Television Viewing Is Associated With Prevalence of Metabolic Syndrome in Hispanic Elders

Gao, Xiang; Nelson, Miriam E.; Tucker, Katherine L.

doi:10.2337/dc06-1835

Cited by 71 publications

(85 citation statements)

References 35 publications

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“…Four of the seven cross-sectional studies found statistically significant, positive associations between sedentary behavior and metabolic biomarkers. Positive associations were observed with insulin (52), insulin resistance (101,105), and 2-hour glucose (108), but not with fasting plasma glucose (17,84,108) or insulinlike growth factors (109). Inflammation.…”

Section: Biological Pathwaysmentioning

confidence: 96%

Sedentary Behavior and Cancer: A Systematic Review of the Literature and Proposed Biological Mechanisms

Lynch

2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

319

286

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Background: Sedentary behavior (prolonged sitting or reclining characterized by low energy expenditure) is associated with adverse cardiometabolic profiles and premature cardiovascular mortality. Less is known for cancer risk. The purpose of this review is to evaluate the research on sedentary behavior and cancer, to summarize possible biological pathways that may underlie these associations, and to propose an agenda for future research.Methods: Articles pertaining to sedentary behavior and (a) cancer outcomes and (b) mechanisms that may underlie the associations between sedentary behavior and cancer were retrieved using Ovid and Web of Science databases.Results: The literature review identified 18 articles pertaining to sedentary behavior and cancer risk, or to sedentary behavior and health outcomes in cancer survivors. Ten of these studies found statistically significant, positive associations between sedentary behavior and cancer outcomes. Sedentary behavior was associated with increased colorectal, endometrial, ovarian, and prostate cancer risk; cancer mortality in women; and weight gain in colorectal cancer survivors. The review of the literature on sedentary behavior and biological pathways supported the hypothesized role of adiposity and metabolic dysfunction as mechanisms operant in the association between sedentary behavior and cancer.Conclusions: Sedentary behavior is ubiquitous in contemporary society; its role in relation to cancer risk should be a research priority. Improving conceptualization and measurement of sedentary behavior is necessary to enhance validity of future work.Impact: Reducing sedentary behavior may be a viable new cancer control strategy. Cancer Epidemiol Biomarkers

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Section: Biological Pathwaysmentioning

confidence: 96%

Sedentary Behavior and Cancer: A Systematic Review of the Literature and Proposed Biological Mechanisms

Lynch

2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

319

286

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“…The second tenet of inactivity physiology is that the various times that people spend sitting or participating in exercise-based leisure-time physical activity are distinct classes of behavior, with distinct determinants (5) and independent effects on risk for disease (19,20,(23)(24)(25)(26). The third, and central, tenet for the paradigm of inactivity physiology is that some of the specific cellular and molecular processes explaining the responses during inactivity physiology versus exercise physiology are qualitatively different from each other.…”

Section: Paradigm Of Inactivity Physiologymentioning

confidence: 99%

“…Metabolic syndrome is a constellation of risk factors for CVD and type 2 diabetes, including plasma triglycerides, HDL cholesterol, plasma glucose, blood pressure, and central adiposity or waist girth. Studies have shown that the classification of people with metabolic syndrome (19,(23)(24)(25) and related metabolic risk factors (31,(35)(36)(37)(38)(39)(40), excessive adiposity or weight gain (5,15,(41)(42)(43)(44)(45)(46), poor glucose management in children with type 1 diabetes (47), and type 2 diabetes risk (20,26,35) have all been directly related to sitting time and/or inversely to low nonexercise activity. Estimations from prolonged TV and computer time led to the conclusion that too much sitting can more than double the risk for metabolic syndrome (19,23,24).…”

Section: A New Concern For Future Public Health Problems?mentioning

confidence: 99%

Role of Low Energy Expenditure and Sitting in Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease

