Tako–Tsubo Syndrome in a psychiatric woman with bipolar disorder

Tommasi, Elisabetta De; Ramunni, Giovanni; Boscia, Filippo; Brunetti, Natale Daniele

doi:10.1016/j.ijcard.2011.09.053

Cited by 5 publications

(1 citation statement)

References 9 publications

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“…5 Previous studies have reported cases of TTS related to acute manic attacks [6][7][8] or to an underlying bipolar disorder. 9,10 The exact aetiology of TTS is still unknown, but one hypothesis is that psychiatric illness and chronic stress could activate the hypothalamic-pituitary-adrenal (HPA) axis, increasing release of catecholamines, 11 and subsequently causing TTS. 12 Indeed, bipolar disorders are known to lead to increased activation of the catecholamines, especially in manic state.…”

Section: Discussionmentioning

confidence: 99%

Takotsubo Syndrome Associated with a New Onset Manic Episode: A case report

Shen

Liu

2021

J Int Med Res

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Takotsubo syndrome is a condition that mimics acute coronary syndrome. The exact pathogenesis of the condition is unclear but it tends to occur more frequently in elderly women and a large proportion of cases have acute, former, or chronic neurologic or psychiatric disorders. Here we describe a 55-year-old female patient, who was brought to the emergency department presenting with a new-onset manic episode characterized by grandiosity, distractibility, decreased need for sleep, and increased goal-directed behaviours. She experienced chest pain approximately two days later, and non-ST elevation myocardial infarction was observed. The emergent coronary angiogram showed patent coronary arteries, and a diagnosis of Takotsubo syndrome was made. We suggest clinical multidisciplinary vigilance for somatic complaints, especially cardiac ones, in people with psychiatric disorders in order to make timely therapeutic interventions.

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Section: Discussionmentioning

confidence: 99%

Takotsubo Syndrome Associated with a New Onset Manic Episode: A case report

Shen

Liu

2021

J Int Med Res

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Biventricular thrombosis in biventricular stress(takotsubo)-cardiomyopathy

Ruggiero

Musci

Tota

et al. 2017

J Thromb Thrombolysis

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Endo-ventricular thrombosis represents a possible clinical complication of stress(takotsubo)-cardiomyopathy (SC). Depressed ventricular systolic ventricular function, localized left ventricular (LV) dyskinesis, but also an increased pro-thrombotic state induced by catecholamine surge may facilitate the occurrence of endovascular thrombosis in SC. SC, however, may also present as right ventricular (RV) dysfunction or even as biventricular ballooning. Ventricular thrombosis may therefore theoretically occur in either ventricles or both. We report the case of an 88-year old woman, with vascular dementia and depression, admitted for abdominal pain, diarrhea, and rectal bleeding. Unexpectedly, electrocardiogram showed induced QT-prolongation with diffuse negative T-waves, while echocardiogram severe LV dysfunction (ejection fraction 35%), but also RV dysfunction and biventricular thrombosis. The diagnosis was therefore biventricular SC complicated by biventricular thrombosis; LV recovered after 10 days. When SC presents with a biventricular involvement, a careful assessment of either ventricular cavities should be therefore recommended to exclude the presence of (bi)ventricular thrombosis. It remains unresolved whether biventricular SC may represent a condition at higher risk of ventricular thrombosis.

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