Technical hints for high dose rate interstitial tongue brachytherapy

Leung, TW; Wong, Victy Y. W.; Wong, Chow-Ming; Tung, Stewart Y.; Tsang, Acc; Lowes, M.; Au, Minkin; Chan, Claudia; Sze, W.M.; Leung, L. C.

doi:10.1016/s0936-6555(98)80006-x

Cited by 22 publications

(14 citation statements)

References 7 publications

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“…Various authors have demonstrated local control rates ranging from 90 to 100% by using equivalent doses from 65 to 80 Gy in oral cavity tumors [28,29,30]. In our insti-For T2 stage, the 5 year NCR were higher in the combined EBRT and brachytherapy group compared to brachytherapy alone group (92.9% vs. 74.3%) but the results could not achieve statistical significance.…”

Section: Discussioncontrasting

confidence: 67%

High-dose-rate interstitial brachytherapy in early stage oral tongue cancer – 15 year experience from a tertiary care institute

Bansal¹,

Ghoshal²,

Oinam³

et al. 2016

jcb

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Purpose: To determine outcomes of interstitial high-dose-rate brachytherapy (HDR-BT) in patients with early stage oral tongue cancer.Material and methods: Ninety-two patients with stage I and II oral tongue cancer were treated with HDR-BT between 1999 and 2014: brachytherapy alone = 62 (67.4%), and combination of external beam radiotherapy (EBRT) and brachytherapy = 30 (32.6%). Median follow-up was 53.5 months. Patterns of failure, overall survival (OS), disease-free survival (DFS), local control rates (LCR), and nodal control rates (NCR) were determined.Results: 5-year OS, DFS, LCR, and NCR were 73.2%, 58.2%, 64.2%, and 83.8%, respectively. In total, 43 patients (46.7%) failed treatment: isolated local failures = 28 (30.4%), isolated nodal failures = 8 (8.7%), both local and regional failures = 7 (7.6%). While in T1 stage, 5 year LCR were significantly higher in brachytherapy alone group compared to combined EBRT and brachytherapy group (81.7% vs. 62.5%, p = 0.04), the isolated nodal failure rates were not significantly different among the two groups. For T2 stage, NCR were higher in combined EBRT and brachytherapy group compared to brachytherapy alone (92.9% vs. 74.3%). Acute mucositis (grade ≥ 2) was seen more in brachytherapy alone group compared to the combined modality group (87% vs. 66%), and this correlated significantly with the higher biological equivalent dose (BED) in the brachytherapy alone group.Conclusions: Our study recommends treating patients with brachytherapy alone in T1 stage, and demonstrates the need for addressing nodal region either by neck dissection or nodal irradiation in T2 stage patients. Also, the study highlights the need for dose escalation (from the doses used in the study) in both T1 and T2 stage tumors when using interstitial brachytherapy either as sole modality or as a boost.

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Section: Discussioncontrasting

confidence: 67%

High-dose-rate interstitial brachytherapy in early stage oral tongue cancer – 15 year experience from a tertiary care institute

Bansal¹,

Ghoshal²,

Oinam³

et al. 2016

jcb

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“…In the later part of the study, a comb rake dose distribution technique was implemented to better cover the implant tracts. 10 An analysis of the treatment result was undertaken 1 year after the commencement of the program. There was no local failure for the six consecutively treated patients, and they experienced quite a long period of mucositis, with a median time of 12 weeks (range, 6À20 weeks).…”

Section: Discussionmentioning

confidence: 99%

“…The technique of insertion has been described in a previous publication. 10 The afterloading catheters were positioned with the patient under general anesthesia using the submandibular approach with the assistance of homemade template sets. The size of the tumor was measured, and a stainless steel marker was implanted to mark the inferior border of the tumor.…”

Section: Methodsmentioning

confidence: 99%

High dose rate brachytherapy for early stage oral tongue cancer

et al. 2002

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“…The borders of the dummy mandibular shields were marked by lead wires in such a way that the fit and coverage could be verified by check films (Figures 1 and 2). The technique of insertion has been described in a previous publication 10. The afterloading catheters were positioned with the patient under general anesthesia using the submandibular approach with the assistance \of homemade template sets.…”

Section: Methodsmentioning

confidence: 99%

Treatment of High Strength Distillery Wastewater (Cherry Stillage) by Integrated Aerobic Biological Oxidation and Ozonation

Beltrán

Álvarez

Rodrı́guez

et al. 2001

Biotechnology Progress

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The performance of integrated aerobic digestion and ozonation for the treatment of high strength distillery wastewater (i.e., cherry stillage) is reported. Experiments were conducted in laboratory batch systems operating in draw and fill mode. For the biological step, activated sludge from a municipal wastewater treatment facility was used as inoculum, showing a high degree of activity to distillery wastewater. Thus, BOD and COD overall conversions of 95% and 82% were achieved, respectively. However, polyphenol content and absorbance at 254 nm (A(254)) could not be reduced more than 35% and 15%, respectively, by means of single biological oxidation. By considering COD as substrate, the aerobic digestion process followed a Contois' model kinetics, from which the maximum specific growth rate of microorganisms (mu(max)) and the inhibition factor, beta, were then evaluated at different conditions of temperature and pH. In the combined process, the effect of a post-ozonation stage was studied. The main goals achieved by the ozonation step were the removal of polyphenols and A(254). Therefore, ozonation was shown to be an appropriate technology to aid aerobic biological oxidation in the treatment of cherry stillage.

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Technical hints for high dose rate interstitial tongue brachytherapy

Cited by 22 publications

References 7 publications

High-dose-rate interstitial brachytherapy in early stage oral tongue cancer – 15 year experience from a tertiary care institute

High-dose-rate interstitial brachytherapy in early stage oral tongue cancer – 15 year experience from a tertiary care institute

High dose rate brachytherapy for early stage oral tongue cancer

Treatment of High Strength Distillery Wastewater (Cherry Stillage) by Integrated Aerobic Biological Oxidation and Ozonation

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