Temporal Trend of Conventional Sperm Parameters in a Sicilian Population in the Decade 2011–2020

Cannarella, Rossella; Condorelli, Rosita A.; Gusmano, Carmelo; Barone, Nunziata; Burrello, Nunziatina; Aversa, Antônio; Calogero, Aldo E.; Vignera, Sandro La

doi:10.3390/jcm10050993

Cited by 16 publications

(13 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent decades, a progressive decline in sperm quality and male fertility has been described [8]. At the same time, lifestyle factors including erroneous eating habits and sedentary lifestyles have dramatically increased the prevalence of obesity in Western countries.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of infertility has increased notably in recent decades. A progressive decline in sperm quality has been described [7,8]. Lifestyle and environmental factors, such as smoking [9], obesity [10], endocrine disruptors [11,12], an exposure to heavy metals [13,14], or psychological stress [15] may have a major role in the decreased sperm quality.…”

Section: Male Infertility: a Problem Of Epidemic Dimensionsmentioning

confidence: 99%

See 1 more Smart Citation

Obesity and Male Reproduction: Do Sirtuins Play a Role?

Barbagallo

Vignera

Cannarella

et al. 2022

IJMS

Self Cite

View full text Add to dashboard Cite

Obesity is a major current public health problem of global significance. A progressive sperm quality decline, and a decline in male fertility, have been reported in recent decades. Several studies have reported a strict relationship between obesity and male reproductive dysfunction. Among the many mechanisms by which obesity impairs male gonadal function, sirtuins (SIRTs) have an emerging role. SIRTs are highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases that play a role in gene regulation, metabolism, aging, and cancer. SIRTs regulate the energy balance, the lipid balance, glucose metabolism, and adipogenesis, but current evidence also indicates a role for SIRTs in male reproduction. However, the majority of the studies have been conducted in animal models and very few have been conducted with humans. This review shows that SIRTs play an important role among the molecular mechanisms by which obesity interferes with male fertility. This highlights the need to deepen this relationship. It will be of particular interest to evaluate whether synthetic and/or natural compounds capable of modifying the activity of SIRTs may also be useful for the treatment of obesity and its effects on gonadal function. Although few studies have explored the role of SIRT activators in obesity-induced male infertility, some molecules, such as resveratrol, appear to be effective in modulating SIRT activity, as well as counteracting the negative effects of obesity on male fertility. The search for strategies to improve male reproductive function in overweight/obese patients is a challenge and understanding the role of SIRTs and their activators may open new interesting scenarios in the coming years.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Male Infertility: a Problem Of Epidemic Dimensionsmentioning

confidence: 99%

Obesity and Male Reproduction: Do Sirtuins Play a Role?

Barbagallo

Vignera

Cannarella

et al. 2022

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Despite extensive research on EDC exposure, information about the consequences is still limited and a matter of debate, due to the limited number of human studies. However, animal models have shown the different mechanisms through which EDCs [ 130 , 131 ] could interfere with endocrine systems and how these alterations could be inherited by the next generations.…”

Section: Testesmentioning

confidence: 99%

Impact of Chemical Endocrine Disruptors and Hormone Modulators on the Endocrine System

Guarnotta

Amodei

Frasca

et al. 2022

IJMS

View full text Add to dashboard Cite

There is growing concern regarding the health and safety issues of endocrine-disrupting chemicals (EDCs). Long-term exposure to EDCs has alarming adverse health effects through both hormone-direct and hormone-indirect pathways. Non-chemical agents, including physical agents such as artificial light, radiation, temperature, and stress exposure, are currently poorly investigated, even though they can seriously affect the endocrine system, by modulation of hormonal action. Several mechanisms have been suggested to explain the interference of EDCs with hormonal activity. However, difficulty in quantifying the exposure, low standardization of studies, and the presence of confounding factors do not allow the establishment of a causal relationship between endocrine disorders and exposure to specific toxic agents. In this review, we focus on recent findings on the effects of EDCs and hormone system modulators on the endocrine system, including the thyroid, parathyroid glands, adrenal steroidogenesis, beta-cell function, and male and female reproductive function.

show abstract

“…In a subsequent study from 2021, changes in semen characteristics were assessed in men at an andrology reference centre in Catania (Sicily) during 2011–2020 (ref. 119 ). During this 10-year period, 1,409 semen analysis reports were randomly selected, and data on sperm concentration, total sperm count, percentage sperm motility and percentage of normal spermatozoa were analysed.…”

Section: Temporal Trends In Human Semen Qualitymentioning

confidence: 99%

Spatiotemporal trends in human semen quality

2022

View full text Add to dashboard Cite

Over the past four decades, studies of various designs have reported spatial and temporal trends in human semen quality. Several standardized-methodology studies in homogeneous populations that compare specific cities within a country or a continent provide clear evidence of geographical differences in sperm production, even over short distances within the same country. Human sperm production is widely believed to be declining over time, but evidence from the scientific literature is less clear. Studies based on repeated cross-sectional data from a single centre have shown mixed results. Among the numerous retrospective studies conducted in a single centre, only some included homogeneous groups of men and appropriate methods, and most of them suggest a temporal decrease in human sperm production in the geographical areas considered. Conclusions reporting temporal trends in sperm production that came from existing retrospective multicentre studies based on individual semen data and those using means, medians or estimates of sperm production are questionable, owing to intrinsic limitations in the studies performed. Regardless of study design, studies on the percentage of motile or morphologically normal spermatozoa are still limited by the inherent variability in assessment. Overall, available data do not enable us to conclude that human semen quality is deteriorating worldwide or in the Western world, but that a trend is observed in some specific areas. To understand these trends and contrasts in sperm and semen quality, prospective studies should be encouraged and combined with assessment of the male exposome.

show abstract

Temporal Trend of Conventional Sperm Parameters in a Sicilian Population in the Decade 2011–2020

Cited by 16 publications

References 47 publications

Obesity and Male Reproduction: Do Sirtuins Play a Role?

Obesity and Male Reproduction: Do Sirtuins Play a Role?

Impact of Chemical Endocrine Disruptors and Hormone Modulators on the Endocrine System

Spatiotemporal trends in human semen quality

Contact Info

Product

Resources

About