Teratological study of etoperidone in the rat and rabbit

Barcellona, P. Scorza; Fanelli, O; Campana, A.

doi:10.1016/0300-483x(77)90026-9

Cited by 15 publications

(8 citation statements)

References 2 publications

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“…They were kept with normal healthy male albino rats allowing one male for two female rats in one cage overnight [12]. The presence of sperms in the vagina next morning was considered as the first day of pregnancy [13]. Pregnancy was confirmed by persistence of diestrum state for 5 days after mating.…”

Section: Animalsmentioning

confidence: 99%

Effect of Tilmicosin on Fetal Developments in Pregnant Female Albino Rats

Abo-Kora¹,

El-Meleh²,

Aboubakr³

2016

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The effect of tilmicosin on fetal development in pregnant female rats was investigated in this study. Forty pregnant female rats were divided into four groups (each of 10 female rats). Rats in the 1st, 2nd and 3rd groups were received tilmicosin at a dose of 20, 100, 200 mg/kg•b•wt/day orally from the 6th to 15th day of gestation respectively, while the 4th group received 0.5 ml distilled water orally for the same period of gestation and was used as control group. All the pregnant female rats were sacrificed on the 20th day of gestation and their fetuses were subjected to morphological, visceral and skeletal examinations. Tilmicosin at a dose 100, 200 mg/kg•b•wt significantly decreased the number of viable fetuses; the number of resorbed fetuses was increased, and induced retardation in growth of viable fetuses; some skeletal and visceral defects in these fetuses were observed and these effects were dose dependant. It could be concluded that tilmicosin caused some abnormalities and fetal defects, so it is recommended to avoid using pregnancy.

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Section: Animalsmentioning

confidence: 99%

Effect of Tilmicosin on Fetal Developments in Pregnant Female Albino Rats

Abo-Kora¹,

El-Meleh²,

Aboubakr³

2016

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“…They were kept with normal healthy male albino rats allowing one male for two female rats in one cage overnight [10]. The presence of sperms in the vagina next morning was considered as the first day of pregnancy [11]. Pregnancy was confirmed by persistence of diestrus state for 5 days after mating.…”

Section: Methodsmentioning

confidence: 99%

Embryotoxic and Teratogenic Effects of Norfloxacin in Pregnant Female Albino Rats

Aboubakr

Elbadawy

Soliman

et al. 2014

Advances in Pharmacological Sciences

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This study was designed to investigate the possible developmental teratogenicity of norfloxacin in rats. Forty pregnant female rats were divided into four equal groups. Group A received norfloxacin in a dose of 500 mg/kg·b·wt/day orally from 6th to 15th day of gestation. Groups B and C received 1000 and 2000 mg/kg·b·wt/day orally for the same period, respectively; Group D behaved as control and received 0.5 mL distilled water orally for the same period. The dams were killed on 20th day of gestation and their fetuses were subjected to morphological, visceral, and skeletal examinations. Norfloxacin significantly decreased the number of viable fetuses, increased the number of resorbed fetuses, and induced retardation in growth of viable fetuses; some visceral and skeletal defects in these fetuses were seen and these effects were dose dependant. Conclusively, norfloxacin caused some fetal defects and abnormalities, so it is advisable to avoid using this drug during pregnancy.

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“…In the morning, vaginal smear was taken to verify day of pregnancy. Presence of spermatozoa in the obtained vaginal smear suspected pregnancy (Barcellona et al, 1977). Pregnancy was confirmed by persistence of diestrous state for 5 days.…”

Section: Animalsmentioning

confidence: 96%

Some teratological effects of difloxacin in rats

Elkomy

Aboubakr

Medhat

2016

Benha Veterinary Medical Journal

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The aim of this experiment was to detect the teratogenic effects of difloxacin in Wister Albino rats. Thirty pregnant rats were divided into 3 groups; group (1) behaved as control and received normal saline. Group (2) was administered difloxacin at a dose of 20 mg/kg b. wt and group (3) was administered difloxacin at a dose of 40 mg/kg b. wt orally once daily from 6 th to 15 th day of pregnancy. The study revealed no teratogenic effect at a dose of 20 mg/kg b. wt, while at a dose of 40 mg/kg b.wt has significant teratogenic effect showed by decrease in size, weight, length, retarded growth in fetuses, fetal resorption of treated groups, the incidences of skeletal & visceral abnormalities were increased in treated group (40 mg/kg b. wt). It could be concluded that. Administration of difloxacin during early stage of pregnancy and at high dose induce some fetal abnormalities.

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Teratological study of etoperidone in the rat and rabbit

Cited by 15 publications

References 2 publications

Effect of Tilmicosin on Fetal Developments in Pregnant Female Albino Rats

Effect of Tilmicosin on Fetal Developments in Pregnant Female Albino Rats

Embryotoxic and Teratogenic Effects of Norfloxacin in Pregnant Female Albino Rats

Some teratological effects of difloxacin in rats

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