Tannins from the leaves of Punica granatum

Hussein, Sahar; Barakat, Heba H.; Merfort, Irmgard; Nawwar, Mahmoud A.M.

doi:10.1016/s0031-9422(96)00888-6

Cited by 86 publications

(44 citation statements)

References 7 publications

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“…The n-BuOH extract provided two hydrolyzable tannins, which were identified as pedunculagin (1) (Yoshida et al, 1984) and tellimagrandin Ⅰ (2) (Yoshida et al, 1984). The EtOAc extract yielded tellimagrandin Ⅰ (2), Ⅱ (3) (Wilkins and Bohm, 1976), heterophylliin A (4) (Yoshida et al, 1991) (Yoshida et al, 1992), 1,2,4-tri-O-galloyl-β-D-glucose (6) (Hussein et al, 1997), 1,2,3,6-tetra-O-galloyl-β-D-glucose (7) (Haddock et al, 1982), 1,2,4,6-tetra-O-galloyl-β-D-glucose (8) (Haddock et al, 1982), 1,2,3,4,6-penta-O-galloyl-β-D-glucose (9) (Haddock et al, 1982), ellagic acid (10) and gallic acid (11). Compound 6 was identified by its corresponding published spectroscopic data.…”

Section: Resultsmentioning

confidence: 99%

Hydrolyzable Tannins as Antioxidants in the Leaf Extract of Eucalyptus globulus Possessing Tyrosinase and Hyaluronidase Inhibitory Activities

Sugimoto¹,

Nakagawa²,

Hayashi³

et al. 2009

FSTR

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The aqueous ethanolic extract of Eucalyptus globulus leaves has been used as an antioxidant in food additives. From the extract, five ellagitannins and four gallotannins were isolated as the major antioxidative components. Heterophylliin A, 1,3-di-O-galloyl-4,6-hexahydroxydiphenoyl-β-D-glucose, 1,2,4-tri-Ogalloyl-β-D-glucose, 1,2,3,6-tetra-O-galloyl-β-D-glucose and 1,2,4,6-tetra-O-galloyl-β-D-glucose are the first to be isolated from this plant. These hydrolyzable tannins exhibited more potent antioxidant activity (superoxide dismutase-like activity) than ascorbic acid, as well as inhibitory activities against tyrosinase and hyaluronidase. Thus, the eucalyptus leaf extract may be useful in food and cosmetics for not only antioxidation, but also anti-melanogenesis, anti-allergy and anti-inflammation.

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Section: Resultsmentioning

confidence: 99%

Hydrolyzable Tannins as Antioxidants in the Leaf Extract of Eucalyptus globulus Possessing Tyrosinase and Hyaluronidase Inhibitory Activities

Sugimoto¹,

Nakagawa²,

Hayashi³

et al. 2009

FSTR

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“…Antimicrobial property of tannin is wellestablished. [38][39][40][41] A number of interesting novel secondary metabolites such as elligitannin and punicalagin have been isolated. 7,8) The high activity of P. granatum against all strains of E. coli O157 : H7 examined, espectially in terms of VT inhibition, could allow its use in the treatment of E. coli O157 : H7 infection.…”

Section: Resultsmentioning

confidence: 99%

Inhibitory Effects of Active Compounds from Punica granatum Pericarp on Verocytotoxin Production by Enterohemorrhagic Escherichia coli O157 : H7

Voravuthikunchai

Sririrak

Limsuwan

et al. 2005

JOURNAL OF HEALTH SCIENCE

102

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Punica granatum (P. granatum) Linn. pericarp has been commonly employed as a crude drug in Thai traditional medicines for the treatment of diarrhea. The antibacterial activity of extracts from P. granatum pericarp against different strains of enterohemorrhagic Escherichia coli (E. coli) O157 : H7 and other strains of enterohemorrhagic E. coli were investigated. Successive chloroform, 95% ethanol, and water extracts of the plant were examined. The ethanolic extract was found to be the most effective against all the strains examined. Both the ethyl acetate and n-butanol fractions of P. granatum pericarp were demonstrated to have high activity with the highest minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values of 0.05 and 0.05 and 0.39 and 0.19 mg/ml, respectively. The inhibitory effects of both fractions on the production of verocytotoxin (VT)1 and VT2 by enterohemorrhagic E. coli O157 : H7 was observed at very low concentrations of 1/10 of the MIC value (0.05-0.09 mg/ml, respectively). Phytochemical screening of the ethanolic extracts demonstrated that they contain flavonoids, sterols, triterpenes, phenols, and tannins. Our findings suggest that an appropriate bioactive compound may be developed from P. granatum pericarp as alternative treatment for this E. coli O157 : H7 infection. The crude plant may also be administered to prevent VT production in the human intestine to solve the problem of subinhibitory effects from the use of antibiotics.

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“…For P. granatum specifically, the hexane fraction from stems (MIC: 40-71.6 µg/mL) exhibited better antifungal activity against the three clinical isolates of P. brasiliensis than extracts from leaves and fruits, indicating that the plant is a potential source of new antimicrobial compounds ( Table 1). The presence of flavonoids and tannins in the Punicaceae species is responsible for several biological activities (Hussein et al, 1997). However, these substances were in more polar, ethanol or aqueous fractions.…”

Section: Discussionmentioning

confidence: 99%

Antifungal activity of extracts of some plants used in Brazilian traditional medicine against the pathogenic fungusParacoccidioides brasiliensis

Johann¹,

Cisalpino

Watanabe

et al. 2010

Pharmaceutical Biology

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Tannins from the leaves of Punica granatum

Cited by 86 publications

References 7 publications

Hydrolyzable Tannins as Antioxidants in the Leaf Extract of Eucalyptus globulus Possessing Tyrosinase and Hyaluronidase Inhibitory Activities

Hydrolyzable Tannins as Antioxidants in the Leaf Extract of Eucalyptus globulus Possessing Tyrosinase and Hyaluronidase Inhibitory Activities

Inhibitory Effects of Active Compounds from Punica granatum Pericarp on Verocytotoxin Production by Enterohemorrhagic Escherichia coli O157 : H7

Antifungal activity of extracts of some plants used in Brazilian traditional medicine against the pathogenic fungusParacoccidioides brasiliensis

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