2010
DOI: 10.1002/jps.22091
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Templated Open Flocs of Anisotropic Particles for Pulmonary Delivery with Pressurized Metered Dose Inhalers

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Cited by 22 publications
(7 citation statements)
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“…Itraconazole, for example, was studied in the form of nanosuspension in order to use with pMDI. (43) In this study, itraconazole (ITZ) NanoClusters were formulated in the form of dry powder for DPI applications. Micronized itraconazole as received was milled using different conditions and durations.…”
Section: Formulation Of Itraconazole (Itz)mentioning
confidence: 99%
See 1 more Smart Citation
“…Itraconazole, for example, was studied in the form of nanosuspension in order to use with pMDI. (43) In this study, itraconazole (ITZ) NanoClusters were formulated in the form of dry powder for DPI applications. Micronized itraconazole as received was milled using different conditions and durations.…”
Section: Formulation Of Itraconazole (Itz)mentioning
confidence: 99%
“…For example, Yang et al report itraconazole was milled for 10 days under nitrogen gas to get amorphous ITZ, (36) while Tam et al spent 2 weeks milling ITZ in water to get spherical nanoparticles. (43) Here, ITZ suspensions were collected at milling times of 0.5, 1, and 2 hours.…”
Section: Formulation Of Itraconazole (Itz)mentioning
confidence: 99%
“…Nanosuspension technology would be an effective route to improve the stabilization of the chemical labile drugs [64]. Tam et al [67,68] have recently attempted to achieve stable nanosuspensions via a novel design of flocs structure called "open flocs. " Thin film freezing was used to produce BSA nanorods with aspect ratio of approximately 24.…”
Section: Recent Trend Of Nanosuspensionmentioning
confidence: 99%
“…Much research has been done to address this problem. Beyond the use of surfactants to elevate the activation energy of agglomeration by adding electrostatic or steric barriers between particles [161,162], drug nanoparticles are also designed to reduce the interparticle attraction forces and to improve the DPI performance by blending with carrier materials, forming Trojan particles or controlled nanoparticle agglomerates [160,163].…”
Section: Metered-dose Inhalersmentioning
confidence: 99%