Targeting DNA topoisomerase II with podophyllotoxin aza-analogue

Iida, Akira; Kano, Masahiro; Kubota, Yoshihiro; Koga, Kenji; Tomioka, Kiyoshi

doi:10.1016/s0960-894x(97)10029-4

Cited by 9 publications

(1 citation statement)

References 10 publications

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“…According to the biological properties of podophyllotoxin, many derivatives were semisynthesized, such as etoposide and teniposide (semi‐synthetic derivatives of podophyllotoxin), and used in cancer chemotherapy against various cancer . According to the structure of microtubule assembly inhibitor podophyllotoxin 3 and topo II inhibitor etoposide, Akira's team developed compounds 1 and 2 (Figure ) with the dehydroxyl C ring, exhibited cytotoxicity due to inhibition of microtubule assembly . However, compound 1 did not inhibit topo II activity.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives as potential antitumor candidate

Zhu

et al. 2016

Chem Biol Drug Des

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A novel class of tetrahydroisoquinoline derivatives was designed and synthesized as antitumor agents and evaluated for their in vitro and in vivo biological activities. The antiproliferative activities of all the target compounds on HUVEC, MCF-7, and HT-29 were evaluated. Compared with colchicine (1.04 × 10 μm), 17d and 17e exhibited outstanding activity on MCF-7 with IC values 0.26 × 10 μm and 0.89 × 10 μm in cell cytotoxicity assay. The tubulin polymerization assay demonstrated that 17d and 17e exhibited better inhibition rate. In the MCF-7-xenograft mouse model that was treated with 17d and 17e by intraperitoneal injection, the tumor weight was decreased at same rate with tamoxifen, and relative tumor proliferation rates were 59.48% and 41.33%, while tamoxifen was 45.08% with a daily dose of 20 mg/kg, which were demonstrated potent in vivo efficacy.

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Section: Introductionmentioning

confidence: 99%

Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives as potential antitumor candidate

Zhu

et al. 2016

Chem Biol Drug Des

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Advancements in tetronic acid chemistry. Part 2: Use as a simple precursor to privileged heterocyclic motifs

et al. 2016

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This work highlights the literature of one of the most valuable moieties in the field of organic chemistry. In this review, the chemistry of tetronic acid as a simple precursor to privileged heterocyclic motifs is described. The synthetic procedures of different fused heterocycles incorporating a furan moiety are described. Fused heterocycles are classified as bicyclic, tricyclic, tetracyclic and spiro-fused pyran derivatives.

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Bicyclic 5-6 Systems with One Bridgehead (Ring Junction) Nitrogen Atom: One Extra Heteroatom 1:0

Couty

Evano

2008

Comprehensive Heterocyclic Chemistry III

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Targeting DNA topoisomerase II with podophyllotoxin aza-analogue

Cited by 9 publications

References 10 publications

Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives as potential antitumor candidate

Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives as potential antitumor candidate

Advancements in tetronic acid chemistry. Part 2: Use as a simple precursor to privileged heterocyclic motifs

Bicyclic 5-6 Systems with One Bridgehead (Ring Junction) Nitrogen Atom: One Extra Heteroatom 1:0

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