Telocytes in female reproductive system (human and animal)

Aleksandrovych, Veronika; Walocha, Jerzy; Gil, Krzysztof

doi:10.1111/jcmm.12843

Cited by 44 publications

(53 citation statements)

References 44 publications

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“…1 The quantity of TCs in the endometrium and the myometrium correlates with the reproductive state. 40 Immature rat uteruses present the lowest density of TCs compared to pregnant and postpartum ones. 41 The number of endometrial TCs in pregnant state increases, while there is a reduction of their number in the myometrium.…”

Section: Telocytes In Uterusmentioning

confidence: 95%

“…41 The number of endometrial TCs in pregnant state increases, while there is a reduction of their number in the myometrium. 40 Hence, changes in the quantity of TCs in the myometrium may be associated with the prevention of preterm delivery. 25 Moreover, the highest number of myometrial TCs were found in the postpartum uteri, which may be related with its involution.…”

Section: Telocytes In Uterusmentioning

confidence: 99%

“…25 Moreover, the highest number of myometrial TCs were found in the postpartum uteri, which may be related with its involution. 40 Additionally, the morphology of Tps is different in pregnant and non-pregnant myometrium -in non-pregnant uterus podomers are wider and podoms are thinner compared to pregnant ones (Table 1). 31 The most useful markers used for the identification of TCs in the uterus are CD34 and PDGFR-α/PDGFR-β in double immunolabelling.…”

Section: Telocytes In Uterusmentioning

confidence: 99%

“…53 The declined quantity of TCs, which is probably caused by the overproduction of iNOS, COX-2, LPO and estradiol, damages those cells and were also observed in pelvic endometriosis and tubal ectopic pregnancy. 40,42,54 Nevertheless, TCs of nearly normal appearance can be found even in endometriosis-affected uterine tube. Presumably, that is the reason why some women in this state have only reduced fertility instead of complete infertility.…”

Section: Telocytes In Uterine Tubesmentioning

confidence: 99%

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Telocytes in the female reproductive system: An overview of up-to-date knowledge

Janas¹,

Kucybała²,

Radoń-Pokracka³

et al. 2018

Adv Clin Exp Med

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Telocytes are emerging cell population localized in the stroma of numerous organs, characterized by a distinctive morphology - small cell body with very long, slender prolongations, termed telopodes. Those cells can be found in the whole female reproductive system: in the vagina, uterus, oviducts and ovaries, mammary glands and also in the placenta. In our review, we aim at complete and transparent revision of the current knowledge of telocytes' localization and function, enriched by the analysis of the possible future direction of development of their clinical applications. The function of telocytes in the reproductive system has not been fully elucidated yet; however, many researchers point at their role in the regulation of local microenvironment, myogenic contractile mechanism, bioelectrical signaling, immunomodulation and regulation of blood flow. Additionally, previous research suggests that telocytes might act as sex hormone level sensors and are connected with pregnancy maintenance. As the morphology and number of those cells change under pathological conditions, such as pre-eclampsia, endometriosis and ovarian failure, there is a chance that they may contribute to therapy of abovementioned conditions. The impact of telocytes on stem cells and angiogenesis has been proven in many organs, and may be useful in regenerative medicine of the female reproductive system. A recently found connection between the proliferation rate of breast cancer cells and stromal cells like telocytes might be a step forward to the management of mammary gland neoplasms.

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Section: Telocytes In Uterusmentioning

confidence: 95%

Section: Telocytes In Uterusmentioning

confidence: 99%

Section: Telocytes In Uterusmentioning

confidence: 99%

Section: Telocytes In Uterine Tubesmentioning

confidence: 99%

See 2 more Smart Citations

Telocytes in the female reproductive system: An overview of up-to-date knowledge

Janas¹,

Kucybała²,

Radoń-Pokracka³

et al. 2018

Adv Clin Exp Med

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show abstract

“…Tcs simultaneously belong to interstitial, endothelial, smooth muscle, nerve, mast, and hematopoietic stem cell immunophenotypes. They express CD117, vimentin, CD34, SMA, S100, NSE, as well as the gap junction protein connexin-43 [5,6,7]. Tcs form a 3D network in almost all organs, and they are involved in inflammation, regeneration, and angiogenesis; through multiple diverse cell-to-cell contacts and micro-vesicle involvement, they can coordinate inter-cellular interactions [8,9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Morphological and immunophenotypic characterization of perivascular interstitial cells in human glioma: Telocytes, pericytes, and mixed immunophenotypes

