Targeting canine mammary tumours via gold nanoparticles functionalized with promising Co(<scp>II</scp>) and Zn(<scp>II</scp>) compounds

Raposo, Luís R.; Roma‐Rodrigues, Catarina; Jesus, João Pedro Santiago de; Martins, Luísa M. D. R. S.; Pombeiro, Armando J. L.; Baptista, Pedro V.; Fernandes, Alexandra R.

doi:10.1111/vco.12298

Cited by 14 publications

(9 citation statements)

References 22 publications

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“…In human medicine, several nanoparticle-based drugs are registered by the Food and Drug Administration, and others are currently undergoing clinical trials [47]. In veterinary medicine, there are just a few preclinical studies on the use of liposomes and nanoparticles to improve cancer treatment in dogs and cats [48,49]. A few clinical trials of liposomal Dox have been performed on dogs to test their use in humans [26,50].…”

Section: Discussionmentioning

confidence: 99%

Enhanced Cytotoxic Effect of Doxorubicin Conjugated to Glutathione-Stabilized Gold Nanoparticles in Canine Osteosarcoma—In Vitro Studies

et al. 2021

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Osteosarcoma (OSA) is the most common malignant bone neoplasia in humans and dogs. In dogs, treatment consists of surgery in combination with chemotherapy (mostly carboplatin and/or doxorubicin (Dox)). Chemotherapy is often rendered ineffective by multidrug resistance. Previous studies have revealed that Dox conjugated with 4 nm glutathione-stabilized gold nanoparticles (Au-GSH-Dox) enhanced the anti-tumor activity and cytotoxicity of Dox in Dox-resistant feline fibrosarcoma cell lines exhibiting high P-glycoprotein (P-gp) activity. The present study investigated the influence of Au-GSH-Dox on the canine OSA cell line D17 and its relationship with P-gp activity. A human Dox-sensitive OSA cell line, U2OS, served as the negative control. Au-GSH-Dox, compared to free Dox, presented a greater cytotoxic effect on D17 (IC50 values for Au-GSH-Dox and Dox were 7.9 μg/mL and 15.2 μg/mL, respectively) but not on the U2OS cell line. All concentrations of Au-GSH (ranging from 10 to 1000 μg/mL) were non-toxic in both cell lines. Inhibition of the D17 cell line with 100 μM verapamil resulted in an increase in free Dox but not in intracellular Au-GSH-Dox. The results indicate that Au-GSH-Dox may act as an effective drug in canine OSA by bypassing P-gp.

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Section: Discussionmentioning

confidence: 99%

Enhanced Cytotoxic Effect of Doxorubicin Conjugated to Glutathione-Stabilized Gold Nanoparticles in Canine Osteosarcoma—In Vitro Studies

et al. 2021

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“…Gold nanoparticles (AuNPs) are promising drug delivery systems with a wide variety of applications regarding imaging, diagnostic, and targeted therapy, exhibiting unique chemical and physical properties. , AuNPs can be delivered systemically, presenting long circulatory half-lives and causing low immunogenic responses . AuNPs have demonstrated the potential to enhance the cell uptake of a variety of compounds and therapeutic moieties, allowing the delivery of increased amounts of active components to the cells. − …”

Section: Introductionmentioning

confidence: 99%

Improving the Anti-inflammatory Response via Gold Nanoparticle Vectorization of CO-Releasing Molecules

Fernandes

Mendonça-Martins

Santos

et al. 2020

ACS Biomater. Sci. Eng.

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CO-releasing molecules (CORMs) have been widely studied for their anti-inflammatory, antiapoptotic, and antiproliferative effects. CORM-3 is a water-soluble Ru-based metal carbonyl complex, which metallates serum proteins and readily releases CO in biological media. In this work, we evaluated the anti-inflammatory and wound-healing effects of gold nanoparticles–CORM-3 conjugates, AuNPs@PEG@BSA·Ru(CO) x , exploring its use as an efficient CO carrier. Our results suggest that the nanoformulation was capable of inducing a more pronounced cell effect, at the anti-inflammatory level and a faster tissue repair, probably derived from a rapid cell uptake of the nanoformulation that results in the increase of CO inside the cell.

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“…The development of new complexes bearing different types of pyrazole-based ligands demonstrated the potential use of these complexes as antiproliferative agents [149]. and TS265 and the application of AuNPs as a drug delivery system to improve the anticancer efficacy of these compounds in a new canine mammary tumor (FR37-CMT) [150]. The same group formulated a multifunctional nanovectorization system using gold nanoparticles to enhance cytotoxic of TS265.…”

Section: Other Complexesmentioning

confidence: 99%

Inorganic Coordination Chemistry: Where We Stand in Cancer Treatment?

Pedrosa¹,

Carvalho²,

Baptista³

et al. 2018

Basic Concepts Viewed From Frontier in Inorganic Coordination Chemistry

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Metals have unique characteristics such as variable coordination modes, redox activity, and reactivity being indispensable for several biochemical processes in cells. Due to their reactivity, their concentration is tightly regulated inside the cells, and abnormal concentrations are associated with many disorders, such as cancer. As such metal complexes turned out to be very attractive as potential anticancer agents. The discovery of cisplatin was a crucial moment, which prompted the interest in Pt(II) and other metal complexes as potential anticancer agents. This chapter highlights the state of the art on metal complexes in cancer therapy, highlighting their uptake mechanisms, biological targets, toxicity, and drug resistance. Finally, based on the importance of selective target of cancer cells, drug delivery systems will also be discussed.

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Targeting canine mammary tumours via gold nanoparticles functionalized with promising Co(II) and Zn(II) compounds

Abstract: TS262 and TS265 are compounds with potential in the treatment of CMTs. NanoTS262 and NanoTS265 demonstrate that such simple nanovectorization via gold nanoparticles shows tremendous potential as anti-cancer formulations, which may easily be expanded to suit other cargo.

Cited by 14 publications

References 22 publications

Enhanced Cytotoxic Effect of Doxorubicin Conjugated to Glutathione-Stabilized Gold Nanoparticles in Canine Osteosarcoma—In Vitro Studies

Enhanced Cytotoxic Effect of Doxorubicin Conjugated to Glutathione-Stabilized Gold Nanoparticles in Canine Osteosarcoma—In Vitro Studies

Improving the Anti-inflammatory Response via Gold Nanoparticle Vectorization of CO-Releasing Molecules

Inorganic Coordination Chemistry: Where We Stand in Cancer Treatment?

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