Tart Cherry Intake Reduces Indices of Metabolic Syndrome in Rats

Seymour, Eric; Singer, A; Kirakosyan, Ara; Urcuyo-Llanes, Daniel E.; Kaufman, Peter B.; Bolling, S. F.

doi:10.17660/actahortic.2009.841.25

Cited by 3 publications

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“…This observation is further supported by findings presented in rodents susceptible to dyslipidaemia responding significantly better to cherry consumption than those without dyslipidaemia Seymour et al, 2008;Wu et al, 2006). The molecular mechanisms associated with these responses were suggested to be via increased mRNA transcription of peroxisome proliferator-activated receptor alpha (PPARα), peroxisome proliferator-activated receptor gamma (PPARγ) and hepatic activation of these isoforms by cherry anthocyanins Seymour et al, 2008). Thus enhancing skeletal muscle insulin sensitisation due to increased fat oxidation through sirtuin-1 mediated PPARα and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) activation (Huffman, 2010).…”

Section: Discussionsupporting

confidence: 82%

“…Despite the addition of an exercise intervention, a similar reasoning can be applied to the present study, given the healthy baseline lipid concentrations presented by the participants in this study. This observation is further supported by findings presented in rodents susceptible to dyslipidaemia responding significantly better to cherry consumption than those without dyslipidaemia Seymour et al, 2008;Wu et al, 2006). The molecular mechanisms associated with these responses were suggested to be via increased mRNA transcription of peroxisome proliferator-activated receptor alpha (PPARα), peroxisome proliferator-activated receptor gamma (PPARγ) and hepatic activation of these isoforms by cherry anthocyanins Seymour et al, 2008).…”

Section: Discussionmentioning

confidence: 53%

“…These phytochemicals are thought to contribute to effectively combating oxidative stress, inflammation and repairing muscle damage post-exercise (Bell, Walshe, Davison, Stevenson, & Howatson, 2014b;Bell, Walshe, Davison, Stevenson, & Howatson, 2015). In rodents, tart cherries have shown significant improvements at the molecular, cellular and systemic level predominantly due to modulation of peroxisome proliferator-activated receptor (PPAR) signalling pathways Seymour et al, 2008). Consequently, percentage fat mass, hyperinsulinaemia, hyperlipidaemia and inflammation were all reduced Seymour et al, 2008).…”

mentioning

confidence: 99%

“…In rodents, tart cherries have shown significant improvements at the molecular, cellular and systemic level predominantly due to modulation of peroxisome proliferator-activated receptor (PPAR) signalling pathways Seymour et al, 2008). Consequently, percentage fat mass, hyperinsulinaemia, hyperlipidaemia and inflammation were all reduced Seymour et al, 2008). Observations in humans have been more equivocal, with tart cherry supplementation showing no effect on blood pressure and bloodbased cardio-metabolic markers in healthy participants (Lynn et al, 2014).…”

mentioning

confidence: 99%

“…Rationale for the present study is based on previous work demonstrating the benefits of anthocyanin supplementation on fat oxidation rates during exercise (Cook, Myers, Gault, Edwards, & Willems, 2017;Cook, Myers, Blacker, & Willems, 2015) and the positive results regarding the effects of tart cherry supplementation against cardio-metabolic dysfunction in rodents Seymour et al, 2008) and humans (Ataie-Jafari, 2008; Keane et al, 2016a;Keane et al, 2016b;Martin et al, 2010). However, to date, no research has explored the cardio-metabolic responses to tart cherry supplementation and exercise in tandem, thus healthy participants were recruited to assess for any adverse effects prior to investigating responses in clinical populations.…”

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confidence: 99%

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The effects of Montmorency tart cherry juice supplementation and FATMAX exercise on fat oxidation rates and cardio-metabolic markers in healthy humans

2018

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Montmorency tart cherries (Prunus cerasus L.) are rich in anthocyanins, compounds capable of augmenting fat oxidation and regulating metabolic dysfunction. The present study examined whether Montmorency tart cherry juice (MTCJ) supplementation could augment fat oxidation rates at rest and during FATMAX exercise, thus improve cardio-metabolic health. Eleven, healthy participants consumed MTCJ or placebo (PLA) twice daily, in a randomised, counterbalanced order for 20 days. Participants cycled at FATMAX for 1-h pre-, mid- (10 days) and post-supplementation whilst substrate oxidation rates were measured. Before exercise anthropometrics and resting metabolic rate were measured. Blood pressure, serum triglycerides, cholesterol, HDL, total antioxidant status (TAS) and glucose were measured immediately before and after exercise. No significant differences between conditions or interactions were observed for any functional and blood-based cardio-metabolic markers or fat oxidation during exercise or rest (P > 0.05). Pre-exercise TAS (P = 0.036) and HDL (P = 0.001) were significantly reduced from mid- to post-supplementation with MTCJ only. Twenty days' MTCJ supplementation had no effect on fat oxidation; therefore, it is unnecessary for individuals in this participant cohort to consume MTCJ with exercise to improve cardio-metabolic biomarkers.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 53%

mentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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The effects of Montmorency tart cherry juice supplementation and FATMAX exercise on fat oxidation rates and cardio-metabolic markers in healthy humans