et al. 2020

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Telocytes (Tcs) and pericytes (Pcs) are two types of perivascular interstitial cell known to be widespread in various organs and tissues, including the brain. We postulated that Tcs and Pcs may be involved in glioblastoma (GBM) neovascularization. Objective: Morphological study of Tc and Pc roles in GBM. Materials and Methods: Samples from 15 GBM, 10 diffuse astrocytoma, as well as 5 control samples were studied. We used immunohistochemistry (IHC) with antibodies (Abs) to GFAP, Ki-67, CD117, NeuroD1, NG2, CD34, and SMA. Confocal laser scanning microscopy (CLSM) of 4 glioma tissue cultures and 4 GBM sections was performed with GFAP, CD117, CD34/connexin43, NeuroD1/connexin43, CD34/NG2 and CD13/ CD117 Abs. Electron microscopy (EM) of GBM was performed in 4 cases. Results: The presence of Tcs and Pcs was shown in GBM (IHC, EM, CLSM) and glioma cultures (CLSM). The Tc immunophenotype was CD117 + /CD34 + /connexin43 + / NeuroD1 +. The Pc immunophenotype was SMA + /NG2 + /CD13 +. The number of Tcs in GBM specimens was 10 times higher than in astrocytoma. We also identified CD13/ CD117 and CD34/NG2 co-expressing cells in GBM blood vessels. Conclusion: Four immunophenotypes were found in GBM vessels, corresponding to endotheliocytes, Pcs, Tcs, and a mixed Pc/Tc immunophenotype. These and forthcoming improvements in our understanding of the origin and function of Tcs, including their relationship with Pcs, are necessary steps in oncology. Study of these cell types (Tcs, Pcs) and their roles in brain tumor oncogenesis will likely enable improved targeted therapies and support development of new forms of anti-neoplastic drugs.

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Telocytes of the male urogenital system: Interrelationships, possible functions, and pathological implications

Sanches

Tamarindo

Maldarine

et al. 2021

Cell Biology International

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The male urogenital system is composed of the reproductive system and the urinary tract; they have an interconnected embryonic development and share one of their anatomical components, the urethra. This system has a highly complex physiology deeply interconnected with the circulatory and nervous systems, as well as being capable of adapting to environmental variations; it also undergoes changes with aging and, in the case of the reproductive system, with seasonality.The stroma is an essential component in this physiological plasticity and its complexity has increased with the description in the last decade of a new cell type, the telocyte. Several studies have demonstrated the presence of telocytes in the organs of the male urogenital system and other systems; however, their exact function is not yet known. The present review addresses current knowledge about telocytes in the urogenital system in terms of their locations, interrelationships, possible functions and pathological implications. It has been found that telocytes in the urogenital system possibly have a leading role in stromal tissue organization/maintenance, in addition to participation in stem cell niches and an association with the immune system, as well as specific functions in the urogenital system, lipid synthesis in the testes, erythropoiesis in the kidneys and the micturition reflex in the bladder. There is also evidence that telocytes are involved in pathologies in the kidneys, urethra, bladder, prostate, and testes.

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Telocytes in female reproductive system (human and animal)

Cited by 44 publications

References 44 publications

Telocytes in the female reproductive system: An overview of up-to-date knowledge

Telocytes in the female reproductive system: An overview of up-to-date knowledge

Morphological and immunophenotypic characterization of perivascular interstitial cells in human glioma: Telocytes, pericytes, and mixed immunophenotypes

Telocytes of the male urogenital system: Interrelationships, possible functions, and pathological implications

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