Telomere shortening and frailty in Mexican older adults

Ortiz-Ramírez, Mauricio; Sánchez-García, Sergio; Torre, Paola; Reyes‐Maldonado, Elba; Sánchez-Arenas, Rosalinda; Rosas-Vargas, Haydeé

doi:10.1111/ggi.13463

Cited by 12 publications

(9 citation statements)

References 27 publications

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“…A first analysis was conducted to determine our hypothesized distinct distributions between oxidative stress, lipid peroxidation, and telomere length according to frailty groups; however, we observed a significantly different distribution only for telomere length. Telomere length was found to be associated with pre-frail and frail categories, as previously reported 12 . This specific variable has become of importance for older adults since, despite the philosophical debate about the definition of frailty, it has shown to have a predictive Figure 2.…”

Section: Discussionsupporting

confidence: 86%

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Oxidative Stress, Telomere Length, and Frailty in an Old Age Population

Martínez‐Ezquerro

Rodríguez-Castañeda

Ortiz-Ramírez

et al. 2020

RIC

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Background: A global aging population requires focusing on the risk factors for unhealthy aging, preventive medicine, and chronic disease management. The identification of adverse health outcomes in older adults has been addressed by the characterization of frailty as a biological syndrome. In this field, oxidative stress and telomere length have been suggested as biomarkers of aging. Objective: The objective of the study was to study the association of oxidative stress, telomere length, and frailty in an old age population. Methods: We conducted a cross-sectional study based on 2015 data from 202 members of a cohort of older adults (n = 202; F/M gender ratio: 133/69; mean age: 69.89 ± 7.39 years). Reactive oxygen species were measured by dichlorofluorescein diacetate and lipid peroxidation by malondialdehyde. Telomere length was determined using quantitative polymerase chain reaction with SYBR Green Master Mix. Results: Statistical analysis showed an association between telomere length and frailty but no association between oxidative stress and telomere length or frailty. Conclusions: Telomere length could eventually be used as a marker to differentiate between healthy and unhealthy aging as expressed by frailty phenotype; oxidative stress seemed merely a biological process of aging.

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Section: Discussionsupporting

confidence: 86%

“…On the matter, telomere length, which has been associated with lifespan 9 , has had a controversial role in frailty description. Although no correlation was found for Chinese 10 and German 11 populations, we recently observed shorter telomeres associated with frailty in a Mexican population 12 .…”

Section: Introductioncontrasting

confidence: 68%

Oxidative Stress, Telomere Length, and Frailty in an Old Age Population

Martínez‐Ezquerro

Rodríguez-Castañeda

Ortiz-Ramírez

et al. 2020

RIC

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“…Other markers such as telomere length which has been associated with lifespan (Boonekamp, Simons, Hemerik, & Verhulst, 2013), have had a controversial role on frailty description. Although no correlation was found for Chinese (Yu, Tang, Leung, & Woo, 2015) and German (Breitling et al, 2016) populations, we recently observed shorter telomeres associated with frailty in a Mexican population (Ortiz-Ramírez et al, 2018).…”

Section: Background and Objectivescontrasting

confidence: 56%

Oxidative stress, telomere length, and frailty in an old age population

Martínez‐Ezquerro

Rodríguez-Castañeda

Ortiz-Ramírez

et al. 2018

Preprint

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Background and objectives:A global aging population requires focus on the risk factors for unhealthy aging, preventive medicine, and chronic disease management. The identification of adverse health outcomes in older adults has been addressed by the characterization of frailty as a biological syndrome. On the other hand, oxidative stress and telomere length have been suggested as biomarkers of aging. Here we evaluated the association of oxidative stress, telomere length, and frailty in an old age population. Research design and methods:This was a cross-sectional study based on 2015 data from 202 members from the Cohort of Obesity, Sarcopenia and Frailty of Older Mexican Adults (n=202; gender F/M ratio: 133/69; mean age: 69.89 ± 7.39 years). Reactive oxygen species (ROS) were measured by dichlorofluorescin diacetate, and lipid peroxidation by malondialdehyde. Telomere length was determined using qPCR with SYBR Green Master Mix.

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“…38 Tobacco consumption is the main environmental modifying factor and is associated with telomere length and frailty in older adults. 39 Obesity, smoking, and aging act in concert to accelerate telomere loss.…”

Section: Genetic Factorsmentioning

confidence: 99%

Telomere length and associated factors in older adults with hypertension

Liu

Zhang

2019

J Int Med Res

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Telomeres and telomerase play important roles in the occurrence and development of hypertension. This review was performed to clarify the factors that influence telomere length and telomerase activity in older patients and elucidate the association of these factors with hypertension. A PubMed search and critical review of studies assessing the risk factors underlying the association of hypertension with telomere length and telomerase activity was performed. Telomere length and telomerase activity were found to be associated with hypertension. The factors that influence telomere length and telomerase activity in older patients with hypertension include genetics, demographics, social and environmental factors, chronic disease, psychological factors, and antihypertensive drug treatment. A better understanding of the molecular mechanisms underlying the association of hypertension with telomere length and telomerase activity may help to reduce the incidence of hypertension.

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Telomere shortening and frailty in Mexican older adults

Abstract: Telomere length is inversely related to frailty in Mexican frail older adults, and tobacco consumption is the main environmental modifying factor. Geriatr Gerontol Int 2018; 18: 1286-1292.

Cited by 12 publications

References 27 publications

Oxidative Stress, Telomere Length, and Frailty in an Old Age Population

Oxidative Stress, Telomere Length, and Frailty in an Old Age Population

Oxidative stress, telomere length, and frailty in an old age population

Telomere length and associated factors in older adults with hypertension

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