2018

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The effect of genotype and drying condition on the bioactive compounds of sour cherry pomace

Ciccoritti

Paliotta

Centioni

et al. 2017

Eur Food Res Technol

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Sour cherry (Prunus cerasus L.) contains substantial quantities of phenolic compounds, specifically anthocyanins, and is mainly processed into different products including juice, whose by-product, namely sour cherry pomace (SCP), represents a potential source of high-added bioactive compounds currently underutilized. Oven-drying (OD) and freeze-drying (FD) are simple methods, often used to stabilize food matrices, and can be also successfully employed for the stabilization of sour cherry pomace. In the present study, the influence of genotype (Bianchi d'Offagna and Montmorency cvs), drying method and their interaction on the extractability of phenolic and anthocyanin profiles of sour cherry pomace were evaluated. Both genotype and drying method significantly influenced (p ≤ 0.001) the overall phytochemical content (total monomeric anthocyanin, total flavan-3-ol, total phenolic, and vitamin C) of analysed pomaces. The interrelationships between the parameters analyzed, the genotype, and the different drying conditions, as well as the relationships among variables, were investigated by principal component analysis (PCA). PCA results pointed out that the phytochemical content of sour cherry pomace was firstly influenced by the cultivar (which accounted for about 70% of the total variance), followed by drying process (about 18% of the total variance), and their interaction (about 12% of the total variance), with the exception of total flavan-3-ols, where a similar contribution (about 50%) of the two factors was observed. Besides, antidiabetic potential of SCPs was also investigated, pointing Bianchi D'Offagna FD pomace as the most active. Obtained results 2 point out the SCP stabilized by means of freeze-drying process as a valuable second-generation biorefinery for the food supplements, nutraceutical and pharmaceutical markets.

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Study the Biological and Biochemical Effects of Some Dried Fruits on Acute Renal Failure in Rats

Ali

Yasen

Temraz

2019

Egyptian Journal of Nutrition and Health

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Golden berry and sweet cherry are known as nutritious fruit and herbal medicine for healthpromoting properties. This study was conducted to investigate the effect of golden berry and sweet cherry on acute renal failure in rats induced by glycerol.Thirty six male albino adult rats (150±10 g.) were used, divided into two main groups; one (6 rats each) was used as a negative control group, while the other group of rats were injected intramuscularly with glycerol 10 ml/kg BW (50% v/v in sterile saline 0.9 %) to induce acute renal failure. The second main group was divided into 5 equal subgroups ; one used as a positive control and the other four groups were fed on supplemented diet (5 % and 10 %) of each of dried golden berry and sweet cherry.Biological evaluation, liver enzymes, kidney functions, Na, K and serum antioxidant markers were estimated at the end of the experiment. The results indicated that kidney and liver functions were restored significantly in groups of rats which received golden berry and sweet cherry 10%, followed by golden berry and sweet cherry 5 % as compared to the positive control group. Glycerol rats group showed significant decrease in serum proteins and serum electrolytes. On the other hand, all supplemented groups with golden berry and sweet cherry showed a gradual significant increase in the mentioned parameters. Therefore, this study reveals the benefits of golden berry and sweet cherry in experimental animals with kidney and liver disease. Key words: Acute renal failureglycerolgolden berry and sweet cherry. total phenolic content (TPC) has been reported both in sweet and sour cherries(Serradilla et al., 2016). Glycerol injection caused histopathological changes such as renal tubular injury and renal tubular myoglobin deposition. Levels of N.-(hexanoyl) lysine-modified, 4-hydroxyl-2 nonenalmodified and nitrotyrosine-modified proteins in rat kidneys were unaltered at 1 hour after glycerol injection induced acute kidney injury (Akina et al., 2016). Objective of the study This study was carried out to investigate the effect of golden berry and sweet cherry on acute renal failure induced by glycerol in rats. Materials and Methods Materials: Golden berry and sweet cherry were obtained from local market, Tanta City El-Gharbia Governorate., Egypt. Glycerol, Casein, minerals, vitamins, and cellulose were obtained from El-Faroniah (Chemicals Company), Tanta, Egypt. Thirty six male albino rats (Sprague Dawely) Strain) were purchased from the laboratory animal house of faculty of science, Tanta University, Egypt. Methods: Dehydration: Golden berry and sweet cherry were picked gently washed, carefully drained, dried in the oven at 50°C for 24 hr., crushed and stored in labeled polyethylene bags until analysis. Nutritional Characteristics Chemical Composition: Golden berry and sweet cherry were chemically analyzed for moisture, fat, crude protein, crude fiber, and ash, according to methods of (A.O.A.C., 2000). Total carbohydrates were estimated by difference. Whereas, the energy was calculated by the...

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Tart Cherry Intake Reduces Indices of Metabolic Syndrome in Rats

Cited by 3 publications

References 0 publications

The effects of Montmorency tart cherry juice supplementation and FATMAX exercise on fat oxidation rates and cardio-metabolic markers in healthy humans

The effects of Montmorency tart cherry juice supplementation and FATMAX exercise on fat oxidation rates and cardio-metabolic markers in healthy humans

The effect of genotype and drying condition on the bioactive compounds of sour cherry pomace

Study the Biological and Biochemical Effects of Some Dried Fruits on Acute Renal Failure in Rats

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