“…Systems capable of controlling DNA and RNA G-quadruplex structures would be useful for the modulation of various cellular events and different G-quadruplex-targeting ligands have been described [ 17 , 18 ], including phthalocyanine [ 19 ], porphyrin [ 20 ], and other derivatives [ 21 , 22 ]. From these, peptides represent a class of highly specific ligands with a greater degree of functionality including binding on-off switching, cellular penetration, and the ability to target organelles [ 23 , 24 , 25 , 26 , 27 ]. Among them, the N-terminal domain of the RNA helicase associated with AU-rich element (RHAU), a member of the human DEAH (Asp-Glu-Ala-His) box family of RNA helicases, which includes a specific motif, named RSM, necessary for G-quadruplex recognition and interaction (aa 54–66) [ 28 ], has recently raised the interest of several authors [ 29 , 30 , 31 , 32 ].…”