Targeting therapy-resistant cancer stem cells by hyperthermia

Oei, Arlene L.; Vriend, Lianne; Krawczyk, Przemek M.; Horsman, Michael R.; Franken, Nicolaas A.P.; Crezee, J.

doi:10.1080/02656736.2017.1279757

Cited by 67 publications

(44 citation statements)

References 170 publications

(190 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, phage-derived heat-stable proteins with hydrophobic domains could interact with receptors such as the Epidermal Growth Factor Receptor that is coupled with intracellular polyphosphoinositide mitogenic signaling as we demonstrated in 1988 (83). Thanks to the heat resistance of phage CB19, such an approach would be particularly indicated in combination with anti-cancer hyperthermia (84).…”

Section: Discussionmentioning

confidence: 94%

Phage composition of a fermented milk and colostrum product assessed by microbiome array; putative role of open reading frames in reference to cell signaling and neurological development

Pacini¹,

Ruggiero²

2019

Preprint

View full text Add to dashboard Cite

Bacteriophages (phages), Earth's most numerous biological entities, are natural constituents of alimentary matrices; in this study we describe the characterization of phage populations in a product obtained by fermentation of bovine milk and colostrum. Such characterizations were achieved using a microarray consisting of a chip covered in short DNA sequences that are specific to certain target organisms for a total of approximately 12,000 species. The only viruses evidenced by the array belonged to Siphoviridae, the largest phage family that targets bacteria and archea. The array yielded 27 iterations corresponding to a unique target. We discuss the putative role of some open reading frames of these phages in conferring health-supporting properties.

show abstract

Section: Discussionmentioning

confidence: 94%

Phage composition of a fermented milk and colostrum product assessed by microbiome array; putative role of open reading frames in reference to cell signaling and neurological development

Pacini¹,

Ruggiero²

2019

Preprint

View full text Add to dashboard Cite

show abstract

“…With improved blood flow, hypoxia is decreased, which further enhances radiation effects through an increased production of oxygen radicals. In addition, hyperthermia inhibits DNA repair, thus enhancing tumour cell killing [31,32].…”

Section: Introductionmentioning

confidence: 99%

The clinical benefit of hyperthermia in pancreatic cancer: a systematic review

Horst

Versteijne

Besselink

et al. 2017

International Journal of Hyperthermia

View full text Add to dashboard Cite

Objective: In pancreatic cancer, which is therapy resistant due to its hypoxic microenvironment, hyperthermia may enhance the effect of radio(chemo)therapy. The aim of this systematic review is to investigate the validity of the hypothesis that hyperthermia added to radiotherapy and/or chemotherapy improves treatment outcome for pancreatic cancer patients. Methods and materials: We searched MEDLINE and Embase, supplemented by handsearching, for clinical studies involving hyperthermia in pancreatic cancer patients. The quality of studies was evaluated using the Oxford Centre for Evidence-Based Medicine levels of evidence. Primary outcome was treatment efficacy; we calculated overall response rate and the weighted estimate of the population median overall survival (m p ) and compared these between hyperthermia and control cohorts. Results: Overall, 14 studies were included, with 395 patients with locally advanced and/or metastatic pancreatic cancer of whom 248 received hyperthermia. Patients were treated with regional (n ¼ 189), intraoperative (n ¼ 39) or whole-body hyperthermia (n ¼ 20), combined with chemotherapy, radiotherapy or both. Quality of the studies was low, with level of evidence 3 (five studies) and 4. The six studies including a control group showed a longer m p in the hyperthermia groups than in the control groups (11.7 vs. 5.6 months). Overall response rate, reported in three studies with a control group, was also better for the hyperthermia groups (43.9% vs. 35.3%). Conclusions: Hyperthermia, when added to chemotherapy and/or radiotherapy, may positively affect treatment outcome for patients with pancreatic cancer. However, the quality of the reviewed studies was limited and future randomised controlled trials are needed to establish efficacy. ARTICLE HISTORY

show abstract

“…3,39 Based on these cellular effects, recent studies suggest that hyperthermia could become an important strategy in targeting therapy-resistant cancer stem cells. 40 In addition, hyperthermia affects the tumor microenvironment in various ways. Among others, heat alters blood flow; although the effect varies between tumors, mild hyperthermia (< 42°C) has been shown to improve perfusion, 41 and temperatures above 42°C are likely to reduce blood flow.…”

Section: Thermal Therapies In Brain Tumorsmentioning

confidence: 99%

Thermal Therapy Approaches for Treatment of Brain Tumors in Animals and Humans

Bredlau

McCrackin

Motamarry

et al. 2016

Crit Rev Biomed Eng

View full text Add to dashboard Cite

Primary brain tumors are often aggressive, with short survival from time of diagnosis even with standard of care therapies such as surgery, chemotherapy, and radiation therapy. Thermal therapies have been extensively investigated as both primary and adjuvant therapy. Although thermal therapies are not yet widely used clinically, there have been several promising approaches demonstrated in both animals and humans. This review presents thermal therapy approaches in animal and human studies, including both hyperthermia (temperatures ~42°C–45°C) and thermal ablation (temperatures > 50°C). Hyperthermia is primarily used as adjuvant to chemotherapy and radiotherapy, and is the most widely studied radiation sensitizer where enhanced efficacy has been shown in human patients with brain cancer. Hyperthermia has additional beneficial effects such as immunogenic effects, and opening of the blood-brain barrier to potentially enhance drug delivery, for example in combination with nanoparticle drug delivery systems. Thermal ablation uses high temperatures for direct local tumor destruction, and it found its way into clinical use as laser interstitial thermal therapy (LITT). This review presents various hyperthermia and ablation approaches, including a review of different devices and methods that have been used for thermal therapies, such as radiofrequency/microwaves, laser, high-intensity focused ultrasound, and magnetic nanoparticles. Current research efforts include the combination of advanced thermal therapy devices, such as focused ultrasound with radiation, as well as the use of thermal therapies to enhance chemotherapy delivery across the blood-brain barrier.

show abstract

Targeting therapy-resistant cancer stem cells by hyperthermia

Cited by 67 publications

References 170 publications

Phage composition of a fermented milk and colostrum product assessed by microbiome array; putative role of open reading frames in reference to cell signaling and neurological development

Phage composition of a fermented milk and colostrum product assessed by microbiome array; putative role of open reading frames in reference to cell signaling and neurological development

The clinical benefit of hyperthermia in pancreatic cancer: a systematic review

Thermal Therapy Approaches for Treatment of Brain Tumors in Animals and Humans

Contact Info

Product

Resources

About