Tear Film Thickness After Treatment With Artificial Tears in Patients With Moderate Dry Eye Disease

Abstract

The findings of this study indicate that single instillation of TH-SH and HA eye drops increases TFT in patients with dry eye disease. The data also indicate longer corneal residence of the TH-containing eye drops. The effect of multiple instillation and long-term use of artificial tears on TFT warrants further investigation.

Effect of Topically Administered Chitosan-N-acetylcysteine on Corneal Wound Healing in a Rabbit Model

“…The technical details of this device have been described in detail previously [14]. We have used this system in several human studies to assess precorneal tear film thickness [14, 30–32] as well as to measure corneal wound healing in humans (Bata et al 2016 JAMA Ophthalmology, in press). The latter study shows that in humans, there is a good correlation between corneal wound size measured with OCT and measurements based on corneal fluorescein staining [17].…”

Semiautomated SD-OCT Measurements of Corneal Sublayer Thickness in Normal and Post-SMILE Eyes

“…19 Therefore, the use of lacrimal substitutes or other topical eye medications was prohibited during a period of 4 hours before scanning in an effort to minimize their effect on ET readings. Furthermore, all participants' OCT scans were scheduled after 12:00 PM to reduce the influence of diurnal variations of ET and ST. 20…”

Effect of different lubricant eye gels on tear film thickness as measured with ultrahigh‐resolution optical coherence tomography

“…For quantification of TFT, we used a custom-built ultrahigh-resolution optical coherence tomography (OCT) system, which has previously been used to characterize effects of topical lubricants (Kaya et al 2015;Schmidl et al 2015a). For quantification of TFT, we used a custom-built ultrahigh-resolution optical coherence tomography (OCT) system, which has previously been used to characterize effects of topical lubricants (Kaya et al 2015;Schmidl et al 2015a).…”

“…In this study, we compared the changes in precorneal tear film thickness (TFT) after administration of three commercially available gel-based lubricants indicated for DED. For quantification of TFT, we used a custom-built ultrahigh-resolution optical coherence tomography (OCT) system, which has previously been used to characterize effects of topical lubricants (Kaya et al 2015;Schmidl et al 2015a). Measurement of TFT was performed to get insight into the residence time of the lubricants on the ocular surface after single-drop administration.…”