Taking a hard line with biotemplating: cobalt-doped magnetite magnetic nanoparticle arrays

Bird, Scott M.; Galloway, Johanna M.; Rawlings, Andrea E.; Bramble, Jonathan P.; Staniland, Sarah S.

doi:10.1039/c5nr00651a

Cited by 33 publications

(36 citation statements)

References 68 publications

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“…Such coatings allow a facile functionalization via amine coupling and increase hydrophilicity . Similar structures may be made by templating or wet phase synthesis methods, even though the previously described advantages of the single step FSP process get even more pronounced for the production of such complex materials.…”

Section: Introductionsupporting

confidence: 90%

Silica‐Coated Nonstoichiometric Nano Zn‐Ferrites for Magnetic Resonance Imaging and Hyperthermia Treatment

Starsich

Sotiriou

Wurnig

et al. 2016

Adv Healthcare Materials

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Large-scale and reproducible synthesis of nanomaterials is highly sought out for successful translation into clinics. Flame aerosol technology with its proven capacity to manufacture high purity materials (e.g., light guides) up to kg h −1 is explored here for the preparation of highly magnetic, nonstoichiometric Zn-ferrite (Zn 0.4 Fe 2.6 O 4 ) nanoparticles coated in situ with a nanothin SiO 2 layer. The focus is on their suitability as magnetic multifunctional theranostic agents analyzing their T2 contrast enhancing capability for magnetic resonance imaging (MRI) and their magnetic hyperthermia performance. The primary particle size is closely controlled from 5 to 35 nm evaluating its impact on magnetic properties, MRI relaxivity, and magnetic heating performance. Most importantly, the addition of Zn in the flame precursor solution facilitates the growth of spinel Zn-ferrite crystals that exhibit superior magnetic properties over iron oxides typically made in flames. These properties result in strong MRI T2 contrast agents as shown on a 4.7 T small animal MRI scanner and lead to a more efficient heating with alternating magnetic fields. Also, by injecting Zn 0.4 Fe 2.6 O 4 nanoparticle suspensions into pork tissue, MR-images are acquired at clinically relevant concentrations. Furthermore, the nanothin SiO 2 shell facilitates functionalization with polymers, which improves the biocompatibility of the theranostic system.

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Section: Introductionsupporting

confidence: 90%

Silica‐Coated Nonstoichiometric Nano Zn‐Ferrites for Magnetic Resonance Imaging and Hyperthermia Treatment

Starsich

Sotiriou

Wurnig

et al. 2016

Adv Healthcare Materials

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“…However, we were able to use a surface based nanoplasmonic sensing experiment (using the Xnano (Insplorion) [32]) to probe Mms6MM and compare it to native Mms6 in terms of their interaction with iron ions and their ability to promote/ impede the precipitation of iron-oxide in vitro. Previous research has demonstrated how Mms6 is able to promote the formation of magnetite when assembled on a gold surface as this surface assembly better mimics the native environment on the membrane within the magnetosome [25,33,34]. The absence of the SUMO tag thus ensures any self-assembly is not restricted.…”

Section: Nanoplasmonic Surface Investigation Of Mms6 Triple Mutantmentioning

confidence: 99%

Investigating the ferric ion binding site of magnetite biomineralisation protein Mms6

et al. 2020

Self Cite

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The biomineralization protein Mms6 has been shown to be a major player in the formation of magnetic nanoparticles both within the magnetosomes of magnetotactic bacteria and as an additive in synthetic magnetite precipitation assays. Previous studies have highlighted the ferric iron binding capability of the protein and this activity is thought to be crucial to its mineralizing properties. To understand how this protein binds ferric ions we have prepared a series of single amino acid substitutions within the C-terminal binding region of Mms6 and have used a ferric binding assay to probe the binding site at the level of individual residues which has pinpointed the key residues of E44, E50 and R55 involved in Mms6 ferric binding. No aspartic residues bound ferric ions. A nanoplasmonic sensing experiment was used to investigate the unstable EER44, 50,55AAA triple mutant in comparison to native Mms6. This suggests a difference in interaction with iron ions between the two and potential changes to the surface precipitation of iron oxide when the pH is increased. All-atom simulations suggest that disruptive mutations do not fundamentally alter the conformational preferences of the ferric binding region. Instead, disruption of these residues appears to impede a sequence-specific motif in the C-terminus critical to ferric ion binding.

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“…Recently, they have also performed a study with some variations of previous approach to pattern engineered Mms6 proteins containing an N-terminal cysteine capable of binding directly onto the surface and biotemplating magnetite nanocrystals. [297] This surface based biomineralisation experiment therefore offered a unique in vitro method of studying Mms6 in an environment similar to the native state, anchored in the magnetosome membrane. In their very recent study, they have used a similar biomimetic system to investigate the differences between the Mms6 C-terminal peptide and the intact Mms6 protein in magnetite synthesis.…”

Section: Protein Mediated Synthesis Of Magnetite Nanoparticlesmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

204

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Taking a hard line with biotemplating: cobalt-doped magnetite magnetic nanoparticle arrays

Abstract: A cysteine-mutated biomineralisation protein (Mms6) patterned onto gold biotemplates magnetic nanoparticle arrays of magnetite and higher coercivity cobalt-doped magnetite. This demonstrates an adaptable, green approach for the future of nanofabrication.

Cited by 33 publications

References 68 publications

Silica‐Coated Nonstoichiometric Nano Zn‐Ferrites for Magnetic Resonance Imaging and Hyperthermia Treatment

Silica‐Coated Nonstoichiometric Nano Zn‐Ferrites for Magnetic Resonance Imaging and Hyperthermia Treatment

Investigating the ferric ion binding site of magnetite biomineralisation protein Mms6

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

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