Targeting Phthalocyanines to Tumor Cells Using Epidermal Growth Factor Conjugates

Луценко, С. В.; Feldman, Nataliya B.; Finakova, G.V.; Посыпанова, Г. А.; Северин, С. Е.; Skryabin, K. G.; Кирпичников, М. П.; Luk’yanets, E. A.; Vorozhtsov, Georgy N.

doi:10.1159/000030066

Cited by 22 publications

(11 citation statements)

References 11 publications

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“…EGF is internalised into the cell via receptor-mediated endocytosis 147. To date, this strategy has not been thoroughly investigated; only one research group has reported (in 1999) data on the photosensitiser-EGF model 148. Lutsenko and colleagues focused their research on aluminium and cobalt disulphonated PCs.…”

Section: Epidermal Growth Factormentioning

confidence: 99%

Unique Diagnostic and Therapeutic Roles of Porphyrins and Phthalocyanines in Photodynamic Therapy, Imaging and Theranostics

Josefsen

Boyle²

2012

Theranostics

521

352

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Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types. Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms. The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.

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Section: Epidermal Growth Factormentioning

confidence: 99%

Unique Diagnostic and Therapeutic Roles of Porphyrins and Phthalocyanines in Photodynamic Therapy, Imaging and Theranostics

Josefsen

Boyle²

2012

Theranostics

521

352

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“…A novel approach to photosensitizer targeting has recently been reported using epidermal growth factor (EGF) [78]. Both AlPc and CoPc were covalently labeled with EGF.…”

Section: Phthalocyanine Deliverymentioning

confidence: 99%

“…As was stated previously, Pc4 is about to enter clinical trials for the treatment of neoplasms and has been investigated for the sterilization of blood components [23,78]. In addition, a liposomal preparation of zinc phthalocyanine (CGP55847) has been in early Phase I/II clinical trials in Switzerland for the treatment of patients with squamous cell carcinomas of the upper digestive tract [109].…”

Section: Phthalocyanines In-clinicmentioning

confidence: 99%

Current status of phthalocyanines in the photodynamic therapy of cancer

Allen

Sharman

Lier

2001

J. Porphyrins Phthalocyanines

529

269

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Photodynamic therapy is a binary treatment now accepted in clinic for various malignancies in several countries around the world. Phthalocyanine molecules are second-generation photosensitizers with enhanced photophysical and photochemical properties over those of porphyrins. They have been shown to be phototoxic against a number of cell types and tumor models. A great deal of research has been devoted to the elucidation of their mechanism of action and mode of cell death. The present paper reviews phthalocyanine pre-clinical anti-cancer research with emphasis on phthalocyanine induced apoptosis using a silicon phthalocyanine, Pc4. A brief summary of the latest clinical results using phthalocyanines is presented.

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“…The administration of the conjugate EGF-Pc-(Co) strongly increased mean life spans and mean survival time of animals bearing tumors. Free Pc(Co) had practically no effect on these parameters [66]. The maximal therapeutic effect needs to be optimized in relation with different schedules for the drug administration.…”

Section: Monoclonal Antibodies (Mabs)mentioning

confidence: 99%

“…To the best of our knowledge, only one article has been reported in the literature concerning the coupling of EGF with Pcs [66]. Lutsenko et al have conjugated EGF with aluminium (EGF-Pc(Al)) and cobalt disulfonated phthalocyanines (EGFPc(Co)), the EGF:Pc ratio being 1:1.…”

Section: Low-density Lipoproteins (Ldls)mentioning

confidence: 99%

Phthalocyanines Covalently Bound to Biomolecules for a Targeted Photodynamic Therapy

Taquet¹,

Frochot²,

Manneville³

et al. 2007

CMC

159

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Photodynamic therapy (PDT) is a relatively new cytotoxic treatment, predominantly used in anticancer approaches, that depends on the retention of photosensitizers in tumor and their activation after light exposure. This technology is based on the light excitation of a photosensitizer which induces very localized oxidative damages within the cells by formation of highly reactive oxygen species, the most important being singlet oxygen. Many photo-activable molecules have been synthesized such as porphyrins, chlorins and more recently phthalocyanines which present a strong light absorption at wavelengths around 670 nm and are therefore well-adapted to the optical window required for PDT application. However, the lack of selective accumulation of these photo-activable molecules within tumor tissue is a major problem in PDT, and one research area of importance is developing targeted photosensitizers. Indeed, targeted photodynamic therapy offers the advantage to enhance photodynamic efficiency by directly targeting diseased cells or tissues. Many attempts have been made to either increase the uptake of the dye by the target cells and tissues or to improve subcellular localization so as to deliver the dye to photosensitive sites within the cells. The aim of this review is to present the actual state of the development of phthalocyanines covalently conjugated with biomolecules that possess a marked selectivity towards cancer cells; for some of them their photophysical properties and photodynamic activity will be presented.

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Targeting Phthalocyanines to Tumor Cells Using Epidermal Growth Factor Conjugates

Cited by 22 publications

References 11 publications

Unique Diagnostic and Therapeutic Roles of Porphyrins and Phthalocyanines in Photodynamic Therapy, Imaging and Theranostics

Unique Diagnostic and Therapeutic Roles of Porphyrins and Phthalocyanines in Photodynamic Therapy, Imaging and Theranostics

Current status of phthalocyanines in the photodynamic therapy of cancer

Phthalocyanines Covalently Bound to Biomolecules for a Targeted Photodynamic Therapy

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