Targeted Cranial Bone Transport Distraction Is Enhanced Using a Novel Device

Transport Distraction Osteogenesis With Recombinant Human Bone Morphogenic Protein-2 for Large Calvarial Defect Reconstruction

“…In previous reports, the size ratio of the transport disc to calvarial defect ranged from 19% to 50%. [1][2][3][4][5][6][7][8][9][10] In this study, we designed the transport disc size for a ratio of 18%, smaller than any previous study ( Table 3). The length of our transport disc was 8 mm, which was the smallest size that permitted fixation to the distraction device.…”

“…Because the calvarium has a round surface, transport discs should pass along a similarly curved area in most cases. 9,10,29 Two animals in the experimental group were excluded from the study because of infection at the site of distraction despite sealing the injection inlet with a silicone membrane in an effort to prevent retrograde infection. We guess that the exposed rod of distraction device may be an alternative route of the infection.…”

“…[1][2][3][4][5][6][7][8][9][10] One possible reason which makes this procedure not being widely used until now is the inconsistency of the results. Some studies reported TDO was effective for calvarial reconstruction.…”

Evaluation of Cranial Bone Transport Distraction With and Without Adipose Grafting

“…7-10 We have previously reported on a novel 3-footplate device to best control the transport segment and optimize contour around the curved topography present in the cranium. 7 Biology of distraction osteogenesis relies on tension applied to a central callus as the 2 bone segments are pulled apart, promoting tissue proliferation and biosynthetic function. 8,[24][25][26] The callus, or regenerate, ossifies akin to fracture healing with presence and stimulation of osteogenic cells during expansion and mineralization of matrix.…”

“…We have previously described a novel 3-footplate device that optimizes 3-dimensional control in repositioning this transport segment. 7 Adipose grafting has been shown to enhance healing and regeneration secondary to adipose tissue's preponderance of mesenchymal stem cells and its proangiogenic capacity. 11 When applied to chronic wounds and burns, adipose grafting has shown to improve healing by enhancing vasculogenesis and producing epithelial cell differentiation.…”