Tendon-inspired fibers from liquid crystalline collagen as the pre-oriented bioink

Deng, Feng; Dang, Yuan; Tang, Liang; Hu, Tianshuo; Ding, Chaoliang; Hu, Xiaoqing; Wu, Hui; Chen, Lihui; Huang, Liulian; Ni, Yonghao; Zhang, Min

doi:10.1016/j.ijbiomac.2021.06.173

Cited by 12 publications

(7 citation statements)

References 51 publications

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“…The formation of such structures is facilitated by a decrease in water concentration, shear stresses, and magnetic and electric fields [ 294 , 295 , 296 , 297 , 298 , 299 ]. In conclusion to this section, we should note that interest in the use of gelatin as a basis for the construction of nanomaterials is not decreasing, as evidenced by the works published already in the current century, in particular [ 300 , 301 , 302 , 303 , 304 , 305 , 306 , 307 , 308 , 309 , 310 , 311 , 312 , 313 , 314 , 315 , 316 , 317 , 318 , 319 , 320 , 321 , 322 , 323 , 324 , 325 ]. In fairness, it should also be noted that there are certain difficulties associated with the use of gelatin as a basis for creating functional materials due to its relatively low mechanical strength.…”

Section: Gelatin As An Object For Creating Protein Nanomaterialsmentioning

confidence: 95%

Gelatin as It Is: History and Modernity

Михайлов

2023

IJMS

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The data concerning the synthesis and physicochemical characteristics of one of the practically important proteins—gelatin, as well as the possibilities of its practical application, are systematized and discussed. When considering the latter, emphasis is placed on the use of gelatin in those areas of science and technology that are associated with the specifics of the spatial/molecular structure of this high-molecular compound, namely, as a binder for the silver halide photographic process, immobilized matrix systems with a nano-level organization of an immobilized substance, matrices for creating pharmaceutical/dosage forms and protein-based nanosystems. It was concluded that the use of this protein is promising in the future.

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Section: Gelatin As An Object For Creating Protein Nanomaterialsmentioning

confidence: 95%

Gelatin as It Is: History and Modernity

Михайлов

2023

IJMS

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“…The most crucial factor is shearing. [89][90][91] Deng et al 92 have achieved a synergistic effect by combining molecular preorientation and shear orientation; under the action of shearing force and self-assembly, collagen fiber bundles are arranged along the axis (Figure 3A). Hence, using collagen liquid crystals as a pre-oriented bioink in order to obtain longitudinally aligned bionic collagen fibers with a maximum Young's modulus of up to 966.20 ± 24.30 MPa and tensile strength of 100-140 MPa, with a high tensile strength similar to that of natural tendons.…”

Section: Shear Induced Orientationmentioning

confidence: 99%

Collagen materials with oriented structure for biomedical applications

Zeng,

Tang,

Tian

et al. 2023

Journal of Polymer Science

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As one of the most critical natural structural proteins in tissues, collagen provides a degree of stiffness and rigidity to some of the liquid components of living organisms. Highly oriented materials composed of uniformly arranged collagen play a crucial role in determining the mechanical properties, physiological and biochemical functions of the matrix. Collagen materials with oriented structures promote and support cell migration and proliferation to achieve physiological structure and function. This review outlines the multilayered structure of collagen. It summarizes recent strategies and methods for constructing oriented collagen materials, including mechanical forces, external field effects, template assist, and biomedical applications of oriented collagen. Finally, we present potential challenges and prospects for developing oriented collagen materials.

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“…Collagen is one of the extracellular matrix molecules and is widely used as a hydrogel for the preparation of bio-ink. Based on the inspiration from animal tendon, a study has developed a preoriented bio-ink using collagen liquid crystals that possess excellent wet strength and exhibit wound suture capacity with an increased biodegradability potential, thus suggesting that it could be used for a variety of uses in the biomedical industry [69]. In another study, 4% collagen and chondrocyte were used as a bio-ink for the formation of cartilage.…”

Section: Protein/peptide Polymer-based Bio-inkmentioning

confidence: 99%

Three-Dimensional (3D) Printing in Cancer Therapy and Diagnostics: Current Status and Future Perspectives

Safhi

2022

Pharmaceuticals

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Three-dimensional (3D) printing is a technique where the products are printed layer-by-layer via a series of cross-sectional slices with the exact deposition of different cell types and biomaterials based on computer-aided design software. Three-dimensional printing can be divided into several approaches, such as extrusion-based printing, laser-induced forward transfer-based printing systems, and so on. Bio-ink is a crucial tool necessary for the fabrication of the 3D construct of living tissue in order to mimic the native tissue/cells using 3D printing technology. The formation of 3D software helps in the development of novel drug delivery systems with drug screening potential, as well as 3D constructs of tumor models. Additionally, several complex structures of inner tissues like stroma and channels of different sizes are printed through 3D printing techniques. Three-dimensional printing technology could also be used to develop therapy training simulators for educational purposes so that learners can practice complex surgical procedures. The fabrication of implantable medical devices using 3D printing technology with less risk of infections is receiving increased attention recently. A Cancer-on-a-chip is a microfluidic device that recreates tumor physiology and allows for a continuous supply of nutrients or therapeutic compounds. In this review, based on the recent literature, we have discussed various printing methods for 3D printing and types of bio-inks, and provided information on how 3D printing plays a crucial role in cancer management.

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Tendon-inspired fibers from liquid crystalline collagen as the pre-oriented bioink

Cited by 12 publications

References 51 publications

Gelatin as It Is: History and Modernity

Gelatin as It Is: History and Modernity

Collagen materials with oriented structure for biomedical applications

Three-Dimensional (3D) Printing in Cancer Therapy and Diagnostics: Current Status and Future Perspectives

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