Temperature-reversible switched antineoplastic drug 5-fluorouracil electrochemical sensor based on adaptable thermo-sensitive microgel encapsulated PEDOT

Mutharani, Bhuvanenthiran; Ranganathan, Palraj; Chen, Shen‐Ming

doi:10.1016/j.snb.2019.127361

Cited by 44 publications

(29 citation statements)

References 50 publications

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“…The unique coil-to-globule transition of PNIPAM chains at the lower critical solution temperature (LCST) (around 35°C) allows the large temperature-responsive volume phase transition of the PNIPAM/CMCS/MWCNT hydrogel and loss of large amount of water. [21] Then, the deswelled hydrogel was immersed into aniline/HCl solution to get the aniline monomers into the pores of the hydrogel until it reswells to original volume which indicated aniline/HCl solution was absorbed. The aniline monomers were immobilized in the PNIPAM/CMCS/MWCNT hydrogel through noncovalent interactions between the active functional groups of the CMCS and MWCNT chains and the hydrogen atoms of the aniline monomers.…”

Section: Preparation Of the Pnipam/cmcs/mwcnt/pani Hydrogelmentioning

confidence: 99%

Conductive PNIPAM/CMCS/MWCNT/PANI hydrogel with temperature, pressure and pH sensitivity

et al. 2021

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In this work, a temperature-sensitive conductive hybrid hydrogel is prepared by in situ polymerization on MWCNT reinforced PNIPAM/CMCS hydrogels. MWCNT and PANI combined the PNIPAM/CMCS matrix with physical and chemical crosslinking that improved the stiffness and elasticity of hydrogel. Due to good mechanical stretchability, high electrical conductivity, thermal responsiveness and pH sensitivity, this hydrogel has potential in the application of wearable devices, temperature sensitive sensor and pH detector. Polymer hydrogels with stimulus-response characteristics with good electrical properties have great potential in electrical, electrochemical, and biomedical devices. Here, a temperaturesensitive conductive hybrid hydrogel is prepared using in-situ polymerized polyaniline (PANI) on PNIPAM/CMCS/MWCNT hydrogel substrate. The network of physical and chemical crosslinking endows the PNIPAM/CMCS/MWCNT/PANI hydrogel with highly porous structures, which greatly enhances the mechanical properties and enhances the stability. The hybrid hydrogel as a strain sensor shows high sensitivity (gauge factor 3.603) and outstanding linear dependence of sensitivity on strain. The hybrid hydrogels can be used to construct highly sensitive temperature alertor based on circuit disconnection caused by volume shrinkage at high temperatures. Moreover, the hybrid hydrogels can also be used as pH sensor to monitor changes of acid and alkali in the solution.

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Section: Preparation Of the Pnipam/cmcs/mwcnt/pani Hydrogelmentioning

confidence: 99%

Conductive PNIPAM/CMCS/MWCNT/PANI hydrogel with temperature, pressure and pH sensitivity

et al. 2021

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“…As shown in Figure E, the absorption bands of 3425 cm −1 and 3288 cm −1 are due to the asymmetric tensile vibration and symmetrical tensile vibration of N−H, respectively. Similarly, the absorption bands of 1633 cm −1 and 1535 cm −1 are due to the stretching vibration of C=O and the bending vibration of N−H, respectively . In addition, absorption bands of 2969 cm −1 (tensile vibration of C−H on aromatic rings), 2927 cm −1 (tensile vibration of aliphatic C−H), and 1452 cm −1 (tensile vibration of C=C on aromatic rings) can also be found .…”

Section: Resultsmentioning

confidence: 85%

A Novel Self‐protection Hydroquinone Electrochemical Sensor Based on Thermo‐sensitive Triblock Polymer PS‐PNIPAm‐PS

Zhao

Chen

et al. 2020

Electroanalysis

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A novel self‐protection sensor was successfully constructed based on an interesting thermo‐sensitive triblock polymer PS‐PNIPAm‐PS. At low temperatures (<24 °C), the analyte was able to undergo the redox process at the modified electrode. However, the polymer shrunk and accumulated at high temperatures (>30 °C), which dramatically increased the electron transfer resistance (Rct) of the modified electrode and consequently blocked the occurrence of the redox reaction to protect the electrode from high temperatures and enhance its stability. Under optimized conditions, the proposed sensor showed a good detection range for hydroquinone (6×10−7 to 2.35×10−3 M) and a low LOD (490 nM). The sensor was also successfully applied for detecting hydroquinone in real samples. The present work may provide a novel method for electrode protection, high‐temperature alarm, high‐temperature protection of batteries and new sensors production.

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“…Stimuli-responsive polymers have previously been utilized for controlled/triggered drug delivery. , Of particular interest to this publication are poly( N -isopropylacrylamide) (pNIPAm)-based microgels that have the ability to encapsulate therapeutics. , Using microgels as drug carriers has many advantages. For example, the aforementioned side effects of systemic injection of DEX, including osteoporosis and nontraumatic osteonecrosis, can potentially be circumvented.…”

Section: Introductionmentioning

confidence: 99%

Controlled Osteogenic Differentiation of Human Mesenchymal Stem Cells Using Dexamethasone-Loaded Light-Responsive Microgels

Zhang

Fang

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

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Human mesenchymal stem cells (hMSCs), which have the ability to differentiate into osteoblasts, show promise for bone tissue engineering and bone defect treatment. While there are a number of approaches currently available to accomplish this, e.g., utilizing biodegradable materials loaded with the synthetic glucocorticoid osteogenic inducer dexamethasone (DEX), there are still many disadvantages with the current technologies. Here, we generated light-responsive microgels that we showed are capable of loading and releasing DEX in a light-triggered fashion, with the released DEX being able to induce hMSC differentiation into osteoblasts. Specifically, light-responsive poly(N-isopropylacrylamide-co-nitrobenzyl methacrylate) (pNIPAm-co-NBMA) microgels were synthesized via free radical precipitation polymerization and their size, morphology, and chemical composition were characterized. We then went on to show that the microgels could be loaded with DEX (via what we think are hydrophobic interactions) and released upon exposure to UV light. We went on to show that the DEX released from the microgels was still capable of inducing osteogenic differentiation of hMSCs using an alamarBlue assay and normalized alkaline phosphatase (ALP) activity assay. We also investigated how hMSC differentiation was impacted by intermittent DEX released from UV-exposed microgels. Finally, we confirmed that the microgels themselves were not cytotoxic to hMSCs. Taken together, the DEX-loaded light-responsive microgels reported here may find a use for niche clinical applications, e.g., bone tissue repair.

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Temperature-reversible switched antineoplastic drug 5-fluorouracil electrochemical sensor based on adaptable thermo-sensitive microgel encapsulated PEDOT

Cited by 44 publications

References 50 publications

Conductive PNIPAM/CMCS/MWCNT/PANI hydrogel with temperature, pressure and pH sensitivity

Conductive PNIPAM/CMCS/MWCNT/PANI hydrogel with temperature, pressure and pH sensitivity

A Novel Self‐protection Hydroquinone Electrochemical Sensor Based on Thermo‐sensitive Triblock Polymer PS‐PNIPAm‐PS

Controlled Osteogenic Differentiation of Human Mesenchymal Stem Cells Using Dexamethasone-Loaded Light-Responsive Microgels

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