Targeting glucose metabolism for cancer therapy

Hamanaka, Robert B.; Chandel, Navdeep S.

doi:10.1083/jcb1964oia3

Cited by 31 publications

(43 citation statements)

References 27 publications

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“…Therefore, our data indicate that the epithelial expression of MMP-1 represses the OCR, induces the expression of HIF-1␣ under normoxic conditions, and decreases the production of ROS. This finding is similar to that described in cancer cells which have increased glucose metabolism (25).…”

Section: Discussionsupporting

confidence: 80%

Matrix Metalloproteinase (MMP)-1 Induces Lung Alveolar Epithelial Cell Migration and Proliferation, Protects from Apoptosis, and Represses Mitochondrial Oxygen Consumption

Herrera

Cisneros

Maldonado

et al. 2013

Journal of Biological Chemistry

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Background:In IPF MMP-1 is up-regulated and expressed in alveolar epithelial cells. Result: Transfection of MMP-1 in MLE cells increased proliferation/migration, protected from apoptosis, repressed oxygen consumption ratio and ROS production, and stimulated HIF-1␣. Conclusion: MMP-1 inhibits mitochondrial function and contributes to a proliferative/migratory and anti-apoptotic phenotype. Significance: MMP-1 promotes the Warburg effect characterized by increased aerobic glycolysis and HIF-1␣ during normoxia.

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Section: Discussionsupporting

confidence: 80%

Matrix Metalloproteinase (MMP)-1 Induces Lung Alveolar Epithelial Cell Migration and Proliferation, Protects from Apoptosis, and Represses Mitochondrial Oxygen Consumption

Herrera

Cisneros

Maldonado

et al. 2013

Journal of Biological Chemistry

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“…In the present study, increased PKM2 expression by transfection may partially reverse the effects of PPZ in inhibiting cancer cell proliferation and inducing apoptosis. The cancer-specific metabolic transformation associated with therapeutic resistance is a promising target for cancer therapy (27,28). Response of the SGC-7901 cells was not observed subsequent to the inhibition of PKM2 by RNA interference or small-molecule inhibitors.…”

Section: Discussionmentioning

confidence: 99%

Pantoprazole inhibits human gastric adenocarcinoma SGC-7901 cells by downregulating the expression of pyruvate kinase M2

et al. 2015

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Abstract. The Warburg effect is important in tumor growth. The human M2 isoform of pyruvate kinase (PKM2) is a key enzyme that regulates aerobic glycolysis in tumor cells. Recent studies have demonstrated that PKM2 is a potential target for cancer therapy. The present study investigated the effects of pantoprazole (PPZ) treatment and PKM2 transfection on human gastric adenocarcinoma SGC-7901 cells in vitro. The present study revealed that PPZ inhibited the proliferation of tumor cells, induced apoptosis and downregulated the expression of PKM2, which contributes to the current understanding of the functional association between PPZ and PKM2. In summary, PPZ may suppress tumor growth as a PKM2 protein inhibitor.

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“…Alternatively, drugs can be encapsulated into nanocarriers 'caged' by ATP aptamer for reversibly controlling drug release on ATP's trigger. Furthermore, the intracellular level of ATP can be tuned by directly delivering ATP molecule 54,55 or adjusting other metabolic elements' concentration or activity, such as glucose level, hydrogen ion gradient and oxidative stress [56][57][58] .…”

Section: Discussionmentioning

confidence: 99%

ATP-triggered anticancer drug delivery

et al. 2014

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Stimuli-triggered drug delivery systems have been increasingly used to promote physiological specificity and on-demand therapeutic efficacy of anticancer drugs. Here we utilize adenosine-5'-triphosphate (ATP) as a trigger for the controlled release of anticancer drugs. We demonstrate that polymeric nanocarriers functionalized with an ATP-binding aptamer-incorporated DNA motif can selectively release the intercalating doxorubicin via a conformational switch when in an ATP-rich environment. The half-maximal inhibitory concentration of ATP-responsive nanovehicles is 0.24 mM in MDA-MB-231 cells, a 3.6-fold increase in the cytotoxicity compared with that of non-ATP-responsive nanovehicles. Equipped with an outer shell crosslinked by hyaluronic acid, a specific tumour-targeting ligand, the ATP-responsive nanocarriers present an improvement in the chemotherapeutic inhibition of tumour growth using xenograft MDA-MB-231 tumour-bearing mice. This ATP-triggered drug release system provides a more sophisticated drug delivery system, which can differentiate ATP levels to facilitate the selective release of drugs.

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Targeting glucose metabolism for cancer therapy

Cited by 31 publications

References 27 publications

Matrix Metalloproteinase (MMP)-1 Induces Lung Alveolar Epithelial Cell Migration and Proliferation, Protects from Apoptosis, and Represses Mitochondrial Oxygen Consumption

Matrix Metalloproteinase (MMP)-1 Induces Lung Alveolar Epithelial Cell Migration and Proliferation, Protects from Apoptosis, and Represses Mitochondrial Oxygen Consumption

Pantoprazole inhibits human gastric adenocarcinoma SGC-7901 cells by downregulating the expression of pyruvate kinase M2

ATP-triggered anticancer drug delivery

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