Targeting the balance of T helper cell responses by curcumin in inflammatory and autoimmune states

Rahimi, Kaveh; Ahmadi, Abbas; Hassanzadeh, Kambiz; Soleimani, Zahra; Sathyapalan, Thozhukat; Mohammadi, Asghar; Sahebkar, Amirhossein

doi:10.1016/j.autrev.2019.05.012

Cited by 62 publications

(33 citation statements)

References 142 publications

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“…For instance, VC positively influences lymphocyte development and function, and enhances T-cell proliferation and T-cell function [14,78]. CC could target regulatory T-cells and convert them into CD4+ Th1 cells to process anti-tumor effects [79,80], and improve the imbalance of Th1/Th2 subsets to process anti-inflammatory and anti-autoimmune effects [27,81]. GA showed anti-allergic effect by restoring the imbalance of Th1/Th2 subsets [82,83].…”

Section: Discussionmentioning

confidence: 99%

A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

Chen¹,

Hu²,

Hood

et al. 2020

Nutrients

119

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Novel coronaviruses (CoV) have emerged periodically around the world in recent years. The recurrent spreading of CoVs imposes an ongoing threat to global health and the economy. Since no specific therapy for these CoVs is available, any beneficial approach (including nutritional and dietary approach) is worth investigation. Based on recent advances in nutrients and phytonutrients research, a novel combination of vitamin C, curcumin and glycyrrhizic acid (VCG Plus) was developed that has potential against CoV infection. System biology tools were applied to explore the potential of VCG Plus in modulating targets and pathways relevant to immune and inflammation responses. Gene target acquisition, gene ontology and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment were conducted consecutively along with network analysis. The results show that VCG Plus can act on 88 hub targets which are closely connected and associated with immune and inflammatory responses. Specifically, VCG Plus has the potential to regulate innate immune response by acting on NOD-like and Toll-like signaling pathways to promote interferons production, activate and balance T-cells, and regulate the inflammatory response by inhibiting PI3K/AKT, NF-κB and MAPK signaling pathways. All these biological processes and pathways have been well documented in CoV infections studies. Therefore, our findings suggest that VCG Plus may be helpful in regulating immune response to combat CoV infections and inhibit excessive inflammatory responses to prevent the onset of cytokine storm. However, further in vitro and in vivo experiments are warranted to validate the current findings with system biology tools. Our current approach provides a new strategy in predicting formulation rationale when developing new dietary supplements.

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Section: Discussionmentioning

confidence: 99%

A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

Chen¹,

Hu²,

Hood

et al. 2020

Nutrients

119

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“…It has been categorized based on the role of targets and the effect of curcumin on those. Curcumin clearly diminishes mRNA production of pro-inflammatory mediators, including cytokines and relative enzymes such as cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) [166][167][168]. Apparently, this is due to it inhibitor effect of transcription factors such as activator protein (AP)-1 and nuclear factor (NF)-κB-mediated gene [143,169]; however, the direct molecular targets at low doses are not entirely clear.…”

Section: Cellular and Molecular Targets Of Curcuminmentioning

confidence: 99%

Obstacles against the Marketing of Curcumin as a Drug

Hassanzadeh

Buccarello

Dragotto

et al. 2020

IJMS

Self Cite

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Among the extensive public and scientific interest in the use of phytochemicals to prevent or treat human diseases in recent years, natural compounds have been highly investigated to elucidate their therapeutic effect on chronic human diseases including cancer, cardiovascular disease, and neurodegenerative disease. Curcumin, an active principle of the perennial herb Curcuma longa, has attracted an increasing research interest over the last half-century due to its diversity of molecular targets, including transcription factors, enzymes, protein kinases, growth factors, inflammatory cytokines, receptors, and it’s interesting pharmacological activities. Despite that, the clinical effectiveness of the native curcumin is weak, owing to its low bioavailability and rapid metabolism. Preclinical data obtained from animal models and phase I clinical studies done in human volunteers confirmed a small amount of intestinal absorption, hepatic first pass effect, and some degree of intestinal metabolism, might explain its poor systemic availability when it is given via the oral route. During the last decade, researchers have attempted with new pharmaceutical methods such as nanoparticles, liposomes, micelles, solid dispersions, emulsions, and microspheres to improve the bioavailability of curcumin. As a result, a significant number of bioavailable curcumin-based formulations were introduced with a varying range of enhanced bioavailability. This manuscript critically reviews the available scientific evidence on the basic and clinical effects and molecular targets of curcumin. We also discuss its pharmacokinetic and problems for marketing curcumin as a drug.

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“…CD4 + T cell activation and proper differentiation into T helper (Th) cells are important for establishing an adaptive immune response against foreign pathogens. However, an excessive activation of Th cells leads to inflammation and autoimmune diseases [22]. When CD4 + T cells were induced to differentiate, costunolide markedly reduced the differentiation into a population of Th1, Th2, and Th17 subsets.…”

Section: Therapeutic Potential Of Costunolidementioning

confidence: 99%

Costunolide—A Bioactive Sesquiterpene Lactone with Diverse Therapeutic Potential

Kim

Choi

2019

IJMS

103

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Sesquiterpene lactones constitute a major class of bioactive natural products. One of the naturally occurring sesquiterpene lactones is costunolide, which has been extensively investigated for a wide range of biological activities. Multiple lines of preclinical studies have reported that the compound possesses antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Many of these bioactivities are supported by mechanistic details, such as the modulation of various intracellular signaling pathways involved in precipitating tissue inflammation, tumor growth and progression, bone loss, and neurodegeneration. The key molecular targets of costunolide include, but are not limited to, intracellular kinases, such as mitogen-activated protein kinases, Akt kinase, telomerase, cyclins and cyclin-dependent kinases, and redox-regulated transcription factors, such as nuclear factor-kappaB, signal transducer and activator of transcription, activator protein-1. The compound also diminished the production and/expression of proinflammatory mediators, such as cyclooxygenase-2, inducible nitric oxide synthase, nitric oxide, prostaglandins, and cytokines. This review provides an overview of the therapeutic potential of costunolide in the management of various diseases and their underlying mechanisms.

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Targeting the balance of T helper cell responses by curcumin in inflammatory and autoimmune states

Cited by 62 publications

References 142 publications

A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System Biology Analysis

Obstacles against the Marketing of Curcumin as a Drug

Costunolide—A Bioactive Sesquiterpene Lactone with Diverse Therapeutic Potential

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