Targeted delivery and apoptosis induction of trans-resveratrol-ferulic acid loaded chitosan coated folic acid conjugate solid lipid nanoparticles in colon cancer cells

Kumar, Chiranjeev; Thangam, Ramar; Mary, Soloman Agnes; Perumal, Ramesh Kannan; Gopinath, Arun; Madhan, Balaraman

doi:10.1016/j.carbpol.2019.115682

Cited by 132 publications

(50 citation statements)

References 59 publications

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“…In cancers, the overexpression of FRs leads to an increased intracellular concentration of folate, a nutrient that sustains the rapid and uncontrolled tumor cell proliferation [ 106 , 107 ]. Folate enrichment of nanoparticles can increase the selectivity of the drug-delivery systems for colorectal tumor cells, improving, therefore, therapy efficacy [ 108 , 109 , 110 , 111 , 112 , 113 , 114 ].…”

Section: Targeting Strategies For Drug-delivery Systems In Crcmentioning

confidence: 99%

Current Landscape in Organic Nanosized Materials Advances for Improved Management of Colorectal Cancer Patients

et al. 2021

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Globally, colorectal cancer (CRC) ranks as one of the most prevalent types of cancers at the moment, being the second cause of cancer-related deaths. The CRC chemotherapy backbone is represented by 5-fluorouracil, oxaliplatin, irinotecan, and their combinations, but their administration presents several serious disadvantages, such as poor bioavailability, lack of tumor specificity, and susceptibility to multidrug resistance. To address these limitations, nanomedicine has arisen as a powerful tool to improve current chemotherapy since nanosized carriers hold great promise in improving the stability and solubility of the drug payload and enhancing the active concentration of the drug that reaches the tumor tissue, increasing, therefore, the safety and efficacy of the treatment. In this context, the present review offers an overview of the most recent advances in the development of nanosized drug-delivery systems as smart therapeutic tools in CRC management and highlights the emerging need for improving the existing in vitro cancer models to reduce animal testing and increase the success of nanomedicine in clinical trials.

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Section: Targeting Strategies For Drug-delivery Systems In Crcmentioning

confidence: 99%

Current Landscape in Organic Nanosized Materials Advances for Improved Management of Colorectal Cancer Patients

et al. 2021

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“…By inhibition of TNF-receptor associated factor 6 (TRAF6), resveratrol inhibits EMT to reduce the invasion of prostate cancer cells [55]. In colon cancer cells, resveratrol-loaded solid lipid nanoparticles remarkably stimulate apoptotic cell death to diminish the growth and proliferation of cancer cells [56]. In addition to apoptosis, resveratrol induces cell cycle arrest in cancer cells [57,58].…”

Section: Resveratrol In the Treatment Of Cancermentioning

confidence: 99%

Natural products and phytochemical nanoformulations targeting mitochondria in oncotherapy: an updated review on resveratrol

et al. 2020

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Mitochondria are intracellular organelles with two distinct membranes, known as an outer mitochondrial membrane and inner cell membrane. Originally, mitochondria have been derived from bacteria. The main function of mitochondria is the production of ATP. However, this important organelle indirectly protects cells by consuming oxygen in the route of energy generation. It has been found that mitochondria are actively involved in the induction of the intrinsic pathways of apoptosis. So, there have been efforts to sustain mitochondrial homeostasis and inhibit its dysfunction. Notably, due to the potential role of mitochondria in the stimulation of apoptosis, this organelle is a promising target in cancer therapy. Resveratrol is a non-flavonoid polyphenol that exhibits significant pharmacological effects such as antioxidant, anti-diabetic, anti-inflammatory and anti-tumor. The anti-tumor activity of resveratrol may be a consequence of its effect on mitochondria. Multiple studies have investigated the relationship between resveratrol and mitochondria, and it has been demonstrated that resveratrol is able to significantly enhance the concentration of reactive oxygen species, leading to the mitochondrial dysfunction and consequently, apoptosis induction. A number of signaling pathways such as sirtuin and NF-κB may contribute to the mitochondrial-mediated apoptosis by resveratrol. Besides, resveratrol shifts cellular metabolism from glycolysis into mitochondrial respiration to induce cellular death in cancer cells. In the present review, we discuss the possible interactions between resveratrol and mitochondria, and its potential application in cancer therapy.

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“…Since cancer cells overexpress folic acid receptors, coating the nanoparticles with its ligand, folic acid would increase the chances of availability, the specific target of cancer cells and conjugating properties. Hence, chitosan-coated-RES-FER-loaded SLNs along with stearic acid that has a surface 'decorated' [156] with folic acid were prepared.…”

Section: Solid Lipid Nanoparticles Loaded With Res In the Treatment Omentioning

confidence: 99%

“…The expression of cytochrome C indicates that apoptosis occurs through the mitochondria-dependent cellular apoptosis and activating caspases [160]. Furthermore, C-RSV-FER-FA-SLNs have arrested the cells for being in the G0/G1 phase of the cell cycle [156,160] and did not allow the cells to replicate characteristic of the RES property in using as an anti-cancer agent. Hence C-RSV-FER-FA-SLNs can be used as an anti-cancer agent in the treatment of colon cancer.…”

Section: Solid Lipid Nanoparticles Loaded With Res In the Treatment Omentioning

confidence: 99%

Resveratrol Nanoparticles: A Promising Therapeutic Advancement over Native Resveratrol

et al. 2020

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The importance of fruit-derived resveratrol (RES) in the treatment of various diseases has been discussed in various research publications. Those research findings have indicated the ability of the molecule as therapeutic in the context of in vitro and in vivo conditions. Mostly, the application of RES in in vivo conditions, encapsulation processes have been carried out using various nanoparticles that are made of biocompatible biomaterials, which are easily digested or metabolized, and RES is absorbed effectively. These biomaterials are non-toxic and are safe to be used as components in the biotherapeutics. They are made from naturally available by-products of food materials like zein or corn or components of the physiological system as with lipids. The versatility of the RES nanoparticles in their different materials, working range sizes, specificity in their targeting in various human diseases, and the mechanisms associated with them are discussed in this review.

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Targeted delivery and apoptosis induction of trans-resveratrol-ferulic acid loaded chitosan coated folic acid conjugate solid lipid nanoparticles in colon cancer cells

Cited by 132 publications

References 59 publications

Current Landscape in Organic Nanosized Materials Advances for Improved Management of Colorectal Cancer Patients

Current Landscape in Organic Nanosized Materials Advances for Improved Management of Colorectal Cancer Patients

Natural products and phytochemical nanoformulations targeting mitochondria in oncotherapy: an updated review on resveratrol

Resveratrol Nanoparticles: A Promising Therapeutic Advancement over Native Resveratrol

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