Conclusion: Women with TA suffer from extremely high risk of poor maternal and foetal outcomes. Wong's scoring can be useful to predict birth weight.

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Takayasu arteritis: A distinct syndrome of large vessel vasculitis: A view point by late Professor Paul Bacon

Cited by 5 publications

References 44 publications

Characteristics of B cells and immunoglobulin profile in Takayasu's arteritis

Characteristics of B cells and immunoglobulin profile in Takayasu's arteritis

18F-FDG PET/CT in the diagnosis of Takayasu arteritis: A case report

Poor obstetric outcomes in Indian women with Takayasu arteritis

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