2007

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It is not uncommon for people to spend one-half of their waking day sitting, with relatively idle muscles. The other half of the day includes the often large volume of nonexercise physical activity. Given the increasing pace of technological change in domestic, community, and workplace environments, modern humans may still not have reached the historical pinnacle of physical inactivity, even in cohorts where people already do not perform exercise. Our purpose here is to examine the role of sedentary behaviors, especially sitting, on mortality, cardiovascular disease, type 2 diabetes, metabolic syndrome risk factors, and obesity. Recent observational epidemiological studies strongly suggest that daily sitting time or low nonexercise activity levels may have a significant direct relationship with each of these medical concerns. There is now a need for studies to differentiate between the potentially unique molecular, physiologic, and clinical effects of too much sitting (inactivity physiology) separate from the responses caused by structured exercise (exercise physiology). In theory, this may be in part because nonexercise activity thermogenesis is generally a much greater component of total energy expenditure than exercise or because any type of brief, yet frequent, muscular contraction throughout the day may be necessary to short-circuit unhealthy molecular signals causing metabolic diseases. One of the first series of controlled laboratory studies providing translational evidence for a molecular reason to maintain high levels of daily low-intensity and intermittent activity came from examinations of the cellular regulation of skeletal muscle lipoprotein lipase (LPL) (a protein important for controlling plasma triglyceride catabolism, HDL cholesterol, and other metabolic risk factors). Experimentally reducing normal spontaneous standing and ambulatory time had a much greater effect on LPL regulation than adding vigorous exercise training on top of the normal level of nonexercise activity. Those studies also found that inactivity initiated unique cellular processes that were qualitatively different from the exercise responses. In summary, there is an emergence of inactivity physiology studies. These are beginning to raise a new concern with potentially major clinical and public health significance: the average nonexercising person may become even more metabolically unfit in the coming years if they sit too much, thereby limiting the normally high volume of intermittent nonexercise physical activity in everyday life. Thus, if the inactivity physiology paradigm is proven to be true, the dire concern for the future may rest with growing numbers of people unaware of the potential insidious dangers of sitting too much and who are not taking advantage of the benefits of maintaining nonexercise activity throughout much of the day. Diabetes 56:2655-2667, 2007 H umans have been increasingly spending more time in sedentary behaviors involving prolonged sitting. This global trend is likely to continue, given the increasing ...

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“…Although several observational studies in seniors have implicated increased sedentary time with elevated risk of having the metabolic syndrome [6,7], most well-conducted studies have focused nearly exclusively on younger individuals. is is despite the fact that seniors are the most sedentary group of all; older adults have been found to reach their exercise targets only 0 to 4.9 percent of the time [4,5].…”

Section: Discussionmentioning

confidence: 99%

“…Cross sectional survey based studies have associated less activity with adverse metabolic parameters [6,7]. Because most older adults do not meet current guidelines for physical activity [8], it is di cult to discern whether it is a lack of exercise, excessive sedentary behaviour, or both that leads to metabolic risk.…”

mentioning

confidence: 99%

Accelerometer-based measures of sedentary behavior and cardio-metabolic risk in active older adults

Chase¹,

Lockhart²,

Ashe³

et al. 2014

CIM

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Accelerometer-based measures of sedentary behavior and cardiometabolic risk in active older adults Abstract Purpose: Sedentary behavior has been proposed as an independent cardio-metabolic risk factor even in adults who are physically active through recreational activity. Because little is known about the metabolic e ects of sedentariness in seniors, the relationship between sedentary behavior and cardio-metabolic risk was examined in physically active older adults.Methods: Fi y-four community dwelling men and women > 65 years of age (mean 71.5 years) were enrolled in this cross-sectional observational study. Subjects were in good health and free of known diabetes. Activity levels (sedentary, light, moderate to vigorous activity time per day) were recorded with accelerometers worn continuously for 7 days. Cardio-metabolic risk factors measured consisted of the American Heart Association diagnostic criteria for metabolic syndrome (waist circumference, triglycerides, high-density lipoprotein, systolic blood pressure and fasting glucose) as well as low-density lipoprotein (LDL). e relationships between activity measures and cardio-metabolic risk factors were examined. Signi cant variables were then entered into a stepwise multivariate regression model.Results: All but one subject achieved exercise levels recommended by the American College of Sports Medicine. e average proportion of time spent at a sedentary activity level each day was 72.7%. From the regression analysis, the only signi cant association found between cardio-metabolic risk outcomes and activity predictors was between LDL and sedentary time, with LDL detrimentally associated with average sedentary time per day (Standardized Beta Correlation Coe cient 0.302, p< 0.05).Conclusion: Sedentary behavior is associated with an adverse metabolic e ect on LDL in seniors, even those who meet guideline recommendations for an active " t" adult.

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Television Viewing Is Associated With Prevalence of Metabolic Syndrome in Hispanic Elders

Cited by 71 publications

References 35 publications

Sedentary Behavior and Cancer: A Systematic Review of the Literature and Proposed Biological Mechanisms

Sedentary Behavior and Cancer: A Systematic Review of the Literature and Proposed Biological Mechanisms

Role of Low Energy Expenditure and Sitting in Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease

Accelerometer-based measures of sedentary behavior and cardio-metabolic risk in active older adults

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