Tannic acid inhibited norovirus binding to HBGA receptors, a study of 50 Chinese medicinal herbs

Zhang, Xu-Fu; Dai, Ying-Chun; Zhong, Weiming; Tan, Ming; Lv, Zhi-Ping; Zhou, Yingchun; Jiang, Xi

doi:10.1016/j.bmc.2011.11.040

Cited by 58 publications

(52 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We previously reported that E. bicyclis methanolic extract exhibit antiviral activity against FCV (Choi et al 2014). However, as described above, FCV may not be the most suitable surrogate for evaluating the efficacy of disinfectants against human norovirus (Cannon et al 2006, Zhang et al 2012. Therefore, the antiviral activity of E. bicyclis extracts against MNV as a norovirus surrogate was evaluated.…”

Section: Resultsmentioning

confidence: 99%

“…However, there are limitations in the progress of this study, due to inefficient cell culture amplification process for norovirus (Guix et al 2007, Lay et al 2010. Recent studies revealed that the structure and genetic relatedness of murine norovirus (MNV) to human norovirus makes this virus a promising and relevant surrogate for studying the environmental survivability of human norovirus (Cannon et al 2006, Zhang et al 2012.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In vitro antiviral activity of dieckol and phlorofucofuroeckol-A isolated from edible brown alga Eisenia bicyclis against murine norovirus

Eom¹,

Moon²,

Lee³

et al. 2015

ALGAE

View full text Add to dashboard Cite

This research was conducted to develop effective and safe marine-derived antiviral compounds against norovirus. The ethyl acetate (EtOAc)-extract from Eisenia bicyclis exhibited strong antiviral activity against murine norovirus (MNV) as a norovirus surrogate. Among the phlorotannins from E. bicyclis, dieckol (DE) and phlorofucofuroeckol-A (PFF) were known to possess the strongest antibacterial activity. In this study, DE and PFF were evaluated for antiviral activity against MNV. DE and PFF exhibited strong anti-MNV activity with 50% effective concentration (EC 50 ) of 0.9 μM. However, PFF exhibited more effective antiviral activity against MNV with higher selective index (668.87) than that of DE (550.60), due to its lower cell toxicity against RAW 264.7. This is the first report on the anti-MNV activity of phlorotannins from seaweed. The results obtained in this study suggest that the phlorotannins could be used as a potential source of natural antiviral agents.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro antiviral activity of dieckol and phlorofucofuroeckol-A isolated from edible brown alga Eisenia bicyclis against murine norovirus

Eom¹,

Moon²,

Lee³

et al. 2015

ALGAE

View full text Add to dashboard Cite

show abstract

“…TA has a high spectrum of bioactivities such as antioxidant, 37 antibacterial, 38 anticarcinogenic, 39 antimutagenic 40 and antiviral 41 properties. Through electrostatic or hydrogen bonding interactions, TA has been assembled via the LbL assembly method with poly(dimethyldiallylamide), 42 poly(allylamine), [42][43][44] poly(Nvinylcaprolactam), 45,46 poly(N-vinylpyrrolidone), [45][46][47] poly(ethylene oxide), 45 poly(N-isopropylacrylamide), 45,46 poly(2-n-propyl-2-oxazoline), 48 Fe III ions 49,50 and proteins 51 to form thin films.…”

Section: Ta Capsulesmentioning

confidence: 99%

Phenolic film engineering for template-mediated microcapsule preparation

Ejima

Richardson

Caruso

2014

Polym J

View full text Add to dashboard Cite

Microcapsules are of scientific and technological interest because of their ability to encapsulate cargo inside their hollow interiors, thereby separating and protecting the cargo from the external environment. Both template-free and -mediated strategies have been exploited to prepare microcapsules. For the latter strategy, coating sacrificial particulate templates with robust films is a key step towards obtaining mechanically-stable hollow architectures following template removal. In this review, we focus on phenolic-based film engineering techniques utilizing dopamine (DA) and tannic acid (TA), which have recently emerged as new platforms for template-mediated capsule preparation. The first part of the review describes the selfpolymerization of DA, which preferentially occurs at interfaces. The second part of the review describes TA capsules. Particular emphasis is placed on the coordination-triggered rapid deposition of TA on different substrates. These examples highlight the versatility and simplicity of phenolic film engineering strategies for microcapsule preparation. Phenolics are abundant bio-based materials, and thus form an attractive field of research for the future development of microcapsules.

show abstract

“…Previous studies showed that TA exerts various biological effects including anti-inflammatory [26] , antiviral [27] , antibacterial [28] and anticancer [29] . The latter can be mediated by inducing apoptosis [30] .…”

Section: Research Highlightmentioning

confidence: 99%

Targeting CD38 in the tumor microenvironment; a novel approach to treat glioma

Blacher¹,

Levy²,

Baruch³

et al. 2015

Can Cell Microenviron

View full text Add to dashboard Cite

Glioblastoma multiforme (GBM) is one of the most lethal human cancers, accounting for about 15% of all primary brain tumors in adults. Tumor-associated microglia/macrophages (TMMs) are a major constituent of the tumor mass and the tumor microenvironment where they support tumor progression. We previously demonstrated that the NAD + utilizing ectoenzyme CD38 regulates microglia activation and that loss of CD38 inhibits glioma progression and extends the survival of glioma-bearing mice. These results indicated that targeting CD38 in the tumor microenvironment may serve as a novel therapeutic approach to treat glioma. To test this hypothesis, we identified small molecules that inhibit CD38 enzymatic activity (NAD + glycohydrolase): the natural anthranoid rhein, its water-soluble tri-potassium salt (K-rhein), and the polyphenol tannic acid (TA). Microglial properties regulated by CD38 (e.g., NO secretion and LPS/IFN activation induced cell death) were inhibited in primary microglia treated with rhein in a CD38-dependent manner. Furthermore, wild-type mice intracranially injected with GL261 mouse glioma cells and intranasally treated with K-rhein or TA, exhibited significant reduction in tumor volume and prolonged life-span compared to vehicle treated mice. On the other hand, these inhibitors had only a modest effect on tumor-bearing Cd38 / mice. Taken together, our results demonstrate that small molecule CD38 inhibitors such as K-rhein and TA can target CD38 in the tumor microenvironment and offer a novel and useful strategy for glioma treatment.

show abstract

Tannic acid inhibited norovirus binding to HBGA receptors, a study of 50 Chinese medicinal herbs

Cited by 58 publications

References 44 publications

In vitro antiviral activity of dieckol and phlorofucofuroeckol-A isolated from edible brown alga Eisenia bicyclis against murine norovirus

In vitro antiviral activity of dieckol and phlorofucofuroeckol-A isolated from edible brown alga Eisenia bicyclis against murine norovirus

Phenolic film engineering for template-mediated microcapsule preparation

Targeting CD38 in the tumor microenvironment; a novel approach to treat glioma

Contact Info

Product

Resources

About