Targeted Photothermal Ablation of Murine Melanomas with Melanocyte-Stimulating Hormone Analog–Conjugated Hollow Gold Nanospheres

Lü, Wei; Xiong, Chiyi; Zhang, Guodong; Huang, Qian; Zhang, Rui; Zhang, Jin Z.; Li, Chun

doi:10.1158/1078-0432.ccr-08-1480

Cited by 311 publications

(318 citation statements)

References 38 publications

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“…PEG has shown to be the most effective capping agent for HGNs, stabilizing the nanoparticles against aggregation, caused by both increased salt concentration (up to 5 M) and changes in pH [222,223]. The intracellular uptake of bioconjugated HGNs was confirmed by both excised tissue and by (18F)-fluorodeoxyglucose positron emission tomography [72]. The mechanism of cellular uptake was later determined to be, by the same author, initiated by agonist receptor binding followed by transcellular transport by tumor vessels, of the NDP-MSH-conjugated PEGylated HAuNS (NDP-MSH-PEG-HAuNS).…”

Section: Pta With Hgnsmentioning

confidence: 93%

“…Structures should ideally be spherical with diameters in the range of 20-100 nm [69][70][71][72]. This promotes both optimal cell penetration and bioclearance [70,71,73].…”

Section: Metal Nanostructuresmentioning

confidence: 99%

“…However, dissolvable template mediated approaches typically produce structures that are larger than 100 nm, making them undesirable for most biological applications where particles should be in the 20-100 nm size regime [72,74,80]. Additionally, removal of templates generally involves the introduction of impurities and adds an additional step in the synthetic process which increases both the difficulty of nanoparticle preparation and the time involved for synthesis [90][91][92].…”

Section: Amorphous Template Mediated Approaches To Synthesismentioning

confidence: 99%

“…There has been an increasing interest in using HGNs in PTA applications [72,78]. In addition to their small size, spherical shape, biocompatibility, and lack of susceptibility to photobleaching, their extinction peaks can be easily tuned to the NIR [60,78,79,221].…”

Section: Pta With Hgnsmentioning

confidence: 99%

“…In 2009, Lu et al reported the successful HGN mediated ablation of melanoma in vivo using a mouse model [72]. Here, NIR absorbing HGNs with an average outer diameter of ∼43.5 nm and a shell thickness of 3-4 nm were stabilized with polyethylene glycol (PEG) and attached to an ∝-melanocyte-stimulating hormone (MSH) analog, [Nle4,D-Phe7]a-MSH (NDP-MSH), targeting the melanocortin type-1 receptor over-expressed in melanoma.…”

Section: Pta With Hgnsmentioning

confidence: 99%

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Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.

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Section: Pta With Hgnsmentioning

confidence: 93%

“…Structures should ideally be spherical with diameters in the range of 20-100 nm [69][70][71][72]. This promotes both optimal cell penetration and bioclearance [70,71,73].…”

Section: Metal Nanostructuresmentioning

confidence: 99%

Section: Amorphous Template Mediated Approaches To Synthesismentioning

confidence: 99%

Section: Pta With Hgnsmentioning

confidence: 99%

Section: Pta With Hgnsmentioning

confidence: 99%

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Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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Theranostic Applications of Gold Core–Shell Structured Nanoparticles

Lü

Melancon

2011

Nanoplatform‐Based Molecular Imaging

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Gold core-shell nanostructures have unique optical properties due to strong and tunable surface plasmon resonance, which is a collective oscillation of conduction-band electrons within the structures induced by the oscillating dipole of a resonant wavelength of light. By varying the core composition, core radius, and shell thickness, the optical resonances of core-shell nanostructures-including silica-core gold nanoshells, hollow gold nanoshells, and hollow gold nanocages-can be continuously tuned through wavelengths ranging from the ultraviolet region to the infrared region. These novel nanoparticles have been shown to be useful for a variety of potential applications in biomedicine, including cancer molecular optical imaging, controlled drug delivery, and photothermal ablation therapy. In this chapter, we provide an up-to-date summary of the synthesis, characterization, and preclinical evaluation of gold core-shell nanostructures. We also touch upon the development of multifunctional gold core-shell nanoparticles for theranostic applications (i.e., simultaneous treatment and diagnosis) for cancer. INTRODUCTIONTheranostics are agents that have both a treatment and a diagnostic function. The theranostic approach tailors treatment to the individual patient and has the potential to offer improved therapeutic efficacy, reduced side effects, and improved cost effectiveness. Nanotechnology as an enabling technology has attracted much attention in recent years. In particular, multifunctional nanomaterials incorporating both diagnostic and therapeutic functions have been created and evaluated for cancer theranostic applications.Nanomaterials that interact with light provide a unique opportunity [1]. These photocoupling agents can not only report the molecular-specific signatures of cancer with high sensitivity and high spatial resolution but also mediate photochemical, photothermal, and photomechanical responses that can be harnessed to kill cancer cells. Nanoplatform-Based Molecular Imaging Edited by Xiaoyuan Chen

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