Targeted antiviral treatment using non-ionizing radiation therapy for SARS-CoV-2 and viral pandemics preparedness: Technique, methods and practical notes for clinical application

Abstract

Objective Pandemic outbreaks necessitate effective responses to rapidly mitigate and control the spread of disease and eliminate the causative organism(s). While conventional chemical and biological solutions to these challenges are characteristically slow to develop and reach public availability; recent advances in device components operating at Super High Frequency (SHF) bands (3–30 GHz) of the electromagnetic spectrum enable novel approaches to such problems. Methods Based on experimentally documented evidence, a clinically relevant in situ radiation procedure to reduce viral loads in patients is devised and presented. Adapted to the currently available medical device technology to cause viral membrane fracture, this procedure selectively inactivates virus particles by forced oscillations arising from Structure Resonant Energy Transfer (SRET) thereby reducing infectivity and disease progression. Results Effective resonant frequencies for pleiomorphic Coronavirus SARS-CoV-2 is calculated to be in the 10–17 GHz range. Using the relation y = -3.308x + 42.9 with x and y representing log10 number of virus particles and the clinical throat swab Ct value respectively; in situ patient–specific exposure duration of ~15x minutes can be utilized to inactivate up to 100% of virus particles in the throat-lung lining, using an irradiation dose of 14.5 ± 1 W/m2; which is within the 200 W/m2 safety standard stipulated by the International Commission on Non-Ionizing Radiation Protection (ICNIRP). Conclusions The treatment is designed to make patients less contagious enhancing faster recoveries and enabling timely control of a spreading pandemic. Advances in knowledge The article provides practically applicable parameters for effective clinical adaptation of this technique to the current pandemic at different levels of healthcare infrastructure and disease prevention besides enabling rapid future viral pandemics response.

Effects of electromagnetic waves on pathogenic viruses and relevant mechanisms: a review

“…A similar phenomenon was also observed for viruses such as SARS-CoV-2 and H3N1 [ 13 , 14 ]. Moreover, the inactivation of viruses by electromagnetic waves did not cause degradation of the viral RNA genome [ 1 , 13 , 14 ]. Therefore, physical resonance but not thermal effects contributed to the inactivation of the H3N2 virus [ 13 ].…”

“…In addition, the discovery of the physical resonance properties of electromagnetic waves is of great significance in the field. As long as the resonant frequency between a certain viral body and electromagnetic waves is known, all viruses within the resonant frequency range of the wound can be targeted, which is not possible with traditional virus inactivation techniques [ 13 , 14 , 26 ]. The electromagnetic inactivation of viruses is a prospective study with great value and potential for research and application.…”

“…The resonant energy transfer effect of electromagnetic waves could generate sufficient stress to disrupt the viral envelope structure. For enveloped viruses, infectivity or certain activities are usually reduced or completely lost after envelope disruption [ 13 , 14 ]. Yang [ 13 ] directly exposed influenza virus H3N2 (H3N2) and influenza virus H1N1 (H1N1) to microwaves at 8.35 GHz, 320 W/m² and 7 GHz, 308 W/m², respectively, for 15 min.…”

“…However, only 38% of the H3N2 virus was inactivated at the theoretical threshold of 82 W/m 2 , which indicated that the efficiency of electromagnetic radiation-mediated inactivation of the virus was closely related to the power density. Based on this study, Barbora [ 14 ] calculated the resonant frequency range (8.5–20 GHz) between electromagnetic waves and SARS-CoV-2 and deduced that the exposure of 7.5 × 10 14 m − 3 SARS-CoV-2 virus particles to electromagnetic waves with frequencies of 10–17 GHz and a power density of 14.5 ± 1 W/m 2 for approximately 15 min would result in 100% inactivation. A recent study by Wang [ 19 ] clarified that the resonant frequencies of SARS-CoV-2 are 4 and 7.5 GHz, confirming the existence of resonant frequencies independent of virus titer.…”

“…The resonant frequency and power dose were determined by the physical characteristics of the virus, such as the particle size and elasticity, and all of the viruses located in the resonant frequency could be efficiently targeted and inactivated. Due to the high penetration, lack of ionizing radiation, and good safety, the nonthermal SRET effect-mediated inactivation of viruses is promising in the treatment of human malignant diseases caused by pathogenic viruses [ 14 , 26 ].…”