Telomerase activity and its association with psychological stress, mental disorders, lifestyle factors and interventions: A systematic review

Deng, Wen; Cheung, Denise Shuk Ting; Tsao, Sai‐Wah; Wang, X.M.; Tiwari, Agnes

doi:10.1016/j.psyneuen.2015.11.017

Cited by 56 publications

(53 citation statements)

References 132 publications

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“…Previous narrative reviews have reported a positive association between diet and telomere length; however, this is the first meta-analysis that evaluated the influence of diet on telomere length [28]. A recent systematic review [29] analyzed telomerase activity in association with psychological stress, mental disorders, and lifestyle interventions. Among lifestyle interventions, the micronutrient supplementation diet was analyzed, and telomerase activity was found to be increased in individuals who did not have any other lifestyle intervention.…”

Section: Discussionmentioning

confidence: 99%

Effects of Diet on Telomere Length: Systematic Review and Meta-Analysis

Pérez

Amaral

Mundstock

et al. 2017

Public Health Genomics

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Background: The goal of this systematic review and meta-analysis is to determine the effect of diet on telomere length. Methods: We searched the following databases: MEDLINE, Embase, LILACS, CINAHL, ISI Web of Science, and Scopus, as well as the Cochrane Central Register of Controlled Trials and the National Institutes of Health, from inception to December 2016. Articles that assessed effects of diet on telomere length were included. Results: A total of 2,128 studies were identified, 30 were read in full, and 7 were systematically reviewed. Five RCTs were included in the meta-analysis, covering 9 diets; a total of 533 participants were included. Study heterogeneity (I²) was 89%, and differences were not identified regarding average telomere lengths (mean difference 1.06; 95% CI –1.53 to 3.65). Conclusion: The available evidence suggests that there is no effect of diet on telomere length, but the strong heterogeneity in the type and duration of dietary interventions does not allow any final statement on the absence of an effect of diet on telomere length.

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Section: Discussionmentioning

confidence: 99%

Effects of Diet on Telomere Length: Systematic Review and Meta-Analysis

Pérez

Amaral

Mundstock

et al. 2017

Public Health Genomics

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“…). The dysfunctional hippocampal neural plasticity is usually associated with neurological disorders including Alzheimer disease, depression, anxiety, and schizophrenia (de Flores et al, ; Schuch et al, ; Deng et al, ). So, it also will be worthwhile to deeply explore the alteration of antidepressant behaviors affected by excessive physical training in the future.…”

Section: Discussionmentioning

confidence: 99%

High‐intensity treadmill running impairs cognitive behavior and hippocampal synaptic plasticity of rats via activation of inflammatory response

Sun

Wang

et al. 2016

J of Neuroscience Research

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Although appropriate exercise is beneficial for enhancing brain functions, high-intensity exercise (HIE)-induced cognitive dysfunction is causing more and more concerns nowadays. In the present study, we observed the effects of high-intensity treadmill running on the spatial learning of the adult Sprague Dawley male rats in Y-maze (n = 16 per group), and investigated its possible electrophysiological and molecular mechanisms by examining in vivo hippocampal long-term potentiation (LTP), central inflammatory responses, and JNK/p38/ERK signal pathway. The Y-maze active avoidance test showed that high-intensity treadmill running impaired spatial learning ability of rats, with increased error times and prolonged training time in recognizing safety condition. Associated with the cognitive dysfunction, the induction and maintenance of hippocampal LTP were also impaired by the HIE. Furthermore, accompanied by elevated levels of inflammatory factors IL-1β, TNF-α, and iNOS, overactivation of microglia and astrocytes was also found in the CA1 region of hippocampus in the excessive exercise group, indicating an inflammatory response induced by HIE. In addition, Western blot assay showed that the phosphorylation of JNK/p38/ERK proteins was enhanced in the exercise group. These results suggest that exercise stress-induced neuronal inflammatory responses in the hippocampus are associated with HIE-induced cognitive deficits, which may be involved in the upregulation of the JNK/p38/ERK pathway. © 2016 Wiley Periodicals, Inc.

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“…At the same time, a combination of short telomeres and high telomerase activity has been shown to be associated with various risk factors, including chronic psychological stress (Zalli et al, 2014). Based on these results, a new concept of stress response was recently formulated: it can either bring about a decrease in telomerase activity, leading to a shortening of telomeres, or an increase in telomerase activity, allowing it to maintain or even to increase the telomere length (Beery et al, 2012; for a constructive review, see Deng et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Influence of music therapy on the telomere length: a brief review and a pilot study

Spivak¹,

Смирнова²,

Urazova³

et al. 2019

biologija

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Relation between music perception and telomere length is discussed. Telomeres are now considered as markers of general health and as possible predictor of life expectancy, while their length correlates with either the risk of age-related pathologies or with higher adaptive performance. The ability to withstand agerelated telomere shortening by means of practicing psychological training is discussed. Problems and prospects of present-day music therapy are reviewed, as well as absence of studies of alteration of telomere length, related to music perception. Sixty-three practically healthy young (aged 24 ± 5 years) randomly selected Russian-speaking students were divided into three subgroups, each of which listened to music of a specific type for 14 days, 90 minutes each day. Before and after the two-week course, the telomere length and telomerase activity in blood samples were measured. A limited but statistically reliable increase in the telomere length and in telomerase activity is demonstrated to have occurred as a result of completing the music course. Classical music tends to bring about less stress, positively affect one’s mood, and physiology, and, finally, such essential aging markers as telomerase activity and the telomere length. Non-classical music conditioned manifestation of some stress, which tended to affect the telomere length in a negative way. In order to cope with this difficulty, telomerase was activated.

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Telomerase activity and its association with psychological stress, mental disorders, lifestyle factors and interventions: A systematic review

Cited by 56 publications

References 132 publications

Effects of Diet on Telomere Length: Systematic Review and Meta-Analysis

Effects of Diet on Telomere Length: Systematic Review and Meta-Analysis

High‐intensity treadmill running impairs cognitive behavior and hippocampal synaptic plasticity of rats via activation of inflammatory response

Influence of music therapy on the telomere length: a brief review and a pilot study

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