Targeting Cell Signaling and Apoptotic Pathways by Luteolin: Cardioprotective Role in Rat Cardiomyocytes Following Ischemia/Reperfusion

Abstract

Myocardial ischemia often results in damaged heart structure and function, which can be restored through ischemia/reperfusion (I/R) in most cases. However, I/R can exacerbate myocardial ischemia reperfusion injury (IRI). Luteolin, a widely distributed flavonoid, a member of a group of naturally occurring polyphenolic compounds found in many fruits, vegetables and medicinal herbs, has been reported to exhibit anti-inflammatory, antioxidant and anti-carcinogenic activities. In recent years, luteolin has been shown to play an important role in the cardioprotection of IRI. However, its role and mechanism in cardioprotection against IRI has not been clearly elucidated with respect to the apoptosis pathway. The purpose of this paper is to review luteolin’s anti-apoptotic role and mechanism following I/R in rats, and indicate luteolin as a potential candidate for preventing and treating cardiovascular diseases.

Evaluation of the Wound Healing Properties of Luteolin Ointments on Excision and Incision Wound Models in Diabetic and Non-Diabetic Rats

“…Presence of hydroxyl moieties and 2-3 carbon double bond are responsible for its several biochemical and pharmacological activities [18,19] like anti-inflammatory, antioxidant [6,[18][19][20][21][22], anticancer [18,22], antimicrobial [19,22], anti-allergic [22], anti-diabetic [19]. These evidence indicated that many biological activities of Luteolin (e.g.…”

“…Luteolin (3',4',5,7-tetrahydroxyflavone), which is naturally distributed among several plant species such as medicinal plants, vegetables and fruits [18,21,22], is structurally classified under the group of flavones [18][19][20]. Presence of hydroxyl moieties and 2-3 carbon double bond are responsible for its several biochemical and pharmacological activities [18,19] like anti-inflammatory, antioxidant [6,[18][19][20][21][22], anticancer [18,22], antimicrobial [19,22], anti-allergic [22], anti-diabetic [19].…”

Luteolin, a Bioflavonoid Inhibits Colorectal Cancer through Modulation of Multiple Signaling Pathways: A Review

“…Luteolin is heat stable and losses due to cooking are relatively low (Le Marchand, 2002). Luteolin, possess many beneficial properties including antioxidant (Ashokkumar and Sudhandiran, 2008), anti-inflammatory (Nishitani et al, 2013), cardio protective (Xu et al, 2012), anti-diabetic (Salib et al, 2013) and anti-proliferative (Ashokkumar and Sudhandiran, 2011).…”

Inhibition of microRNA-101 attenuates hypoxia/reoxygenation-induced apoptosis through induction of autophagy in H9c2 cardiomyocytes

“…Myocardial tissue injury induced by ischemia and hypoxia is a major factor underlying the development of fatal diseases. The main cause of myocardial ischemic injury is myocardial cell apoptosis induced by myocardial hypoxia (5). Furthermore, subsequent reoxygenation may further aggravate the damage (6).…”